Thuy Lam1, Paige L Williams2, Mary M Lee3, Susan A Korrick4, Linda S Birnbaum5, Jane S Burns6, Oleg Sergeyev7, Boris Revich8, Larisa M Altshul9, Donald G Patterson10, Wayman E Turner11, Russ Hauser12. 1. Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Quintiles, Cambridge, MA, USA. 2. Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. 3. Pediatric Endocrine Division, Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA; Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA, USA. 4. Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 5. National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA. 6. Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. 7. Samara State Medical University, Department of Physical Education and Health, Samara, Russia; Chapaevsk Medical Association, Chapaevsk, Samara Region, Russia. 8. Institute for Forecasting, Russian Academy of Sciences, Moscow, Russia. 9. Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA; Environmental Health and Engineering, Inc., Needham, MA, USA. 10. EnviroSolutions Consulting, Inc., Auburn, GA, USA; Axys Analytical Solutions, Sidney, BC, Canada; Exponent, Inc., Maynard, MA, USA. 11. Centers for Disease Control and Prevention, Atlanta, GA, USA. 12. Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA. Electronic address: rhauser@hsph.harvard.edu.
Abstract
BACKGROUND: In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development; however, epidemiological data are limited and inconsistent. OBJECTIVE: To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE)] with male pubertal onset. METHODS: In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8-9 year old boys with measured OCPs were enrolled during 2003-2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV)>3 mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset. RESULTS: In adjusted models, boys with higher HCB concentrations had later mean ages of TV>3 mL and P2+ (but not G2+). Mean age at attaining TV>3 mL was delayed 3.6 (95% CI: -2.6, 9.7), 7.9 (95% CI: 1.7, 14.0), and 4.7 months (95% CI: -1.4, 10.9) for HCB Q2, Q3, and Q4, respectively, compared to Q1 (trend p: 0.06). Boys with higher HCB concentrations reached P2+ 0.1 months earlier (95% CI: -5.8, 5.6) for Q2, 4.7 months later (95% CI: -1.0, 10.3) for Q3 and 4.6 months later (95% CI: -1.1, 10.3) for Q4 compared to Q1 (trend p: 0.04). There were no associations of serum β-HCH and p,p'-DDE concentrations with age of pubertal onset. CONCLUSION: Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche.
BACKGROUND: In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development; however, epidemiological data are limited and inconsistent. OBJECTIVE: To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE)] with male pubertal onset. METHODS: In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8-9 year old boys with measured OCPs were enrolled during 2003-2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV)>3 mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset. RESULTS: In adjusted models, boys with higher HCB concentrations had later mean ages of TV>3 mL and P2+ (but not G2+). Mean age at attaining TV>3 mL was delayed 3.6 (95% CI: -2.6, 9.7), 7.9 (95% CI: 1.7, 14.0), and 4.7 months (95% CI: -1.4, 10.9) for HCB Q2, Q3, and Q4, respectively, compared to Q1 (trend p: 0.06). Boys with higher HCB concentrations reached P2+ 0.1 months earlier (95% CI: -5.8, 5.6) for Q2, 4.7 months later (95% CI: -1.0, 10.3) for Q3 and 4.6 months later (95% CI: -1.1, 10.3) for Q4 compared to Q1 (trend p: 0.04). There were no associations of serum β-HCH and p,p'-DDE concentrations with age of pubertal onset. CONCLUSION: Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche.
Authors: N Georgopoulos; K Markou; A Theodoropoulou; P Paraskevopoulou; L Varaki; Z Kazantzi; M Leglise; A G Vagenakis Journal: J Clin Endocrinol Metab Date: 1999-12 Impact factor: 5.958
Authors: Marcia E Herman-Giddens; Jennifer Steffes; Donna Harris; Eric Slora; Michael Hussey; Steven A Dowshen; Richard Wasserman; Janet R Serwint; Lynn Smitherman; Edward O Reiter Journal: Pediatrics Date: 2012-10-20 Impact factor: 7.124
Authors: Thuy Lam; Paige L Williams; Jane S Burns; Oleg Sergeyev; Susan A Korrick; Mary M Lee; Linda S Birnbaum; Boris Revich; Larisa M Altshul; Donald G Patterson; Wayman E Turner; Russ Hauser Journal: Environ Health Perspect Date: 2013-08-16 Impact factor: 9.031
Authors: Oleg Sergeyev; Jane S Burns; Paige L Williams; Susan A Korrick; Mary M Lee; Boris Revich; Russ Hauser Journal: Rev Environ Health Date: 2017-03-01 Impact factor: 3.458
Authors: Jane S Burns; Oleg Sergeyev; Mary M Lee; Paige L Williams; Lidia Mínguez-Alarcón; Bora Plaku-Alakbarova; Sergey Sokolov; Sergey Kovalev; Holger M Koch; Albert T Lebedev; Russ Hauser; Susan A Korrick Journal: Environ Res Date: 2022-04-04 Impact factor: 8.431
Authors: C S Uldbjerg; T Koch; Y-H Lim; L S Gregersen; C S Olesen; A-M Andersson; H Frederiksen; B A Coull; R Hauser; A Juul; E V Bräuner Journal: Hum Reprod Update Date: 2022-08-25 Impact factor: 17.179
Authors: Gayle C Windham; Susan M Pinney; Robert W Voss; Andreas Sjödin; Frank M Biro; Louise C Greenspan; Susan Stewart; Robert A Hiatt; Lawrence H Kushi Journal: Environ Health Perspect Date: 2015-05-08 Impact factor: 9.031
Authors: Thuy Lam; Paige L Williams; Mary M Lee; Susan A Korrick; Linda S Birnbaum; Jane S Burns; Oleg Sergeyev; Boris Revich; Larisa M Altshul; Donald G Patterson; Russ Hauser Journal: Environ Health Perspect Date: 2015-05-22 Impact factor: 9.031