Literature DB >> 20075923

ABC transporters in cancer: more than just drug efflux pumps.

Jamie I Fletcher1, Michelle Haber, Michelle J Henderson, Murray D Norris.   

Abstract

Multidrug transporter proteins are best known for their contributions to chemoresistance through the efflux of anticancer drugs from cancer cells. However, a considerable body of evidence also points to their importance in cancer extending beyond drug transport to fundamental roles in tumour biology. Currently, much of the evidence for these additional roles is correlative and definitive studies are needed to confirm causality. We propose that delineating the precise roles of these transporters in tumorigenesis and treatment response will be important for the development of more effective targeted therapies.

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Year:  2010        PMID： 20075923     DOI： 10.1038/nrc2789

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  185 in total

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