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Literature DB >> 24981598

Comparative genetics of longevity and cancer: insights from long-lived rodents.

Vera Gorbunova¹, Andrei Seluanov¹, Zhengdong Zhang², Vadim N Gladyshev³, Jan Vijg².

Abstract

Mammals have evolved a remarkable diversity of ageing rates. Within the single order of Rodentia, maximum lifespans range from 4 years in mice to 32 years in naked mole rats. Cancer rates also differ substantially between cancer-prone mice and almost cancer-proof naked mole rats and blind mole rats. Recent progress in rodent comparative biology, together with the emergence of whole-genome sequence information, has opened opportunities for the discovery of genetic factors that control longevity and cancer susceptibility.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2014 PMID： 24981598 PMCID： PMC4353926 DOI： 10.1038/nrg3728

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

74 in total

Review 1. Hyaluronan: from extracellular glue to pericellular cue.

Authors: Bryan P Toole
Journal: Nat Rev Cancer Date: 2004-07 Impact factor: 60.716

2. Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse.

Authors: Ludovic Orlando; Aurélien Ginolhac; Guojie Zhang; Duane Froese; Anders Albrechtsen; Mathias Stiller; Mikkel Schubert; Enrico Cappellini; Bent Petersen; Ida Moltke; Philip L F Johnson; Matteo Fumagalli; Julia T Vilstrup; Maanasa Raghavan; Thorfinn Korneliussen; Anna-Sapfo Malaspinas; Josef Vogt; Damian Szklarczyk; Christian D Kelstrup; Jakob Vinther; Andrei Dolocan; Jesper Stenderup; Amhed M V Velazquez; James Cahill; Morten Rasmussen; Xiaoli Wang; Jiumeng Min; Grant D Zazula; Andaine Seguin-Orlando; Cecilie Mortensen; Kim Magnussen; John F Thompson; Jacobo Weinstock; Kristian Gregersen; Knut H Røed; Véra Eisenmann; Carl J Rubin; Donald C Miller; Douglas F Antczak; Mads F Bertelsen; Søren Brunak; Khaled A S Al-Rasheid; Oliver Ryder; Leif Andersson; John Mundy; Anders Krogh; M Thomas P Gilbert; Kurt Kjær; Thomas Sicheritz-Ponten; Lars Juhl Jensen; Jesper V Olsen; Michael Hofreiter; Rasmus Nielsen; Beth Shapiro; Jun Wang; Eske Willerslev
Journal: Nature Date: 2013-06-26 Impact factor: 49.962

Review 3. Genetics of increased lifespan in Drosophila.

Authors: M R Rose
Journal: Bioessays Date: 1989-11 Impact factor: 4.345

Review 4. Cellular senescence as a tumor-suppressor mechanism.

Authors: J Campisi
Journal: Trends Cell Biol Date: 2001-11 Impact factor: 20.808

5. Mortality in north american dogs from 1984 to 2004: an investigation into age-, size-, and breed-related causes of death.

Authors: J M Fleming; K E Creevy; D E L Promislow
Journal: J Vet Intern Med Date: 2011-02-25 Impact factor: 3.333

Comparative genetics of longevity and cancer: insights from long-lived rodents.

Review 1. Hyaluronan: from extracellular glue to pericellular cue.

2. Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse.

Review 3. Genetics of increased lifespan in Drosophila.

Review 4. Cellular senescence as a tumor-suppressor mechanism.

5. Mortality in north american dogs from 1984 to 2004: an investigation into age-, size-, and breed-related causes of death.

Review 6. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

7. The molecular basis of acid insensitivity in the African naked mole-rat.

Review 8. The Human Ageing Genomic Resources: online databases and tools for biogerontologists.

9. Rodents for comparative aging studies: from mice to beavers.

10. Genetic loci that influence cause of death in a heterogeneous mouse stock.

1. When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow?

2. The big, the bad and the ugly: Extreme animals as inspiration for biomedical research.

3. Ecology, longevity and naked mole-rats: confounding effects of sociality?

4. Cancer resistance, high molecular weight hyaluronic acid, and longevity.

Review 5. Molecular signatures of longevity: Insights from cross-species comparative studies.

Review 6. DNA double strand break repair, aging and the chromatin connection.

Review 7. The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span.

8. A platform for rapid exploration of aging and diseases in a naturally short-lived vertebrate.

9. DNA helix: the importance of being AT-rich.

10. Size matters: height, cell number and a person's risk of cancer.