Literature DB >> 2493319

Identification of tumor promoters by their inhibitory effect on intercellular transfer of lucifer yellow.

I V Budunova1, L A Mittelman, G A Belitsky.   

Abstract

The effect of the tumor promoters 12-O-tetradecanoylphorbol-13-acetate (TPA), mezerein, teleocidin, anthralin, the Ca2+-ionophore A23187, butylated hydroxytoluene (BHT), dichlorodiphenyltrichloroethane (DDT) and phenobarbital (PB) on lucifer yellow transfer in cultures of SV-40-transformed Djungarian hamster fibroblasts was studied. TPA, mezerein, teleocidin, A23187, DDT and BHT exerted a strong inhibitory effect on cell-to-cell dye transfer. Anthralin uncoupled cells in 3 experiments out of 6. PB appeared to enhance lucifer yellow transfer. Sodium nitrite, a substance with unknown promoting activity, effectively uncoupled cells. All the promoters investigated had a reversible effect on the dye transfer. The value of the dye transfer method for promoter screening is discussed.

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Year:  1989        PMID： 2493319     DOI： 10.1007/bf00141066

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  39 in total

1.  Down regulation of phorbol diester receptors by proteolytic degradation of protein kinase C in a cultured cell line of fetal rat skin keratinocytes.

Authors:  K Chida; N Kato; T Kuroki
Journal:  J Biol Chem       Date:  1986-10-05       Impact factor: 5.157

Review 2.  Junctional intercellular communication: the cell-to-cell membrane channel.

Authors:  W R Loewenstein
Journal:  Physiol Rev       Date:  1981-10       Impact factor: 37.312

3.  Classification of genotoxic and epigenetic hepatocarcinogens using liver culture assays.

Authors:  G M Williams
Journal:  Ann N Y Acad Sci       Date:  1980       Impact factor: 5.691

4.  Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.

Authors:  L P Yotti; C C Chang; J E Trosko
Journal:  Science       Date:  1979-11-30       Impact factor: 47.728

5.  Enhancing effect of butylated hydroxytoluene on the development of liver altered foci and neoplasms induced by N-2-fluorenylacetamide in rats.

Authors:  Y Maeura; G M Williams
Journal:  Food Chem Toxicol       Date:  1984-03       Impact factor: 6.023

6.  Bombesin and phorbol ester stimulate phosphatidylcholine hydrolysis by phospholipase C: evidence for a role of protein kinase C.

Authors:  J G Muir; A W Murray
Journal:  J Cell Physiol       Date:  1987-03       Impact factor: 6.384

7.  Promoting effects of phenobarbital and barbital on development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.

Authors:  Y Hiasa; Y Kitahori; M Ohshima; T Fujita; T Yuasa; N Konishi; A Miyashiro
Journal:  Carcinogenesis       Date:  1982       Impact factor: 4.944

8.  Inhibition of intercellular communication in Chinese hamster V79 cells by teleocidin.

Authors:  C M Jone; J E Trosko; C Chang; H Fujiki; T Sugimura
Journal:  Gan       Date:  1982-12

9.  Phorbol ester-mediated inhibition of intercellular communication in BALB/c 3T3 cells: relationship to enhancement of cell transformation.

Authors:  T Enomoto; H Yamasaki
Journal:  Cancer Res       Date:  1985-06       Impact factor: 12.701

10.  Disrupted communication between late-stage premalignant human colon epithelial cells by 12-O tetradecanoylphorbol-13-acetate.

Authors:  E A Friedman; M Steinberg
Journal:  Cancer Res       Date:  1982-12       Impact factor: 12.701
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  5 in total

1.  The effect of complete carcinogens on intercellular transfer of lucifer yellow in fibroblast culture.

Authors:  I V Budunova; L A Mittelman; G A Belitsky
Journal:  Cell Biol Toxicol       Date:  1990-01       Impact factor: 6.691

2.  The effect of K+/H+ antiporter nigericin on gap junction permeability.

Authors:  I V Budunova; L A Mittelman
Journal:  Cell Biol Toxicol       Date:  1992 Jan-Mar       Impact factor: 6.691

3.  Effect of tumor promoting stimuli on gap junction permeability and connexin43 expression in ARL18 rat liver cell line.

Authors:  I V Budunova; G M Williams; D C Spray
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

Review 4.  Cell culture assays for chemicals with tumor-promoting or tumor-inhibiting activity based on the modulation of intercellular communication.

Authors:  I V Budunova; G M Williams
Journal:  Cell Biol Toxicol       Date:  1994-04       Impact factor: 6.691

5.  The carcinogen benzo(e)pyrene is metabolized by DM15 cells without an uncoupling effect on their gap junctions.

Authors:  I V Budunova; L A Mittleman; R D Safaev; G A Belitsky
Journal:  Cell Biol Toxicol       Date:  1993 Apr-Jun       Impact factor: 6.691
  5 in total

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