Literature DB >> 25180249

¹⁹F magnetic resonance probes for live-cell detection of peroxynitrite using an oxidative decarbonylation reaction.

Kevin J Bruemmer1, Sara Merrikhihaghi, Christina T Lollar, Siti Nur Sarah Morris, Johannes H Bauer, Alexander R Lippert.   

Abstract

We report a newly discovered oxidative decarbonylation reaction of isatins that is selectively mediated by peroxynitrite (ONOO(-)) to provide anthranilic acid derivatives. We have harnessed this rapid and selective transformation to develop two reaction-based probes, 5-fluoroisatin and 6-fluoroisatin, for the low-background readout of ONOO(-) using (19)F magnetic resonance spectroscopy. 5-fluoroisatin was used to non-invasively detect ONOO(-) formation in living lung epithelial cells stimulated with interferon-γ (IFN-γ).

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Year:  2014        PMID： 25180249     DOI： 10.1039/c4cc04292a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  A Chemiluminescent Probe for HNO Quantification and Real-Time Monitoring in Living Cells.

Authors:  Weiwei An; Lucas S Ryan; Audrey G Reeves; Kevin J Bruemmer; Lyn Mouhaffel; Jeni L Gerberich; Alexander Winters; Ralph P Mason; Alexander R Lippert
Journal:  Angew Chem Int Ed Engl       Date:  2018-12-21       Impact factor: 15.336

2.  A chemiluminescent platform for smartphone monitoring of H2O2 in human exhaled breath condensates.

Authors:  Miguel E Quimbar; Katherine M Krenek; Alexander R Lippert
Journal:  Methods       Date:  2016-05-24       Impact factor: 3.608

Review 3.  Activity-Based Sensing: A Synthetic Methods Approach for Selective Molecular Imaging and Beyond.

Authors:  Kevin J Bruemmer; Steven W M Crossley; Christopher J Chang
Journal:  Angew Chem Int Ed Engl       Date:  2020-04-23       Impact factor: 15.336

Review 4.  Challenges and Opportunities for Small-Molecule Fluorescent Probes in Redox Biology Applications.

Authors:  Xiqian Jiang; Lingfei Wang; Shaina L Carroll; Jianwei Chen; Meng C Wang; Jin Wang
Journal:  Antioxid Redox Signal       Date:  2018-02-16       Impact factor: 8.401

Review 5.  Small-molecule luminescent probes for the detection of cellular oxidizing and nitrating species.

Authors:  Jacek Zielonka; Balaraman Kalyanaraman
Journal:  Free Radic Biol Med       Date:  2018-03-19       Impact factor: 7.376

Review 6.  Chemiluminescence Measurement of Reactive Sulfur and Nitrogen Species.

Authors:  Bo Li; Yujin Lisa Kim; Alexander Ryan Lippert
Journal:  Antioxid Redox Signal       Date:  2021-10-22       Impact factor: 7.468

7.  Design, synthesis and evaluation of novel 19F magnetic resonance sensitive protein tyrosine phosphatase inhibitors.

Authors:  Yu Li; Guiquan Xia; Qi Guo; Li Wu; Shizhen Chen; Zhigang Yang; Wei Wang; Zhong-Yin Zhang; Xin Zhou; Zhong-Xing Jiang
Journal:  Medchemcomm       Date:  2016-06-20       Impact factor: 3.597

8.  Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.

Authors:  Qiuyan Shi; Yu Li; Shaowei Bo; Xiaofei Li; Peng Zhao; Qi Liu; Zhigang Yang; Hengjiang Cong; Hexiang Deng; Mingnan Chen; Shizhen Chen; Xin Zhou; Hong Ding; Zhong-Xing Jiang
Journal:  Chem Commun (Camb)       Date:  2016-03-21       Impact factor: 6.222

9.  A chemiluminescent probe for cellular peroxynitrite using a self-immolative oxidative decarbonylation reaction.

Authors:  Jian Cao; Weiwei An; Audrey G Reeves; Alexander R Lippert
Journal:  Chem Sci       Date:  2018-01-31       Impact factor: 9.825

10.  Seeking Illumination: The Path to Chemiluminescent 1,2-Dioxetanes for Quantitative Measurements and In Vivo Imaging.

Authors:  Uroob Haris; Husain N Kagalwala; Yujin Lisa Kim; Alexander R Lippert
Journal:  Acc Chem Res       Date:  2021-06-10       Impact factor: 24.466
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