Literature DB >> 25103681

Common features of chromatin in aging and cancer: cause or coincidence?

Linda Zane1, Vivek Sharma1, Tom Misteli2.   

Abstract

Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly--or possibly coincidentally--several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis. Published by Elsevier Ltd.

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Year:  2014        PMID: 25103681      PMCID: PMC4254271          DOI: 10.1016/j.tcb.2014.07.001

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN: 0962-8924            Impact factor:   20.808


  141 in total

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