Literature DB >> 25691646

Colistin resistance mechanisms in Klebsiella pneumoniae strains from Taiwan.

Yi-Hsiang Cheng1, Tzu-Lung Lin1, Yi-Jiun Pan1, Yu-Ping Wang2, Yi-Tsung Lin2, Jin-Town Wang3.   

Abstract

Colistin is one of the antibiotics of last resort for the treatment of carbapenem-resistant Klebsiella pneumoniae infection. This study showed that capsular type K64 (50%) and ST11 (53.9%) are the prevalent capsular and sequence types in the colistin-resistant strains in Taiwan. The interruption of transcripts (38.5%) and amino acid mutation (15.4%) in mgrB are the major mechanisms contributing to colistin resistance. In addition, novel single amino acid changes in MgrB (Stop48Tyr) and PhoQ (Leu26Pro) were observed to contribute to colistin resistance.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25691646      PMCID： PMC4394772          DOI： 10.1128/AAC.04763-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  41 in total

1.  Emergence of carbapenem resistance due to porin loss in an extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae strain during meropenem therapy.

Authors:  D P Webster; T Gaulton; N Woodford; R Pike; J Turton; C Perry; I C J W Bowler
Journal:  Int J Antimicrob Agents       Date:  2010-09-24       Impact factor: 5.283

2.  Emergence of colistin resistance in Klebsiella pneumoniae from veterinary medicine.

Authors:  Nicolas Kieffer; Laurent Poirel; Patrice Nordmann; Jean-Yves Madec; Marisa Haenni
Journal:  J Antimicrob Chemother       Date:  2014-11-26       Impact factor: 5.790

3.  Resistance to the antimicrobial peptide polymyxin requires myristoylation of Escherichia coli and Salmonella typhimurium lipid A.

Authors:  An X Tran; Melissa E Lester; Christopher M Stead; Christian R H Raetz; Duncan J Maskell; Sara C McGrath; Robert J Cotter; M Stephen Trent
Journal:  J Biol Chem       Date:  2005-06-10       Impact factor: 5.157

Review 4.  Pyogenic liver abscess with a focus on Klebsiella pneumoniae as a primary pathogen: an emerging disease with unique clinical characteristics.

Authors:  Edith R Lederman; Nancy F Crum
Journal:  Am J Gastroenterol       Date:  2005-02       Impact factor: 10.864

5.  Transmembrane polar interactions are required for signaling in the Escherichia coli sensor kinase PhoQ.

Authors:  Shalom D Goldberg; Graham D Clinthorne; Mark Goulian; William F DeGrado
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-19       Impact factor: 11.205

6.  Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa.

Authors:  Joseph B McPhee; Manjeet Bains; Geoff Winsor; Shawn Lewenza; Agnieszka Kwasnicka; Michelle D Brazas; Fiona S L Brinkman; R E W Hancock
Journal:  J Bacteriol       Date:  2006-06       Impact factor: 3.490

7.  Combined porin loss and extended spectrum beta-lactamase production is associated with an increasing imipenem minimal inhibitory concentration in clinical Klebsiella pneumoniae strains.

Authors:  Duo Yang; Yu Guo; Zheng Zhang
Journal:  Curr Microbiol       Date:  2009-02-14       Impact factor: 2.188

8.  Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43.

Authors:  Hsin-Yao Cheng; Yi-Fong Chen; Hwei-Ling Peng
Journal:  J Biomed Sci       Date:  2010-07-24       Impact factor: 8.410

9.  An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli.

Authors:  Aixin Yan; Ziqiang Guan; Christian R H Raetz
Journal:  J Biol Chem       Date:  2007-10-10       Impact factor: 5.157

10.  Feedback inhibition in the PhoQ/PhoP signaling system by a membrane peptide.

Authors:  Andrew M Lippa; Mark Goulian
Journal:  PLoS Genet       Date:  2009-12-24       Impact factor: 5.917
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  57 in total

1.  Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae.

Authors:  Fabio Arena; Lucia Henrici De Angelis; Antonio Cannatelli; Vincenzo Di Pilato; Marina Amorese; Marco Maria D'Andrea; Tommaso Giani; Gian Maria Rossolini
Journal:  Antimicrob Agents Chemother       Date:  2016-03-25       Impact factor: 5.191

Review 2.  Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes.

Authors:  Laurent Poirel; Aurélie Jayol; Patrice Nordmann
Journal:  Clin Microbiol Rev       Date:  2017-04       Impact factor: 26.132

3.  mgrB Mutations Mediating Polymyxin B Resistance in Klebsiella pneumoniae Isolates from Rectal Surveillance Swabs in Brazil.

Authors:  Caio Augusto Martins Aires; Polyana Silva Pereira; Marise Dutra Asensi; Ana Paula D'Alincourt Carvalho-Assef
Journal:  Antimicrob Agents Chemother       Date:  2016-10-21       Impact factor: 5.191

4.  Molecular Typing, Characterization of Antimicrobial Resistance, Virulence Profiling and Analysis of Whole-Genome Sequence of Clinical Klebsiella pneumoniae Isolates.

Authors:  Andrey Shelenkov; Yulia Mikhaylova; Yuri Yanushevich; Andrei Samoilov; Lyudmila Petrova; Valeria Fomina; Vitaly Gusarov; Mikhail Zamyatin; Dmitriy Shagin; Vasiliy Akimkin
Journal:  Antibiotics (Basel)       Date:  2020-05-17

5.  Elucidating the Pharmacokinetics/Pharmacodynamics of Aerosolized Colistin against Multidrug-Resistant Acinetobacter baumannii and Klebsiella pneumoniae in a Mouse Lung Infection Model.

Authors:  Yu-Wei Lin; Qi Tony Zhou; Mei-Ling Han; Ke Chen; Nikolas J Onufrak; Jiping Wang; John D Turnidge; Benjamin P Howden; Alan Forrest; Hak-Kim Chan; Jian Li
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

6.  Missense Mutations in the CrrB Protein Mediate Odilorhabdin Derivative Resistance in Klebsiella pneumoniae.

Authors:  Lucile Pantel; Paulo Juarez; Marine Serri; Lilia Boucinha; Emilie Lessoud; Anne Lanois; Alain Givaudan; Emilie Racine; Maxime Gualtieri
Journal:  Antimicrob Agents Chemother       Date:  2021-03-08       Impact factor: 5.191

7.  Genomic Insights into Colistin-Resistant Klebsiella pneumoniae from a Tunisian Teaching Hospital.

Authors:  Nadia Jaidane; Rémy A Bonnin; Wejdene Mansour; Delphine Girlich; Elodie Creton; Garance Cotellon; Cherifa Chaouch; Noureddine Boujaafar; Olfa Bouallegue; Thierry Naas
Journal:  Antimicrob Agents Chemother       Date:  2018-01-25       Impact factor: 5.191

8.  Acquisition of Broad-Spectrum Cephalosporin Resistance Leading to Colistin Resistance in Klebsiella pneumoniae.

Authors:  Aurélie Jayol; Patrice Nordmann; Marine Desroches; Jean-Winoc Decousser; Laurent Poirel
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

9.  Multifaceted mechanisms of colistin resistance revealed by genomic analysis of multidrug-resistant Klebsiella pneumoniae isolates from individual patients before and after colistin treatment.

Authors:  Yan Zhu; Irene Galani; Ilias Karaiskos; Jing Lu; Su Mon Aye; Jiayuan Huang; Heidi H Yu; Tony Velkov; Helen Giamarellou; Jian Li
Journal:  J Infect       Date:  2019-07-30       Impact factor: 6.072

10.  Amino Acid Substitutions of CrrB Responsible for Resistance to Colistin through CrrC in Klebsiella pneumoniae.

Authors:  Yi-Hsiang Cheng; Tzu-Lung Lin; Yi-Tsung Lin; Jin-Town Wang
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191
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