| Literature DB >> 25103681 |
Linda Zane1, Vivek Sharma1, Tom Misteli2.
Abstract
Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly--or possibly coincidentally--several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis. Published by Elsevier Ltd.Entities:
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Year: 2014 PMID: 25103681 PMCID: PMC4254271 DOI: 10.1016/j.tcb.2014.07.001
Source DB: PubMed Journal: Trends Cell Biol ISSN: 0962-8924 Impact factor: 20.808