Literature DB >> 25151275

A rapid access to novel and diverse 3-oxothiazolo[3,2-c]pyrimidine-8-carboxylates using multicomponent Mannich cyclisation reactions.

Muhammet Yıldırım1, Derya Çelikel.   

Abstract

An efficient synthesis of novel 3-oxotetrahyrothiazolo[3,2-c]pyrimidine-8-carboxylate derivatives was developed by reacting 4-oxothiazolidines with formaldehyde and amines under very mild conditions. A variety of novel thiazolopyrimidine carboxylates were attained rapidly by double Mannich/intramolecular cyclisation reactions in very good yields.

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Year:  2014        PMID： 25151275     DOI： 10.1007/s11030-014-9546-2

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  18 in total

1.  Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives.

Authors:  B Tozkoparan; M Ertan; P Kelicen; R Demirdamar
Journal:  Farmaco       Date:  1999-09-30

2.  Subchronic effects of the GABA-agonist lorazepam and the 5-HT2A/2C antagonist ritanserin on driving performance, slow wave sleep and daytime sleepiness in healthy volunteers.

Authors:  M van Laar; E Volkerts; M Verbaten
Journal:  Psychopharmacology (Berl)       Date:  2001-03-01       Impact factor: 4.530

3.  Substituted thiazoles V. synthesis and antitumor activity of novel thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine analogues.

Authors:  Fatmah A M Al-Omary; Ghada S Hassan; Shahenda M El-Messery; Hussein I El-Subbagh
Journal:  Eur J Med Chem       Date:  2011-10-20       Impact factor: 6.514

4.  Synthesis and anti-HIV-1 activity of novel 2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-ones.

Authors:  K Danel; E B Pedersen; C Nielsen
Journal:  J Med Chem       Date:  1998-01-15       Impact factor: 7.446

5.  SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction.

Authors:  Fraser Hunt; Caroline Austin; Rupert Austin; Roger Bonnert; Peter Cage; Jadeen Christie; Mark Christie; Clare Dixon; Steven Hill; Robert Jewell; Ian Martin; David Robinson; Paul Willis
Journal:  Bioorg Med Chem Lett       Date:  2007-03-03       Impact factor: 2.823

6.  Synthesis and structure-activity relationship study of 2-(substituted benzylidene)-7-(4-fluorophenyl)-5-(furan-2-yl)-2H-thiazolo[3,2-a]pyrimidin-3(7H)-one derivatives as anticancer agents.

Authors:  T P Selvam; V Karthick; P V Kumar; M A Ali
Journal:  Drug Discov Ther       Date:  2012-08

7.  7-trans-(2-Pyridylethenyl)-5H-thiazolo[3,2-a]pyrimidine-5-ones: synthesis and pharmacological activity.

Authors:  G Doria; C Passarotti; R Sala; R Magrini; P Sberze; M Tibolla; R Ceserani; G Arcari; R Castello; D Toti
Journal:  Farmaco Sci       Date:  1985-12

8.  Synthesis, antiproliferative and apoptosis-inducing activity of thiazolo[5,4-d]pyrimidines.

Authors:  Baljinder Singh; Santosh K Guru; Smit Kour; Shreyans K Jain; Rajni Sharma; Parduman R Sharma; Shashank K Singh; Shashi Bhushan; Sandip B Bharate; Ram A Vishwakarma
Journal:  Eur J Med Chem       Date:  2013-10-22       Impact factor: 6.514

9.  Microwave assisted synthesis of some new thiazolopyrimidine, thiazolodipyrimidine and thiazolopyrimidothiazolopyrimidine derivatives with potential antioxidant and antimicrobial activity.

Authors:  Mohamed M Youssef; Mahmoud A Amin
Journal:  Molecules       Date:  2012-08-13       Impact factor: 4.411

Review 10.  Design and synthesis of some substituted thiazolo[3,2-a]pyrimidine derivatives of potential biological activities.

Authors:  Samia G Abdel Moty; Mostafa A Hussein; Salah A Abdel Aziz; Mahrous A Abou-Salim
Journal:  Saudi Pharm J       Date:  2013-12-28       Impact factor: 4.330
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