| Literature DB >> 25137478 |
Christopher M Brackett1, Roberta J Melander, Il Hwan An, Aparna Krishnamurthy, Richele J Thompson, John Cavanagh, Christian Melander.
Abstract
Recent efforts toward combating antibiotic resistance in bacteria have focused on Gram-positive bacteria; however, multidrug-resistant Gram-negative bacteria pose a significant risk to public health. An orthogonal approach to the development of new antibiotics is to develop adjuvant compounds that enhance the susceptibility of drug-resistant strains of bacteria to currently approved antibiotics. This paper describes the synthesis and biological activity of a library of aryl amide 2-aminoimidazoles based on a lead structure from an initial screen. A small molecule was identified from this library that is capable of lowering the minimum inhibitory concentration of β-lactam antibiotics by up to 64-fold.Entities:
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Year: 2014 PMID： 25137478 DOI： 10.1021/jm501050e
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446