| Literature DB >> 17055429 |
William Y Kim1, Norman E Sharpless.
Abstract
Loss of the INK4a/ARF/INK4b locus on chromosome 9p21 is among the most frequent cytogenetic events in human cancer. The products of the locus--p15(INK4b), p16(INK4a), and ARF--play widespread and independent roles in tumor suppression. Recent data also suggest that expression of p16(INK4a) induces an age-dependent decrease in the proliferative capacity of certain tissue-specific stem cells and unipotent progenitors. Here, we discuss the regulation and role of p16(INK4a), ARF, and p15(INK4b) in cancer and aging.Entities:
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Year: 2006 PMID： 17055429 DOI： 10.1016/j.cell.2006.10.003
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582