Literature DB >> 24913165

Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

Meredith S Wright1, Federico Perez2, Lauren Brinkac1, Michael R Jacobs3, Keith Kaye4, Eric Cober5, David van Duin6, Steven H Marshall2, Andrea M Hujer7, Susan D Rudin7, Kristine M Hujer7, Robert A Bonomo8, Mark D Adams9.   

Abstract

Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the bla(KPC) genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The bla(KPC) gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24913165      PMCID： PMC4136011          DOI： 10.1128/AAC.00125-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  31 in total

1.  Carbapenem-resistant Klebsiella pneumoniae exhibit variability in capsular polysaccharide and capsule associated virulence traits.

Authors:  Elizabeth Diago-Navarro; Liang Chen; Virginie Passet; Seth Burack; Amaia Ulacia-Hernando; Rosy Priya Kodiyanplakkal; Michael H Levi; Sylvain Brisse; Barry N Kreiswirth; Bettina C Fries
Journal:  J Infect Dis       Date:  2014-03-14       Impact factor: 5.226

2.  Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.

Authors:  Frank R Deleo; Liang Chen; Stephen F Porcella; Craig A Martens; Scott D Kobayashi; Adeline R Porter; Kalyan D Chavda; Michael R Jacobs; Barun Mathema; Randall J Olsen; Robert A Bonomo; James M Musser; Barry N Kreiswirth
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-17       Impact factor: 11.205

3.  Complete sequence of a bla(KPC-2)-harboring IncFII(K1) plasmid from a Klebsiella pneumoniae sequence type 258 strain.

Authors:  Liang Chen; Kalyan D Chavda; Roberto G Melano; Michael R Jacobs; Michael H Levi; Robert A Bonomo; Barry N Kreiswirth
Journal:  Antimicrob Agents Chemother       Date:  2013-01-07       Impact factor: 5.191

4.  Surveillance of carbapenem-resistant Klebsiella pneumoniae: tracking molecular epidemiology and outcomes through a regional network.

Authors:  David van Duin; Federico Perez; Susan D Rudin; Eric Cober; Jennifer Hanrahan; Julie Ziegler; Raymond Webber; Jacqueline Fox; Pamela Mason; Sandra S Richter; Marianne Cline; Geraldine S Hall; Keith S Kaye; Michael R Jacobs; Robert C Kalayjian; Robert A Salata; Julia A Segre; Sean Conlan; Scott Evans; Vance G Fowler; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2014-05-05       Impact factor: 5.191

5.  Secretion, but not overall synthesis, of catecholate siderophores contributes to virulence of extraintestinal pathogenic Escherichia coli.

Authors:  Mélissa Caza; François Lépine; Charles M Dozois
Journal:  Mol Microbiol       Date:  2011-02-24       Impact factor: 3.501

Review 6.  Carbapenemase-producing Enterobacteriaceae: overview of a major public health challenge.

Authors:  P Nordmann
Journal:  Med Mal Infect       Date:  2013-12-18       Impact factor: 2.152

7.  Complete nucleotide sequences of blaKPC-4- and blaKPC-5-harboring IncN and IncX plasmids from Klebsiella pneumoniae strains isolated in New Jersey.

Authors:  Liang Chen; Kalyan D Chavda; Henry S Fraimow; José R Mediavilla; Roberto G Melano; Michael R Jacobs; Robert A Bonomo; Barry N Kreiswirth
Journal:  Antimicrob Agents Chemother       Date:  2012-10-31       Impact factor: 5.191

8.  Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene.

Authors:  Gaelle Cuzon; Thierry Naas; HaVy Truong; Maria Virginia Villegas; Karin T Wisell; Yehuda Carmeli; Ana C Gales; Shiri Navon Venezia; John P Quinn; Patrice Nordmann
Journal:  Emerg Infect Dis       Date:  2010-09       Impact factor: 6.883

9.  Pyrosequencing-based analysis reveals a novel capsular gene cluster in a KPC-producing Klebsiella pneumoniae clinical isolate identified in Brazil.

Authors:  Pablo Ivan Pereira Ramos; Renata Cristina Picão; Eliana Carolina Vespero; Marsileni Pelisson; Luiz Fernando Goda Zuleta; Luiz Gonzaga P Almeida; Alexandra L Gerber; Ana Tereza R Vasconcelos; Ana Cristina Gales; Marisa Fabiana Nicolás
Journal:  BMC Microbiol       Date:  2012-08-11       Impact factor: 3.605

10.  Vital signs: carbapenem-resistant Enterobacteriaceae.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2013-03-08       Impact factor: 17.586
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  41 in total

1.  Genomic epidemiology of Klebsiella pneumoniae in Italy and novel insights into the origin and global evolution of its resistance to carbapenem antibiotics.

Authors:  Stefano Gaiarsa; Francesco Comandatore; Paolo Gaibani; Marta Corbella; Claudia Dalla Valle; Sara Epis; Erika Scaltriti; Edoardo Carretto; Claudio Farina; Maria Labonia; Maria Paola Landini; Stefano Pongolini; Vittorio Sambri; Claudio Bandi; Piero Marone; Davide Sassera
Journal:  Antimicrob Agents Chemother       Date:  2014-11-03       Impact factor: 5.191

2.  Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan.

Authors:  Yi-Hsiang Cheng; Tzu-Lung Lin; Yi-Jiun Pan; Yu-Ping Wang; Yi-Tsung Lin; Jin-Town Wang
Journal:  Antimicrob Agents Chemother       Date:  2015-02-17       Impact factor: 5.191

3.  Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae.

Authors:  Anubhav Kanwar; Steven H Marshall; Federico Perez; Myreen Tomas; Michael R Jacobs; Andrea M Hujer; T Nicholas Domitrovic; Susan D Rudin; Laura J Rojas; Barry N Kreiswirth; Liang Chen; Miguel Quinones-Mateu; David van Duin; Robert A Bonomo
Journal:  Open Forum Infect Dis       Date:  2018-04-23       Impact factor: 3.835

Review 4.  Mobile Genetic Elements Associated with Antimicrobial Resistance.

Authors:  Sally R Partridge; Stephen M Kwong; Neville Firth; Slade O Jensen
Journal:  Clin Microbiol Rev       Date:  2018-08-01       Impact factor: 26.132

5.  Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health.

Authors:  Kathryn E Holt; Heiman Wertheim; Ruth N Zadoks; Stephen Baker; Chris A Whitehouse; David Dance; Adam Jenney; Thomas R Connor; Li Yang Hsu; Juliëtte Severin; Sylvain Brisse; Hanwei Cao; Jonathan Wilksch; Claire Gorrie; Mark B Schultz; David J Edwards; Kinh Van Nguyen; Trung Vu Nguyen; Trinh Tuyet Dao; Martijn Mensink; Vien Le Minh; Nguyen Thi Khanh Nhu; Constance Schultsz; Kuntaman Kuntaman; Paul N Newton; Catrin E Moore; Richard A Strugnell; Nicholas R Thomson
Journal:  Proc Natl Acad Sci U S A       Date:  2015-06-22       Impact factor: 11.205

6.  Genomic and transcriptomic analyses of colistin-resistant clinical isolates of Klebsiella pneumoniae reveal multiple pathways of resistance.

Authors:  Meredith S Wright; Yo Suzuki; Marcus B Jones; Steven H Marshall; Susan D Rudin; David van Duin; Keith Kaye; Michael R Jacobs; Robert A Bonomo; Mark D Adams
Journal:  Antimicrob Agents Chemother       Date:  2014-11-10       Impact factor: 5.191

7.  Pneumonia and Renal Replacement Therapy Are Risk Factors for Ceftazidime-Avibactam Treatment Failures and Resistance among Patients with Carbapenem-Resistant Enterobacteriaceae Infections.

Authors:  Ryan K Shields; M Hong Nguyen; Liang Chen; Ellen G Press; Barry N Kreiswirth; Cornelius J Clancy
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

8.  Impact of therapy and strain type on outcomes in urinary tract infections caused by carbapenem-resistant Klebsiella pneumoniae.

Authors:  David van Duin; Eric Cober; Sandra S Richter; Federico Perez; Robert C Kalayjian; Robert A Salata; Scott Evans; Vance G Fowler; Keith S Kaye; Robert A Bonomo
Journal:  J Antimicrob Chemother       Date:  2014-12-09       Impact factor: 5.790

Review 9.  Treatment options for infections caused by carbapenem-resistant Enterobacteriaceae: can we apply "precision medicine" to antimicrobial chemotherapy?

Authors:  Federico Perez; Nadim G El Chakhtoura; Krisztina M Papp-Wallace; Brigid M Wilson; Robert A Bonomo
Journal:  Expert Opin Pharmacother       Date:  2016-03-09       Impact factor: 3.889

10.  Nosocomial Outbreak of Extensively Drug-Resistant Acinetobacter baumannii Isolates Containing blaOXA-237 Carried on a Plasmid.

Authors:  Andrea M Hujer; Paul G Higgins; Susan D Rudin; Genevieve L Buser; Steven H Marshall; Kyriaki Xanthopoulou; Harald Seifert; Laura J Rojas; T Nicholas Domitrovic; P Maureen Cassidy; Margaret C Cunningham; Robert Vega; Jon P Furuno; Christopher D Pfeiffer; Zintars G Beldavs; Meredith S Wright; Michael R Jacobs; Mark D Adams; Robert A Bonomo
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191
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