Literature DB >> 25027381

A high throughput flow cytometric assay platform targeting transporter inhibition.

George P Tegos1, Annette M Evangelisti2, J Jacob Strouse2, Oleg Ursu3, Cristian Bologa3, Larry A Sklar4.   

Abstract

This review highlights the concepts, recent applications and limitations of High Throughput Screening (HTS) flow cytometry-based efflux inhibitory assays. This platform has been employed in mammalian and yeast efflux systems leading to the identification of small molecules with transporter inhibitory capabilities. This technology offers the possibility of substrate multiplexing and may promote novel strategies targeting microbial efflux systems. This platform can generate a comprehensive dataset that may support efforts to map the interface between chemistry and transporter biology in a variety of pathogenic systems.

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Year:  2014        PMID： 25027381      PMCID： PMC4101541          DOI： 10.1016/j.ddtec.2014.03.010

Source DB:  PubMed          Journal:  Drug Discov Today Technol        ISSN： 1740-6749


  47 in total

Review 1.  The controversial role of ABC transporters in clinical oncology.

Authors:  Akina Tamaki; Caterina Ierano; Gergely Szakacs; Robert W Robey; Susan E Bates
Journal:  Essays Biochem       Date:  2011-09-07       Impact factor: 8.000

Review 2.  Membrane transporters in drug development.

Authors:  Kathleen M Giacomini; Shiew-Mei Huang; Donald J Tweedie; Leslie Z Benet; Kim L R Brouwer; Xiaoyan Chu; Amber Dahlin; Raymond Evers; Volker Fischer; Kathleen M Hillgren; Keith A Hoffmaster; Toshihisa Ishikawa; Dietrich Keppler; Richard B Kim; Caroline A Lee; Mikko Niemi; Joseph W Polli; Yuichi Sugiyama; Peter W Swaan; Joseph A Ware; Stephen H Wright; Sook Wah Yee; Maciej J Zamek-Gliszczynski; Lei Zhang
Journal:  Nat Rev Drug Discov       Date:  2010-03       Impact factor: 84.694

3.  Computational models for identifying potential P-glycoprotein substrates and inhibitors.

Authors:  Patrizia Crivori; Benedetta Reinach; Daniele Pezzetta; Italo Poggesi
Journal:  Mol Pharm       Date:  2006 Jan-Feb       Impact factor: 4.939

4.  Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells.

Authors:  Yan Li; Jezrael L Revalde; Glen Reid; James W Paxton
Journal:  Cancer Chemother Pharmacol       Date:  2010-11-30       Impact factor: 3.333

5.  Image-based chemical screening identifies drug efflux inhibitors in lung cancer cells.

Authors:  Xiaofeng Xia; Jian Yang; Fuhai Li; Ying Li; Xiaobo Zhou; Yue Dai; Stephen T C Wong
Journal:  Cancer Res       Date:  2010-09-14       Impact factor: 12.701

Review 6.  Three decades of P-gp inhibitors: skimming through several generations and scaffolds.

Authors:  A Palmeira; E Sousa; M H Vasconcelos; M M Pinto
Journal:  Curr Med Chem       Date:  2012       Impact factor: 4.530

7.  Identification of Nile red as a fluorescent substrate of the Candida albicans ATP-binding cassette transporters Cdr1p and Cdr2p and the major facilitator superfamily transporter Mdr1p.

Authors:  Irena Ivnitski-Steele; Ann R Holmes; Erwin Lamping; Brian C Monk; Richard D Cannon; Larry A Sklar
Journal:  Anal Biochem       Date:  2009-07-03       Impact factor: 3.365

Review 8.  Targeting multidrug resistance in cancer.

Authors:  Gergely Szakács; Jill K Paterson; Joseph A Ludwig; Catherine Booth-Genthe; Michael M Gottesman
Journal:  Nat Rev Drug Discov       Date:  2006-03       Impact factor: 84.694

Review 9.  The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).

Authors:  Gergely Szakács; András Váradi; Csilla Ozvegy-Laczka; Balázs Sarkadi
Journal:  Drug Discov Today       Date:  2008-02-20       Impact factor: 7.851

10.  ABC transporters in cancer: more than just drug efflux pumps.

Authors:  Jamie I Fletcher; Michelle Haber; Michelle J Henderson; Murray D Norris
Journal:  Nat Rev Cancer       Date:  2010-01-15       Impact factor: 60.716
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  8 in total

Review 1.  Transport in technicolor: mapping ATP-binding cassette transporters in sea urchin embryos.

Authors:  Tufan Gökirmak; Lauren E Shipp; Joseph P Campanale; Sascha C T Nicklisch; Amro Hamdoun
Journal:  Mol Reprod Dev       Date:  2014-08-22       Impact factor: 2.609

Review 2.  Targeting efflux pumps to overcome antifungal drug resistance.

Authors:  Ann R Holmes; Tony S Cardno; J Jacob Strouse; Irena Ivnitski-Steele; Mikhail V Keniya; Kurt Lackovic; Brian C Monk; Larry A Sklar; Richard D Cannon
Journal:  Future Med Chem       Date:  2016-07-27       Impact factor: 3.808

3.  Defining the microbial effluxome in the content of the host-microbiome interaction.

Authors:  Anastasios Ioannidis; Maria Magana; Cristian G Bologa; Tudor I Oprea; Ian T Paulsen; George P Tegos
Journal:  Front Pharmacol       Date:  2015-02-19       Impact factor: 5.810

4.  Exploiting Single-Cell Quantitative Data to Map Genetic Variants Having Probabilistic Effects.

Authors:  Florent Chuffart; Magali Richard; Daniel Jost; Claire Burny; Hélène Duplus-Bottin; Yoshikazu Ohya; Gaël Yvert
Journal:  PLoS Genet       Date:  2016-08-01       Impact factor: 5.917

5.  Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli.

Authors:  Srijan Jindal; Lei Yang; Philip J Day; Douglas B Kell
Journal:  BMC Microbiol       Date:  2019-08-22       Impact factor: 3.605

6.  Structural Similarities between Some Common Fluorophores Used in Biology, Marketed Drugs, Endogenous Metabolites, and Natural Products.

Authors:  Steve O'Hagan; Douglas B Kell
Journal:  Mar Drugs       Date:  2020-11-23       Impact factor: 5.118

7.  An optogenetic assay method for electrogenic transporters using Escherichia coli co-expressing light-driven proton pump.

Authors:  Masahiro Hayashi; Keiichi Kojima; Yuki Sudo; Atsuko Yamashita
Journal:  Protein Sci       Date:  2021-07-10       Impact factor: 6.993

Review 8.  The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes.

Authors:  Douglas B Kell
Journal:  Molecules       Date:  2021-09-16       Impact factor: 4.411
  8 in total

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