Literature DB >> 24901567

Overcoming Drug Development Bottlenecks With Repurposing: Old drugs learn new tricks.

Stephen M Strittmatter1.   

Abstract

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Year:  2014        PMID： 24901567      PMCID： PMC4371131          DOI： 10.1038/nm.3595

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


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  15 in total

1.  Estrogen - a potential treatment for schizophrenia.

Authors:  J Kulkarni; A Riedel; A R de Castella; P B Fitzgerald; T J Rolfe; J Taffe; H Burger
Journal:  Schizophr Res       Date:  2001-03-01       Impact factor: 4.939

2.  Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.

Authors:  Yan Zhou; Yuan Su; Baolin Li; Feng Liu; John W Ryder; Xin Wu; Patricia A Gonzalez-DeWhitt; Valentina Gelfanova; John E Hale; Patrick C May; Steven M Paul; Binhui Ni
Journal:  Science       Date:  2003-11-14       Impact factor: 47.728

Review 3.  Diagnosing the decline in pharmaceutical R&D efficiency.

Authors:  Jack W Scannell; Alex Blanckley; Helen Boldon; Brian Warrington
Journal:  Nat Rev Drug Discov       Date:  2012-03-01       Impact factor: 84.694

4.  Trial watch: phase II and phase III attrition rates 2011-2012.

Authors:  John Arrowsmith; Philip Miller
Journal:  Nat Rev Drug Discov       Date:  2013-08       Impact factor: 84.694

5.  Second act: Drug repurposing gets a boost as academic researchers join the search for novel uses of existing drugs.

Authors:  Prashant Nair
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-28       Impact factor: 11.205

6.  N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.

Authors:  Laurent F Hennequin; Jack Allen; Jason Breed; Jon Curwen; Michael Fennell; Tim P Green; Christine Lambert-van der Brempt; Rémy Morgentin; Richard A Norman; Annie Olivier; Ludovic Otterbein; Patrick A Plé; Nicolas Warin; Gerard Costello
Journal:  J Med Chem       Date:  2006-11-02       Impact factor: 7.446

7.  Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

Authors:  Jeffrey D Rothstein; Sarjubhai Patel; Melissa R Regan; Christine Haenggeli; Yanhua H Huang; Dwight E Bergles; Lin Jin; Margaret Dykes Hoberg; Svetlana Vidensky; Dorothy S Chung; Shuy Vang Toan; Lucie I Bruijn; Zao-Zhong Su; Pankaj Gupta; Paul B Fisher
Journal:  Nature       Date:  2005-01-06       Impact factor: 49.962

Review 8.  Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury.

Authors:  M A Kopp; T Liebscher; A Niedeggen; S Laufer; B Brommer; G J Jungehulsing; S M Strittmatter; U Dirnagl; J M Schwab
Journal:  Cell Tissue Res       Date:  2012-02-21       Impact factor: 5.249

9.  Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth.

Authors:  Xingxing Wang; Stephane Budel; Kenneth Baughman; Grahame Gould; Kang-Ho Song; Stephen M Strittmatter
Journal:  J Neurotrauma       Date:  2009-01       Impact factor: 5.269

Review 10.  Fyn kinase inhibition as a novel therapy for Alzheimer's disease.

Authors:  Haakon B Nygaard; Christopher H van Dyck; Stephen M Strittmatter
Journal:  Alzheimers Res Ther       Date:  2014-02-05       Impact factor: 6.982
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  66 in total

1.  Neuroprotective Properties of a Macrolide Antibiotic in a Mouse Model of Middle Cerebral Artery Occlusion: Characterization of the Immunomodulatory Effects and Validation of the Efficacy of Intravenous Administration.

Authors:  Diana Amantea; Michelangelo Certo; Francesco Petrelli; Giacinto Bagetta
Journal:  Assay Drug Dev Technol       Date:  2016-07-08       Impact factor: 1.738

2.  [Leukocyte count of puerperal sows].

Authors:  D Mäde; G Wujanz
Journal:  Berl Munch Tierarztl Wochenschr       Date:  1996-09       Impact factor: 0.328

3.  Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target.

Authors:  Xiao-Yi Zeng; Hao Wang; Fang Bai; Xiu Zhou; Song-Pei Li; Lu-Ping Ren; Ruo-Qiong Sun; Charlie C L Xue; Hua-Liang Jiang; Li-Hong Hu; Ji-Ming Ye
Journal:  Br J Pharmacol       Date:  2015-07-14       Impact factor: 8.739

Review 4.  Drug Repurposing in Parkinson's Disease.

Authors:  Dilan Athauda; Thomas Foltynie
Journal:  CNS Drugs       Date:  2018-08       Impact factor: 5.749

5.  Formulation and evaluation of itraconazole liposomes for Hedgehog pathway inhibition.

Authors:  Jennifer R Pace; Rajan Jog; Diane J Burgess; M Kyle Hadden
Journal:  J Liposome Res       Date:  2019-10-02       Impact factor: 3.648

Review 6.  Repurposing anticancer drugs for targeting necroptosis.

Authors:  Simone Fulda
Journal:  Cell Cycle       Date:  2018-04-25       Impact factor: 4.534

7.  The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.

Authors:  Kristy Koselny; Julianne Green; Louis DiDone; Justin P Halterman; Annette W Fothergill; Nathan P Wiederhold; Thomas F Patterson; Melanie T Cushion; Chad Rappelye; Melanie Wellington; Damian J Krysan
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

8.  Recycling drug screen repurposes hydroxyurea as a sensitizer of glioblastomas to temozolomide targeting de novo DNA synthesis, irrespective of molecular subtype.

Authors:  Jian Teng; Seyedali Hejazi; Lotte Hiddingh; Litia Carvalho; Mark C de Gooijer; Hiroaki Wakimoto; Marco Barazas; Marie Tannous; Andrew S Chi; David P Noske; Pieter Wesseling; Thomas Wurdinger; Tracy T Batchelor; Bakhos A Tannous
Journal:  Neuro Oncol       Date:  2018-04-09       Impact factor: 12.300

9.  Zelnorm, an agonist of 5-Hydroxytryptamine 4-receptor, acts as a potential antitumor drug by targeting JAK/STAT3 signaling.

Authors:  Lei Zhang; Qiaoling Song; Xinxin Zhang; Li Li; Ximing Xu; Xiaohan Xu; Xiaoyu Li; Zhuoya Wang; Yuxi Lin; Xin Li; Mengyuan Li; Fan Su; Xin Wang; Peiju Qiu; Huashi Guan; Yu Tang; Wenfang Xu; Jinbo Yang; Chenyang Zhao
Journal:  Invest New Drugs       Date:  2019-05-14       Impact factor: 3.850

10.  Trifluoperazine prolongs the survival of experimental brain metastases by STAT3-dependent lysosomal membrane permeabilization.

Authors:  Xin Zhang; Kaikai Ding; Jianxiong Ji; Himalaya Parajuli; Synnøve Nymark Aasen; Heidi Espedal; Bin Huang; Anjing Chen; Jian Wang; Xingang Li; Frits Thorsen
Journal:  Am J Cancer Res       Date:  2020-02-01       Impact factor: 6.166
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