Literature DB >> 30014001

Emergence of Resistance to Colistin During the Treatment of Bloodstream Infection Caused by Klebsiella pneumoniae Carbapenemase-Producing Klebsiella pneumoniae.

Anubhav Kanwar1,2, Steven H Marshall3, Federico Perez1,3,2,4, Myreen Tomas1, Michael R Jacobs5, Andrea M Hujer3,4, T Nicholas Domitrovic3,4, Susan D Rudin3,4, Laura J Rojas3,6, Barry N Kreiswirth7, Liang Chen7, Miguel Quinones-Mateu1,6, David van Duin8, Robert A Bonomo1,3,2,4,6,9,10,11.   

Abstract

We report the emergence of colistin resistance in Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae after 8 days of colistin-based therapy, resulting in relapse of bloodstream infection and death. Disruption of the mgrB gene by insertion of a mobile genetic element was found to be the mechanism, which was replicated in vitro after exposure to subinhibitory concentrations of colistin and meropenem.

Entities:  

Keywords:  Klebsiella pneumoniae; carbapenemase; colistin resistance

Year:  2018        PMID： 30014001      PMCID： PMC5913667          DOI： 10.1093/ofid/ofy054

Source DB:  PubMed          Journal:  Open Forum Infect Dis        ISSN： 2328-8957            Impact factor:   3.835


  12 in total

1.  Basic local alignment search tool.

Authors:  S F Altschul; W Gish; W Miller; E W Myers; D J Lipman
Journal:  J Mol Biol       Date:  1990-10-05       Impact factor: 5.469

2.  Effects of Stress, Reactive Oxygen Species, and the SOS Response on De Novo Acquisition of Antibiotic Resistance in Escherichia coli.

Authors:  Nadine Händel; Marloes Hoeksema; Marina Freijo Mata; Stanley Brul; Benno H ter Kuile
Journal:  Antimicrob Agents Chemother       Date:  2015-12-14       Impact factor: 5.191

3.  The comprehensive antibiotic resistance database.

Authors:  Andrew G McArthur; Nicholas Waglechner; Fazmin Nizam; Austin Yan; Marisa A Azad; Alison J Baylay; Kirandeep Bhullar; Marc J Canova; Gianfranco De Pascale; Linda Ejim; Lindsay Kalan; Andrew M King; Kalinka Koteva; Mariya Morar; Michael R Mulvey; Jonathan S O'Brien; Andrew C Pawlowski; Laura J V Piddock; Peter Spanogiannopoulos; Arlene D Sutherland; Irene Tang; Patricia L Taylor; Maulik Thaker; Wenliang Wang; Marie Yan; Tennison Yu; Gerard D Wright
Journal:  Antimicrob Agents Chemother       Date:  2013-05-06       Impact factor: 5.191

4.  Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.

Authors:  Frank R Deleo; Liang Chen; Stephen F Porcella; Craig A Martens; Scott D Kobayashi; Adeline R Porter; Kalyan D Chavda; Michael R Jacobs; Barun Mathema; Randall J Olsen; Robert A Bonomo; James M Musser; Barry N Kreiswirth
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-17       Impact factor: 11.205

5.  Identification of plasmids by PCR-based replicon typing.

Authors:  Alessandra Carattoli; Alessia Bertini; Laura Villa; Vincenzo Falbo; Katie L Hopkins; E John Threlfall
Journal:  J Microbiol Methods       Date:  2005-06-02       Impact factor: 2.363

6.  Effects of Klebsiella pneumoniae carbapenemase subtypes, extended-spectrum β-lactamases, and porin mutations on the in vitro activity of ceftazidime-avibactam against carbapenem-resistant K. pneumoniae.

Authors:  Ryan K Shields; Cornelius J Clancy; Binghua Hao; Liang Chen; Ellen G Press; Nicole M Iovine; Barry N Kreiswirth; M Hong Nguyen
Journal:  Antimicrob Agents Chemother       Date:  2015-07-13       Impact factor: 5.191

7.  Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.

Authors:  Laura J Rojas; Madiha Salim; Eric Cober; Sandra S Richter; Federico Perez; Robert A Salata; Robert C Kalayjian; Richard R Watkins; Steve Marshall; Susan D Rudin; T Nicholas Domitrovic; Andrea M Hujer; Kristine M Hujer; Yohei Doi; Keith S Kaye; Scott Evans; Vance G Fowler; Robert A Bonomo; David van Duin
Journal:  Clin Infect Dis       Date:  2017-03-15       Impact factor: 9.079

8.  Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

Authors:  Meredith S Wright; Federico Perez; Lauren Brinkac; Michael R Jacobs; Keith Kaye; Eric Cober; David van Duin; Steven H Marshall; Andrea M Hujer; Susan D Rudin; Kristine M Hujer; Robert A Bonomo; Mark D Adams
Journal:  Antimicrob Agents Chemother       Date:  2014-06-09       Impact factor: 5.191

9.  In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoP mgrB regulator.

Authors:  Antonio Cannatelli; Marco Maria D'Andrea; Tommaso Giani; Vincenzo Di Pilato; Fabio Arena; Simone Ambretti; Paolo Gaibani; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2013-08-26       Impact factor: 5.191

10.  Identification of acquired antimicrobial resistance genes.

Authors:  Ea Zankari; Henrik Hasman; Salvatore Cosentino; Martin Vestergaard; Simon Rasmussen; Ole Lund; Frank M Aarestrup; Mette Voldby Larsen
Journal:  J Antimicrob Chemother       Date:  2012-07-10       Impact factor: 5.790
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  3 in total

Review 1.  Metallo-β-Lactamases: Structure, Function, Epidemiology, Treatment Options, and the Development Pipeline.

Authors:  Sara E Boyd; David M Livermore; David C Hooper; William W Hope
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

2.  A Longitudinal Nine-Year Study of the Molecular Epidemiology of Carbapenemase-Producing Enterobacterales Isolated From a Regional Hospital in Taiwan: Predominance of Carbapenemase KPC-2 and OXA-48.

Authors:  Tran Thi Thuy Duong; Ya-Min Tsai; Li-Li Wen; Hui-Chuan Chiu; Pek Kee Chen; Tran Thi Dieu Thuy; Pei-Yun Kuo; Jazon Harl Hidrosollo; Shining Wang; Yen-Zhen Zhang; Wei-Hung Lin; Ming-Cheng Wang; Cheng-Yen Kao
Journal:  Front Microbiol       Date:  2022-03-11       Impact factor: 5.640

3.  Genetic Diversity of Virulent Polymyxin-Resistant Klebsiella aerogenes Isolated from Intensive Care Units.

Authors:  Kesia Esther da Silva; Gleyce Hellen de Almeida de Souza; Quézia Moura; Luana Rossato; Letícia Cristina Limiere; Nathalie Gaebler Vasconcelos; Simone Simionatto
Journal:  Antibiotics (Basel)       Date:  2022-08-19
  3 in total

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