Literature DB >> 10555260

Synthesis and anti-inflammatory activities of some thiazolo[3,2-a]pyrimidine derivatives.

B Tozkoparan1, M Ertan, P Kelicen, R Demirdamar.   

Abstract

Sixteen new 2-benzylidene-7-methyl-3-oxo-5-(substituted phenyl)-2, 3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid methyl esters (1a-4d) have been synthesized by reacting 1,2,3,4-tetrahydropyrimidine-2-thiones (1-4) with chloroacetic acid and appropriate benzaldehydes in a single step. Their structures have been proved by IR, 1H NMR, mass spectra and elemental analysis. The compounds were tested for their anti-inflammatory activities. Test results revealed that compounds 1b, 1c, 4a and 4c exerted moderate anti-inflammatory activity at the 100 mg/kg dose level compared with indomethacin.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10555260     DOI： 10.1016/s0014-827x(99)00068-3

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  18 in total

1.  A rapid access to novel and diverse 3-oxothiazolo[3,2-c]pyrimidine-8-carboxylates using multicomponent Mannich cyclisation reactions.

Authors:  Muhammet Yıldırım; Derya Çelikel
Journal:  Mol Divers       Date:  2014-08-24       Impact factor: 2.943

2.  Fluorescence Properties and Electrochemical Behavior of Some Schiff Bases Derived from N-Aminopyrimidine.

Authors:  Mehmet Gulcan; Ümit Doğru; Gülsiye Öztürk; Abdulkadir Levent; Esvet Akbaş
Journal:  J Fluoresc       Date:  2013-09-21       Impact factor: 2.217

3.  One-pot synthesis, biological evaluation and molecular docking studies of fused thiazolo[2,3-b]pyrimidinone-pyrazolylcoumarin hybrids.

Authors:  Ramesh Gondru; Saikiran Reddy Peddi; Vijjulatha Manga; Manjulatha Khanapur; Rajitha Gali; Narsimha Sirassu; Rajitha Bavantula
Journal:  Mol Divers       Date:  2018-07-02       Impact factor: 2.943

4.  Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives.

Authors:  Marjan Esfahanizadeh; Shohreh Mohebbi; Behnam Dasht Bozorg; Salimeh Amidi; Ali Gudarzi; Seyed Abdolmajid Ayatollahi; Farzad Kobarfard
Journal:  Iran J Pharm Res       Date:  2015       Impact factor: 1.696

5.  Synthesis of some novel chromenopyrimidine derivatives and evaluation of their biological activities.

Authors:  Akbar Mobinikhaledi; Naser Foroughifar; Tahere Mosleh; Ahmad Hamta
Journal:  Iran J Pharm Res       Date:  2014       Impact factor: 1.696

6.  Design, synthesis and antimicrobial evaluation of pyrimidin-2-ol/thiol/amine analogues.

Authors:  Sangeeta Narwal; Sanjiv Kumar; Prabhakar Kumar Verma
Journal:  Chem Cent J       Date:  2017-06-09       Impact factor: 4.215

7.  Biomimetic hydrogenation of electron deficient olefins using in situ generated 2-arylbenzimidazoline: synthesis of novel 3-benzylbenzo[4,5]thiazolo[3,2-a]pyrimidin-4-ones.

Authors:  Maryam Danehchin; Abbas Ali Esmaeili
Journal:  Mol Divers       Date:  2021-06-11       Impact factor: 2.943

8.  Synthesis of functionalized imidazo[4,5-e]thiazolo[3,2-b]triazines by condensation of imidazo[4,5-e]triazinethiones with DMAD or DEAD and rearrangement to imidazo[4,5-e]thiazolo[2,3-c]triazines.

Authors:  Alexei N Izmest'ev; Dmitry B Vinogradov; Natalya G Kolotyrkina; Angelina N Kravchenko; Galina A Gazieva
Journal:  Beilstein J Org Chem       Date:  2021-05-14       Impact factor: 2.883

9.  Herbicidal properties of antihypertensive drugs: calcium channel blockers.

Authors:  Hannan Safiyyah Tan Sian Hui Abdullah; Poh Wai Chia; Dzolkhifli Omar; Tse Seng Chuah
Journal:  Sci Rep       Date:  2021-07-09       Impact factor: 4.379

Review 10.  Design and synthesis of some substituted thiazolo[3,2-a]pyrimidine derivatives of potential biological activities.

Authors:  Samia G Abdel Moty; Mostafa A Hussein; Salah A Abdel Aziz; Mahrous A Abou-Salim
Journal:  Saudi Pharm J       Date:  2013-12-28       Impact factor: 4.330
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.