Sérgio Monteiro de Almeida1, Jennifer Marquie-Beck1, Archana Bhatt2, Scott Letendre3, Allen McCutchan3, Ron Ellis1. 1. Departments of Neurosciences, HIV Neurobehavioral Research Center, University of California, San Diego, USA. 2. Departments of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, USA. 3. School of Medicine, HIV Neurobehavioral Research Center, University of California, San Diego, USA.
Abstract
UNLABELLED: Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals. OBJECTIVE: To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. METHOD: CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend portable analyzer were compared to those tested by a reference device (SYNCHRON LX 20). RESULTS: The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%. CONCLUSIONS: These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a "false positive test", and should be confirmed by the reference device before concluding abnormality.
UNLABELLED: Increased plasma lactate levels can indicate the presence of metabolic disorders in HIV infected individuals. OBJECTIVE: To determine whether a portable analyzer is valid for measuring cerebrospinal fluid (CSF) and plasma lactate levels in HIV infected individuals. METHOD: CSF and plasma were collected from 178 subjects. Samples tested by the Accutrend portable analyzer were compared to those tested by a reference device (SYNCHRON LX 20). RESULTS: The portable analyzer had in plasma sensitivity of 0.95 and specificity 0.87. For CSF the specificity was 0.95; the sensitivity 0.33; the negative predictive value was 95% and the positive predictive value 33%. CONCLUSIONS: These findings support the validity of the portable analyzer in measuring lactate concentrations in CSF that fall within the normal range. The relatively poor positive predictive value indicates that a result above the reference range may represent a "false positive test", and should be confirmed by the reference device before concluding abnormality.
Authors: Elmarie Terblanche; Werner A Cloete; Pieter A L du Plessis; Jacques N Sadie; Annemie Strauss; Marianne Unger Journal: Eur J Appl Physiol Date: 2003-07-26 Impact factor: 3.078
Authors: Christopher C Moore; Shevin T Jacob; Relana Pinkerton; David B Meya; Harriet Mayanja-Kizza; Steven J Reynolds; W Michael Scheld Journal: Clin Infect Dis Date: 2008-01-15 Impact factor: 9.079