| Literature DB >> 14615541 |
Yan Zhou1, Yuan Su, Baolin Li, Feng Liu, John W Ryder, Xin Wu, Patricia A Gonzalez-DeWhitt, Valentina Gelfanova, John E Hale, Patrick C May, Steven M Paul, Binhui Ni.
Abstract
A subset of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to preferentially reduce the secretion of the highly amyloidogenic, 42-residue amyloid-beta peptide Abeta42. We found that Rho and its effector, Rho-associated kinase, preferentially regulated the amount of Abeta42 produced in vitro and that only those NSAIDs effective as Rho inhibitors lowered Abeta42. Administration of Y-27632, a selective Rock inhibitor, also preferentially lowered brain levels of Abeta42 in a transgenic mouse model of Alzheimer's disease. Thus, the Rho-Rock pathway may regulate amyloid precursor protein processing, and a subset of NSAIDs can reduce Abeta42 through inhibition of Rho activity.Entities:
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Year: 2003 PMID： 14615541 DOI： 10.1126/science.1090154
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728