The interaction between stent(s) implantation, PICA involvement, and immediate occlusion degree affect symptomatic intracranial spontaneous vertebral artery dissection aneurysm (sis-VADA) recurrence after reconstructive treatment with stent(s)-assisted coiling.

OBJECTIVES: We aimed to evaluate risk factors of sis-VADAs recurrence after reconstructive treatment based on 113 reconstructed lesions.
METHODS: A total of 111 patients (M:F = 68:43; median age, 47 years) with 113 sis-VADAs underwent reconstruction from October 2000 to March 2011, using stent(s) and coils. Treatments and predictors of recurrence were retrospectively analysed.
RESULTS: Fifty-eight sis-VADAs underwent single-stent treatment, and the remaining 55 sis-VADAs underwent treatment with 2-4 overlapping stents. Follow-up angiography was available for 94 sis-VADAs 12 -78 months, with recurrence in ten patients, including seven angiographic recurrences and three post-treatment haemorrhagic recurrences. A higher rate of post-treatment recurrence was observed in the single stent group than in the multiple stents group (p = 0.010). The interaction between stent (s) implantation and immediate occlusion degree (odds ratio [OR] =3.152; 95% confidence interval [CI], 1.293-7.686; p = 0.012), between stent (s) implantation and the posterior inferior cerebellar artery (PICA) involvement (OR = 4.607; 95% CI, 1.172-18.113; p = 0.029), and between PICA involvement and immediate occlusion degree (OR = 5.018; 95% CI, 1.263-19.933; p = 0.022) affect recurrence in the reconstructed sis-VADAs.
CONCLUSIONS: This single centre cohort study indicated that the interaction effect between stent (s) implantation, PICA involvement, and immediate occlusion degree were closely associated with recurrence after reconstructive treatment of sis-VADA. KEY POINTS: The interaction between stent (s) and immediate occlusion degree affect aneurysmal recurrence. The interaction between stent and PICA involvement affect aneurysmal recurrence. The interaction between PICA involvement and immediate occlusion degree affect aneurysmal recurrence.

Introduction

Intracranial vertebral artery dissection (VAD) has emerged as a leading cause of subarachnoid haemorrhage (SAH) and ischemic stroke of the posterior circulation, particularly in young to middle-aged adults [1, 2]. Once the vertebral artery trunk undergoes aneurismal dilatation, a so-called dissection aneurysm forms, increasing the risk of fatal bleeding in the future [3]. Moreover, a study has indicated that the subsequent rupture (n = 14) rate was up to 58 % in ruptured VADAs (n = 24) [4]. Hence, it is crucial to manage acute sis-VADAs in a timely manner. Endovascular treatment [5-7], including deconstructive [6, 7] (i.e., proximal occlusion or internal trapping) and reconstructive techniques [5, 7], has been introduced as a minimally invasive method to treat lesions in deep locations or patients at high risk for surgery-related morbidity and mortality. Among several endovascular techniques, stent-related reconstructive treatment was shown to be better at maintaining the integrity of the PICA and the parent artery in comparison with deconstructive treatments. Moreover, the rate of post-treatment recurrence did not differ between reconstructive and deconstructive treatments [7]. However, post-treatment recurrence secondary to coil compaction and growth of the aneurysm sac remains a major shortcoming of reconstructive treatment. At present, it is still challenging to distinguish unstable aneurysm residuals from non-progressing neck remnants, which are considered to be of crucial importance in deciding which treatment option a patient should be offered.

Although a recent study indicated that involvement of PICA increased the risk of recurrence after endovascular treatment [7], nearly 51.4 % (57/111) of patients in that study were not treated using reconstructive techniques. Additional measures such as the quality of stent implantation and the immediate occlusion degree are also thought to be crucial in predicting post-treatment recurrence. The aim of this study is to identify risk factors of recurrence after reconstructive treatment in a large sample of patients with sis-VADAs.

Materials and methods

The Ethics committee of the Second Military Medical University affiliated Changhai Hospital approved this retrospective study, and all written consents given by the patients were stored in the Changhai hospital database and used for research.

Patients and aneurysms

We reviewed all patients who underwent endovascular treatment for VADAs from October 2000 to March 2011 to identify patients with sis-VADAs that were reconstructed with stent(s) and coils. All subjects met the following inclusion criteria: (1) acute clinical symptoms and signs related to intracranial VADA, which was confirmed by angiography; (2) reconstruction of lesions with stent(s) and coils; and (3) at least one angiographic follow-up, except in cases of re-bleeding or bleeding events after reconstructive treatment. The exclusion criteria included the following: (1) history of traumatic and iatrogenic injury; (2) lesions extending to the extracranial segment or basilar artery; (3) history of deconstructive treatment and/or sole stent(s) for sis-VADAs; (4) un-treated sis-VADAs; and (5) loss to angiographic follow up, except for 3 haemorrhagic events (one re-bleeding and two haemorrhages). A total of 97 consecutive patients (M:F = 62:35; median age, 46 years; range, 27 to 80 years) with 97 sis-VADAs were identified and enrolled in this study. This series consisted of 57 (59 %) ruptured lesions and 40 (41 %) un-ruptured lesions. Clinical and radiographic characteristics, reconstructive treatment methods, and risk factors of recurrence were retrospectively analysed.

Procedures

Patients with acutely ruptured aneurysms received a loading dose of dual antiplatelet medication (300 mg clopidogrel and 300 mg aspirin) 2 hours before the procedure, and patients with unruptured aneurysms received dual antiplatelet premedication (75 mg of clopidogrel and 100 mg of aspirin) each day for three days. All patients received systemic intravenous heparin after the femoral sheath was placed, with the goal of achieving an activated clotting time between 250 to 300 seconds. Reconstructive treatment of the entire dissected segment was performed using coils in conjunction with either a single stent or multiple stents. A balloon-expandable coronary stent was applied in the early period, and self-expanding neurovascular stents were applied in the late period. Post-procedure, some patients (n = 61) were given three days of heparin (40 mg, every 12 hours, hypodermic injection), while some were not (n = 36). All patients were kept on a dual antiplatelet regimen for six weeks with daily clopidogrel (75 mg) and aspirin (100-300 mg), followed indefinitely by aspirin (100 mg) mono-therapy.

Follow-ups

Angiographic follow up was performed using conventional angiography, which was scheduled at six months, again at 12 months, and annually thereafter. The immediate and follow-up occlusion grades were defined as complete obliteration (100 %), near-complete obliteration (≧90 %, including residual dome or base), and partial obliteration (<90 %) [5, 8, 9]. The angiographic results were evaluated independently by two authors (Jian-Min Liu and  Wen-Yuan Zhao), each with 9-13 years of neurointerventional experience. Angiographic recurrence was diagnosed when the contrast medium within the lesions substantially increased in comparison with a control angiogram taken immediately after treatment. Additionally, recurrence was diagnosed when haemorrhage or re-bleeding after treatment occurred in un-ruptured or ruptured sis-VADAs [7, 10], respectively.

Statistical analysis

Statistical analysis was performed using SPSS for Windows (SPSS17.0). An unpaired t test or a Mann-Whitney U test was performed for continuous variables. The x 2 test or Fisher’s exact test was performed for categorical variables. The following variables were analysed: age, sex, presentation (ruptured/unruptured), involvement of the PICA origin, lesion type (dilatation without stenosis or dilatation with stenosis), blood supply to the basilar artery, stent(s) implantation (single stent or multiple stents), immediate occlusion degree, and usage of post-procedural heparin. Univariate analysis were performed to determine the association of post-treatment recurrence with other factors. Logistic regression analysis was performed to determine the independent association of post-treatment recurrence with other factors. The univariate analysis cut-off for inclusion in the logistic regression analysis was p < 0.20. When variables were not independent predictors of recurrence, the interaction between the variables was also determined. A p < 0.05 for a 95 % CI was considered statistically significant.

Results

Treatment

Stent implantation was defined as a successful placement if the deployed single stent or overlapped multiple ones in a telescopic fashion extended at least 5 mm over aneurysmal neck (lateral protrusion-shaped dissection aneurysms) or the border of other dissection lesions (i.e., fusiform-shaped, et al.) on both sides of the target vessel [8]. All inclusion VADAs were successfully reconstructed with coiling combined with either a single stent (n = 50; 31 ruptured, 19 unruptured) or multiple stents (n = 47; 26 ruptured, 21 unruptured). Six patients suffered from adverse events, including one re-bleeding (Case 7) and two bleeding (Case 10,11) (Table 1). One patient was initially treated with triple stents and coils for a ruptured lesion involving the PICA, resulting in immediate PICA occlusion, which might be attributed to coil migration to the origin of the PICA, SAH or both. Two patients (one ruptured, one unruptured) were treated with two or three overlapping stents and coils but died of subsequent ischemic events (one severe cerebral vasospasm-Case 8, one cerebral stem infarction- Case 9). The remaining three patients (one ruptured-Case 7, two unruptured- Case 10,11) underwent reconstructive treatment with one stent (n = 2) or two overlapping stents, which achieved partial obliteration, but they subsequently died due to haemorrhage (n = 2) or re-bleeding (n = 1) 24-48 hours after treatment. Therefore, the peri-procedural complication rate was 6 % among the 97 sis-VADA repairs. Additionally, two patients (one ruptured, one unruptured) were reconstructed with 1-2 stent(s) and coiling, which achieved partial obliteration, but they subsequently died of the suspected haemorrhage event in six months (Case 7) or 26 months (Case 14) after treatment, respectively. The overall mortality rate was 7 % (7/97), but the haemorrhage- or re-bleeding-related mortality was 3 % (3/97). All surviving patients were clinically followed for a mean of 58 months (range, 12-132 months). Clinical outcomes were unfavourable (modified Rankin Scale score, 2-6) in 6 of 40 un-ruptured VADA patients and in 10 of 57 ruptured VADA patients.

Table 1

Data of 10 Recurrences (7 Angiographic, 1 re-bleeding, and 2 bleeding) and 7 deaths

Case	Age/Sex	Rup--ture	H-H	PICA--Involving	Stent (s)	Obliteration	Heparin	Angiographic Recurrence (Intervials)	Clinical Outcome mRS (Intervials)
1	48/M	Yes	2	Yes	Balloon-expandable	Partial	Yes	Yes (12 M)	0 (110 M)
2	27/F	Yes	2	Yes	Neuroform	Partial	Yes	Yes (10 M)	0 (78 M)
3	42/M	Yes	2	Proximal	LEO	Partial	Yes	Yes (3 M)	0 (40 M)
4	49/M	Yes	2	Yes	Enterprise	Partial	Yes	Yes (6 M)	0 (7 M)
5	35/M	Yes	2	Yes	Enterprise	Partial	Yes	Yes (7 M)	1 (27 M)
6	44/F	Yes	1	Yes	LEO	Partial	Yes	No (Suspected re-bleeding)	6 (6 M) Sudden death
7	65/M	Yes	1	Yes	Enterprise	Partial	Yes	No (Re-bleeding)	6 (48 h) (death)
8	54/M	Yes	4	distal	3 Enterprise	Complete	Yes	NA	6 (48 h) death
9	52/F	No	/	distal	2 Neuroform	Partial	No	Complete obliteration (14 M)	6 (21 M) death
10	47/F	No	/	Yes	2 Solitaire	Partial	Yes	Bleeding (24 h)	6 (24 h) (death)
11	58/F	No	/	distal	Enterprise	Partial	Yes	Bleeding (/)	6 (48 h) (death)
12	60/M	No	/	distal	Neuroform	Partial	Yes	Yes (8 M)	0 (72 M)
13	34/M	No	/	Yes	3 Enterprise	Complete	No	Yes (6 M)	0 (40 M)
14	39/M	No	/	Yes	2 Leo	Partial	Yes	No (Suspected re-bleeding)	6 (26 M), Sudden death

M, male; F, female; H-H, Hunt-Hess; PICA, the posterior inferior cerebellar artery; M, month; NA, no available; h, hour; mRS, modified Rankin Scale

Angiographic results

Angiographic follow up was available for 94 sis-VADA patients 12-78 months (mean, 23 months) after treatment. This series included three patients with post-treatment haemorrhagic recurrence, one of whom initially presented with a ruptured lesion and two of whom presented with un-ruptured lesions. Tables 2 and 3 summarize the characteristics of the treated sis-VADAs and risk factors of post-treatment recurrence on univariate analysis, respectively. Although treatment type was not associated with differences between the group with lesions involving the PICA and the group with lesions not involving the PICA (p = 0.230, Table 2) or between patients with ruptured lesions and those with unruptured lesions (p = 0.504, Table 2), multiple stents had the clear preponderance over a single stent in increasing the immediate angiographic occlusion degree (p = 0.011, Table 2). Of the 97 reconstructed lesions, there were ten recurrences (seven angiographic recurrences, one re-bleeding, two haemorrhages), which were more frequently observed in the group with lesions involving the PICA (18 % vs. 5 % in the group with lesions not involving the PICA, p = 0.042, Table 3), in the single-stent group (18 % vs. 2 % in the multiple-stent group, p = 0.010, Table 3), and in the partial obliteration group (18 % vs. 4 % in the complete obliteration group, p = 0.040, Table 3).

Table 2

Data on the initial treatment of 97 sis-VADAs

Variables	Single stent (n = 50)	Multiple stents (n = 47)	Total (n = 97)	p Value
Sex, n (%)				0.660
Male	33 (53)	29 (47)	62
Female	17 (49)	18 (51)	35
Presentation, n (%)				0.504
Ruptured	31 (54)	26 (46)	57
Un-ruptured	19 (48)	21 (52)	40
PICA Involvement				0.230
Yes	23 (59)	16 (41)	39
No	27 (47)	31 (53)	58
Aneurysmal Type, n (%)				0.163
Dilatation without stenosis	26 (46)	31 (54)	57
Dilatation with stenosis	24 (60)	16 (40)	40
Blood Supply to Basilar Artery, n (%)				0.076
Predominant	15 (68)	7 (32)	22
Equal	35 (47)	40 (53)	75
Immediate Angiographic Occlusion Results, n (%)				0.011
Complete Obliteration	7 (27)	19 (73)	26
Near-complete Obliteration	11 (55)	9 (45)	20
Partial Obliteration	32 (63)	19 (37)	51

sis-VADA = symptomatic intracranial spontaneous vertebral artery dissection aneurysm

Table 3

Predictors of sis-VADA Recurrence after Reconstruction by univariate analysis

Variables	Yes (n = 10)	No (n = 87)	Total (n = 97)	p Value
Age, y, Mean ± SD	45.70 ± 12.49	49.53 ± 10.37		0.354
Sex, n (%)
Male	8 (13)	54 (87)	62	0.263
Female	2 (6)	33 (94)	35
Presentation, n (%)
Ruptured	6 (11)	51 (89)	57	0.933
Un-ruptured	4 (10)	36 (90)	40
PICA Involvement, n (%) *				0.042
Yes	7 (18)	32 (82)	39
No	3 (5)	55 (95)	58
Aneurysmal Type, n (%)				0.446
Dilatation without stenosis	7 (12)	50 (88)	57
Dilatation with stenosis	3 (8)	37 (92)	40
Blood Supply to Basilar Artery				0.559
Predominant	3 (14)	19 (86)	22
Equal	7 (9)	68 (91)	75
Stent(s) Implantation, n (%) *				0.010
Single stent + coils	9 (18)	41 (82)	50
Multiple stents + coils	1 (2)	46 (98)	47
Immediate Occlusion Degree, no (%) *				0.040
Complete obliteration	1 (4)	25 (96)	26
Near-complete obliteration	0 (0)	20 (100)	20
Partial obliteration	9 (18)	42 (82)	51
Usage of Post-procedural Heparin				0.237
Yes	8 (13)	53 (87)	61
No	2 (6)	34 (94)	36

The rate of post-treatment recurrence did not differ between patients with ruptured sis-VADAs and those with unruptured sis-VADAs (p = 0.933, Table 3), nor in patients with or without post-procedural heparin for three days. Of the ten recurrences, 90 % (9/10, including one haemorrhage and one re-bleeding) occurred in lesions with partial obliteration after a single stent, 60 % (6/10, including one haemorrhage and one re-bleeding) occurred in lesions involving the PICA with partial obliteration after treatment, and 50 % (5/10, including one re-bleeding) occurred in lesions involving the PICA that were reconstructed using a single stent. Logistic regression analysis indicated that the interaction between stent (s) implantation and immediate occlusion degree (odds ratio[OR] = 3.152; 95 % confidence interval [CI], 1.293-7.686; p = 0.012, on-line Table 4), between stent (s) implantation and PICA involvement (OR = 4.607; 95 % CI, 1.172-18.113; p = 0.029, on-line Table 5), and between PICA involvement and immediate occlusion degree (OR = 5.018; 95 % CI, 1.263-19.933; p = 0.022, on-line Table 6) were closely associated with the reconstructed sis-VADAs recurrence.

Discussion

The instability of coils remains the primary shortcoming of endovascular treatment. Thus, it is necessary to identify patients who will require further treatment. The data published thus far on post-treatment recurrence primarily pertain to saccular aneurysms, and few studies have focused on intracranial VADAs recurrence. Due to differences in aetiology, anatomic configuration, and treatment method, the saccular aneurysm-related predictors of recurrence, such as aneurysm size [11-13], width of the neck [13, 14], treatment during the acute phase after aneurysm rupture [12-14], initially suboptimal angiographic aneurysm occlusion [12-14], and length of follow up [13, 14] could not accurately be applied to sis-VADAs. Recently, our study based on 57 ruptured dissection aneurysms indicated partial obliteration following single-stent-assisted coiling had higher risk of recurrence and re-bleeding [15]. Hence, the interaction between the variables may play a crucial role in the recurrence of reconstructed sis-VADAs. An in-depth investigation facilitated the early recognition of risk factors of post-treatment recurrence, leading to more prompt treatment. This study focused on sis-VADA-related post-treatment recurrence and its predictors. To our knowledge, this study is the first to evaluate predictors of recurrence after reconstructive treatment of sis-VADAs.

Generally, the recurrence and rupture of the reconstructed VADAs were a continuous course. Post-treatment recurrence attributed to antegrade (Fig. 1B) or retrograde (Fig. 1D) coil mass compaction, sac growth (Fig. 1F) or a new dissection formation (Fig. 2B), and a high wall shear stresses (WSS) within the recanalization zone may play critical roles in recurrence [16]. Table 3 indicates that lesions involving the PICA, single-stent reconstructions, and partial obliteration were risk factors for post-treatment recurrence by univariate analysis. However, none of these variables was an independent predictor of recurrence by logistic regression analysis. This finding was inconsistent with a previous study in which PICA involvement was the only independent risk factor for recurrence after the endovascular treatment of vertebrobasilar dissecting aneurysms [7]. These differences could be attributed to differences in treatment method.

Fig. 1

Recurrent sis-VADAs reconstructed using a single stent and coiling. (A-B) A partially occluded VADA, not involving the PICA, recurred due to antegrade coil compaction (white arrow) at 8 months (A) and 1.5 years (B) after single-stent reconstruction. (C-D) A VADA involving the PICA (C, black arrow) was partially occluded (C), occurring retrograde (white arrow) coil compaction (D) 3 months after single-stent reconstruction. (E-F) A partially occluded VADA (E) involving aneurysm sac occurred growth and coil compaction (F) 10 months after single-stent treatment

Fig. 2

sis-VADAs reconstructed with multiple stents and coiling. (A-C) A VADA involving the PICA was reconstructed with three Enterprise stents (A). After 6 months, a recurrence was observed at the origin of the PICA (B) and was effectively retreated with an additional Solitaire AB stent and followed up for 6 months (C). (D-F) A VADA (D) was reconstructed with four overlapping stents, and immediate partial obliteration was achieved (E). An 8-month follow-up angiogram showed normalization (F)

Irrespective of PICA involvement, the interaction effect between stent(s) implantation and immediate occlusion degree was significantly related to post-treatment recurrence (on-line Table 4). Our results demonstrated that nine (90 %, including one haemorrhage and one re-bleeding) of the ten recurrences occurred in lesions with partial obliteration after treatment with a single stent (Fig. 1). Even if the PICA was not involved, this risk remained high (Fig. 1A-1B). By contrast, only one (2 %) of the 47 lesions treated with multiple stents recurred at six months (Fig. 2A-2C) after treatment. On the one hand, overlapping multiple stents were better than single stents in decreasing intra-aneurismal WSS [17-19] which prevented coil compaction and aneurismal rupture and growth. On the other hand, treatment with a single stent led to a higher rate of immediate partial obliteration in comparison with treatment with multiple stents (p = 0.011, Table 2), which was also a risk factor for post-treatment recurrence (Table 3). Previous studies have indicated that the degree of aneurysm occlusion after initial treatment is a strong predictor of the risk of subsequent rupture in patients presenting with subarachnoid haemorrhage [20]. Hence, provided that a lesion is not completely occluded, the use of overlapping multiple stents with lower stent porosity may be an alternative for preventing recurrence or haemorrhagic events, as was also well-documented in flow-diverter devices [21, 22].

The interaction effect between stent(s) implantation and PICA involvement was significantly associated with post-treatment recurrence (on-line Table 5). Our results showed that five (50 %, including one re-bleeding) of the ten recurrences occurred in lesions involving the PICA that were reconstructed using single stent (Fig. 1C-1D); these lesions had the same hemodynamic status as saccular lesions with partial obliteration after single-stent reconstructive treatment. When lesions involving the PICA were reconstructed by a stent, a small portion of the dissecting aneurysm sac was left, which allowed continuous antegrade or retrograde blood flow into the PICA (Fig. 1C), increasing the risk of recurrence (Fig. 1D). Several studies have indicated that aneurysm re-rupture [20] and angiographic recurrence [23-25] are closely related to incomplete aneurysm occlusion. Although stent-associated flow remodeling could cause further occlusion of incompletely coiled aneurysms [26], intracranial dissecting aneurysms (18 %, 7/39, Table 3) recur at a higher rate than do saccular aneurysms (8.3 %-14 % [27, 28]) during follow up when a single stent and coiling was employed. A possible explanation for this difference is the greater fragility of the wall of a dissecting aneurysm than of the wall of a Berry aneurysm. Another possible explanation may be the differing aetiology and more complicated anatomic configurations [29], such as intramural hematomas, pearl-and-string configurations, and intimal flap configurations. Because aneurysm re-canalizations are located in high-WSS areas [16], the use of multiple stents helps prevent recurrence and haemorrhagic events due to greater reductions in WSS [17, 18]. In our series (Fig. 2A-2 F,), only two (4 %, 2/47) patients whose lesions were reconstructed using multiple stents suffered a recurrence (n = 1) or haemorrhagic event (n = 1).

Regardless of whether treatment involved a single stent (Fig. 1C-1D) or multiple stents (Fig. 2A-2B), the interaction effect between PICA involvement and immediate occlusion degree was closely associated with post-treatment recurrence (on-line Table 6). Our results showed that 60 % of the recurrences (6/10, including two haemorrhages) occurred in patients with lesions involving the PICA that were partially obliterated after treatment. Even if partial obliteration was achieved in patients with multiple stents, the post-treatment recurrence risk remained high (Fig. 2A-2B). Although the lesions did not recur in the obliterated region (Fig. 2A-2B), new aneurysms originated from the PICA, which suggested that aneurysm sac growth [30] (Fig. 1E-1 F) may be the recurrence mechanism. Initial PICA involvement with the VADA was closely associated with post-treatment recurrence and re-bleeding in intracranial VADAs [7, 31]. In this series, one patient with a ruptured lesion and one patient with an un-ruptured lesion that were repaired with single stent experienced haemorrhagic events, including one re-bleeding and one haemorrhage. It is possible that low WSS at end-diastole caused degeneration and thinning of the aneurysm wall and that high pressure at peak systole resulted in rupture of the thinning wall [32]. Another underlying mechanism may be related to unfavourable hemodynamic changes (i.e., the outflow being restricted more than the inflow) after reconstructive treatment [33], autolysis of the aneurysm wall secondary to thrombus [34], or both.

Although the outcomes of single stent-assisted coiling for intracranial saccular aneurysms are encouraging [27, 28] single-stent reconstructive treatment of sis-VADAs involves a high risk of recurrence, particularly in lesions involving the PICA and lesions with immediate partial obliteration. In the future, flow-diverter devices, such as the pipeline [21] and silk [22] devices, may be a promising choice for preventing recurrence.

This study suffered from several limitations, including the retrospective design, patient selection bias, and limited number of cases. Additionally, one ruptured and one unruptured lesion resulted in re-bleeding and haemorrhage within 48 hours after initial treatment, respectively. The recurrence and rupture of lesions were continuous in the disease course, and autolysis of the aneurysm secondary to thrombosis formation after treatment may be a cause of delayed aneurysm rupture [35]. Hence, it is reasonable to assume that recurrent VADAs caused the observed haemorrhage or re-bleeding.

In conclusion, this single centre cohort indicated that the interaction between stent(s) implantation and immediate occlusion degree, between stent(s) implantation and PICA involvement, and between PICA involvement and immediate occlusion degree were closely associated with recurrence in the reconstructed sis-VADAs, and multiple stents had the clear preponderance over single stent in preventing recurrence. However, multiple stents seemed be affected by worse morbidity, mortality and outcome based on the result that five of six patients with adverse events received multiple stents treatment. Further study is required to verify these findings.

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