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Literature DB >> 493994

Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.

Abstract

Wild-type Chinese hamster V79 cells (6-thioguanine-sensitive) reduce the recovery of 6-thioguanine-resistant cells when they are cultured together at high densities, through a form of intercellular communication (metabolic cooperation). Cooperation is inhibited by 12-O-tetradecanoyl phorbol-13-acetate, rescuing the 6-thioguanine-resistant cells. These results may be useful in the study of an aspect of the mechanism of tumor promotion and in assaying for promoters.

Entities: Chemical Disease Species

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Year: 1979 PMID： 493994 DOI： 10.1126/science.493994

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

94 in total

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3. Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth.

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5. Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products.

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10. Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways.

Authors: Chung-Hsun Lee; I-Hui Chen; Chia-Rong Lee; Chih-Hsien Chi; Ming-Che Tsai; Jin-Lian Tsai; Hsiu-Fen Lin
Journal: J Occup Med Toxicol Date: 2010-06-30 Impact factor: 2.646

Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter.

1. Inhibition of intercellular communication by airborne particulate matter.

2. Limitations of the scrape-loading/dye transfer technique to quantify inhibition of gap junctional intercellular communication.

3. Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth.

Review 4. Human adult stem cells as the target cells for the initiation of carcinogenesis and for the generation of "cancer stem cells".

5. Gap Junctional Intercellular Communication: A Functional Biomarker to Assess Adverse Effects of Toxicants and Toxins, and Health Benefits of Natural Products.

Review 6. Junctional communication and cellular differentiation.

7. Potential role of the src gene product in inhibition of gap-junctional communication in NIH/3T3 cells.

8. Combinational treatment of gap junctional activator and tamoxifen in breast cancer cells.

9. Granuloma pouch assay. III. Enhancement of the carcinogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.

10. Inhibition of gap junctional Intercellular communication in WB-F344 rat liver epithelial cells by triphenyltin chloride through MAPK and PI3-kinase pathways.