Literature DB >> 7172417

Promoting effects of phenobarbital and barbital on development of thyroid tumors in rats treated with N-bis(2-hydroxypropyl)nitrosamine.

Y Hiasa, Y Kitahori, M Ohshima, T Fujita, T Yuasa, N Konishi, A Miyashiro.   

Abstract

Phenobarbital (PB) and barbital (BB) promoted the development of thyroid tumors in rats treated with a sub-effective dose of N-bis(2-hydroxypropyl)nitrosamine (DHPN) for thyroid tumorigenesis. Rats were given s.c. injections of 70 mg DHPN/100 g body weight once a week for 4 or 6 weeks with or without diet containing 500 p.p.m. PB or BB for the next 12 weeks. The incidences of thyroid tumors at the end of week 20 of the experiment were 66% in rats given DHPN for 4 weeks and then PB, 23% in rats given DHPN for 4 weeks and then BB, 100% in rats given DHPN for 6 weeks and then PB, 45% in rats given DHPN for 6 weeks and then BB, and 23% in rats given DHPN for 6 weeks. Rats given only DHPN for 4 weeks or only PB or BB had no thyroid tumors after 20 weeks.

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Year:  1982        PMID： 7172417     DOI： 10.1093/carcin/3.10.1187

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  9 in total

1.  Ras gene mutation-independent tumours in the intestine of the rat by a single dose of N-methyl-N-nitrosourea.

Authors:  V Waldmann; H M Rabes
Journal:  Int J Exp Pathol       Date:  1992-08       Impact factor: 1.925

2.  Identification of tumor promoters by their inhibitory effect on intercellular transfer of lucifer yellow.

Authors:  I V Budunova; L A Mittelman; G A Belitsky
Journal:  Cell Biol Toxicol       Date:  1989-01       Impact factor: 6.691

3.  Role of NKX2-1 in N-bis(2-hydroxypropyl)-nitrosamine-induced thyroid adenoma in mice.

Authors:  Sayuri Hoshi; Nobuo Hoshi; Minoru Okamoto; Jorge Paiz; Takashi Kusakabe; Jerrold M Ward; Shioko Kimura
Journal:  Carcinogenesis       Date:  2009-07-06       Impact factor: 4.944

4.  Phenobarbital use and bladder cancer risk.

Authors:  J E Castelao; M Gago-Dominguez; J M Yuan; R K Ross; M C Yu
Journal:  Eur J Epidemiol       Date:  2003       Impact factor: 8.082

5.  Dose- and sex-related carcinogenesis by N-bis(2-hydroxypropyl)nitrosamine in Wistar rats.

Authors:  E L Moreira; J L de Camargo; M A Rodrigues; L F Barbisan; D M Salvadori
Journal:  Jpn J Cancer Res       Date:  2000-04

6.  An approach to the determination of the relative potencies of chemical agents during the stages of initiation and promotion in multistage hepatocarcinogenesis in the rat.

Authors:  H C Pitot; H A Campbell
Journal:  Environ Health Perspect       Date:  1987-12       Impact factor: 9.031

7.  Effects of phenobarbital and carbazole on carcinogenesis of the lung, thyroid, kidney, and bladder of rats pretreated with N-bis(2-hydroxypropyl)nitrosamine.

Authors:  T Shirai; A Masuda; K Imaida; T Ogiso; N Ito
Journal:  Jpn J Cancer Res       Date:  1988-04

8.  The promoting effects of food dyes, erythrosine (Red 3) and rose bengal B (Red 105), on thyroid tumors in partially thyroidectomized N-bis(2-hydroxypropyl)-nitrosamine-treated rats.

Authors:  Y Hiasa; M Ohshima; Y Kitahori; N Konishi; T Shimoyama; Y Sakaguchi; H Hashimoto; S Minami; Y Kato
Journal:  Jpn J Cancer Res       Date:  1988-03

9.  Dose-dependent induction of liver and thyroid neoplastic lesions by short-term administration of 2-amino-3-methylimidazo[4,5-f]quinoline combined with partial hepatectomy followed by phenobarbital or low dose 3'-methyl-4-dimethylaminoazobenzene promotion.

Authors:  H Tsuda; M Asamoto; T Ogiso; T Inoue; N Ito; M Nagao
Journal:  Jpn J Cancer Res       Date:  1988-06
  9 in total

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