Literature DB >> 24990812

Detecting enzyme activities with exogenous MRI contrast agents.

Dina V Hingorani1, Byunghee Yoo, Adam S Bernstein, Mark D Pagel.   

Abstract

This review focuses on exogenous magnetic resonance imaging (MRI) contrast agents that are responsive to enzyme activity. Enzymes can catalyze a change in water access, rotational tumbling time, the proximity of a (19)F-labeled ligand, the aggregation state, the proton chemical-exchange rate between the agent and water, or the chemical shift of (19)F, (31)P, (13)C or a labile (1)H of an agent, all of which can be used to detect enzyme activity. The variety of agents attests to the creativity in developing enzyme-responsive MRI contrast agents.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  CEST MRI; MR spectroscopy; enzymes; imaging agents; relaxation-based MRI

Mesh：

Substances：

Year:  2014        PMID： 24990812      PMCID： PMC4117811          DOI： 10.1002/chem.201402474

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  91 in total

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Journal:  Hum Gene Ther       Date:  2005-12       Impact factor: 5.695

Review 2.  19F: a versatile reporter for non-invasive physiology and pharmacology using magnetic resonance.

Authors:  Jian-xin Yu; Vikram D Kodibagkar; Weina Cui; Ralph P Mason
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3.  Use of ultrasound imaging and fluoroscopic imaging to study gastric retention of enzyme-digestible hydrogels.

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4.  13C NMR studies of gluconeogenesis in rat liver cells: utilization of labeled glycerol by cells from euthyroid and hyperthyroid rats.

Authors:  S M Cohen; S Ogawa; R G Shulman
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6.  Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate.

Authors:  Magnus Karlsson; Pernille R Jensen; René in 't Zandt; Anna Gisselsson; Georg Hansson; Jens Ø Duus; Sebastian Meier; Mathilde H Lerche
Journal:  Int J Cancer       Date:  2010-08-01       Impact factor: 7.396

7.  Formaldehyde metabolism by Escherichia coli. Detection by in vivo 13C NMR spectroscopy of S-(hydroxymethyl)glutathione as a transient intracellular intermediate.

Authors:  R P Mason; J K Sanders; A Crawford; B K Hunter
Journal:  Biochemistry       Date:  1986-08-12       Impact factor: 3.162

8.  New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging.

Authors:  Beata Jastrzebska; Réjean Lebel; Hélène Therriault; J Oliver McIntyre; Emanuel Escher; Brigitte Guérin; Benoit Paquette; Witold A Neugebauer; Martin Lepage
Journal:  J Med Chem       Date:  2009-03-26       Impact factor: 7.446

9.  Respiratory control and substrate effects in the working rat heart.

Authors:  F M Jeffrey; C R Malloy
Journal:  Biochem J       Date:  1992-10-01       Impact factor: 3.857

10.  Bioluminescence imaging of myeloperoxidase activity in vivo.

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  8 in total

Review 1.  Methods of Measuring Enzyme Activity Ex Vivo and In Vivo.

Authors:  Yangguang Ou; Rachael E Wilson; Stephen G Weber
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2018-03-05       Impact factor: 10.745

2.  A cationic gadolinium contrast agent for magnetic resonance imaging of cartilage.

Authors:  Jonathan D Freedman; Hrvoje Lusic; Martin Wiewiorski; Michelle Farley; Brian D Snyder; Mark W Grinstaff
Journal:  Chem Commun (Camb)       Date:  2015-06-30       Impact factor: 6.222

Review 3.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

4.  Imaging of Enzyme Activity by Electron Paramagnetic Resonance: Concept and Experiment Using a Paramagnetic Substrate of Alkaline Phosphatase.

Authors:  Urikhan Sanzhaeva; Xuan Xu; Priyaankadevi Guggilapu; Mark Tseytlin; Valery V Khramtsov; Benoit Driesschaert
Journal:  Angew Chem Int Ed Engl       Date:  2018-08-07       Impact factor: 15.336

Review 5.  Advances in Magnetic Resonance Imaging Contrast Agents for Biomarker Detection.

Authors:  Sanhita Sinharay; Mark D Pagel
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2016-03-30       Impact factor: 10.745

6.  An enzyme-activatable and cell-permeable MnIII-porphyrin as a highly efficient T1 MRI contrast agent for cell labeling.

Authors:  Inga E Haedicke; Tan Li; Yong Le K Zhu; Francisco Martinez; Amanda M Hamilton; Donna H Murrell; Joris T Nofiele; Hai-Ling M Cheng; Timothy J Scholl; Paula J Foster; Xiao-An Zhang
Journal:  Chem Sci       Date:  2016-03-16       Impact factor: 9.825

7.  Accelerated 19F·MRI Detection of Matrix Metalloproteinase-2/-9 through Responsive Deactivation of Paramagnetic Relaxation Enhancement.

Authors:  Henryk M Faas; James L Krupa; Alexander J Taylor; Francesco Zamberlan; Christopher J Philp; Huw E L Williams; Simon R Johnson; Galina E Pavlovskaya; Neil R Thomas; Thomas Meersmann
Journal:  Contrast Media Mol Imaging       Date:  2019-02-28       Impact factor: 3.161

Review 8.  Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective.

Authors:  Gonçalo S Clemente; Aren van Waarde; Inês F Antunes; Alexander Dömling; Philip H Elsinga
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  8 in total

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