PURPOSE: The aim of this study was to evaluate the osseointegration of a new coating directly deposited on PE at room temperature. METHODS: Thirty-six (36) male New Zealand rabbits were randomly assigned to receive one out of three types of implants: two tested implants, i.e. PE implant coated with TiPVD and biomimetic HA (biomimetic), PE implant coated with TiPVD and electrolytic HA (electrolytic), and positive control made of massive microrough titanium coated with plasma sprayed HA (TiHAPS). Osseointegration was evaluated by histomorphometry (bone tissue in contact [BIC]), mineralized bone area [MBA]) and mechanical testing (push-out test, interfacial shear strength [ISS]) at six and 12 weeks in the distal femurs. RESULTS: For BIC there were no differences between the groups at six (p = 0.98) and 12 weeks (p = 0.13). For MBA, no statistically significant difference was measured between groups at six (p = 0.52) and 12 weeks (p = 0.57). At six weeks, interfacial shear strength (ISS) was significantly higher (p = 0.01) for TiHAPs implants compared to biomimetic and electrolytic implants. This difference was not significant at 12 weeks (p = 0.92). CONCLUSION: The osseointegration of biomimetic and electrolytic implants was equivalent to a positive control at 12 weeks.
PURPOSE: The aim of this study was to evaluate the osseointegration of a new coating directly deposited on PE at room temperature. METHODS: Thirty-six (36) male New Zealand rabbits were randomly assigned to receive one out of three types of implants: two tested implants, i.e. PE implant coated with TiPVD and biomimetic HA (biomimetic), PE implant coated with TiPVD and electrolytic HA (electrolytic), and positive control made of massive microrough titanium coated with plasma sprayed HA (TiHAPS). Osseointegration was evaluated by histomorphometry (bone tissue in contact [BIC]), mineralized bone area [MBA]) and mechanical testing (push-out test, interfacial shear strength [ISS]) at six and 12 weeks in the distal femurs. RESULTS: For BIC there were no differences between the groups at six (p = 0.98) and 12 weeks (p = 0.13). For MBA, no statistically significant difference was measured between groups at six (p = 0.52) and 12 weeks (p = 0.57). At six weeks, interfacial shear strength (ISS) was significantly higher (p = 0.01) for TiHAPs implants compared to biomimetic and electrolytic implants. This difference was not significant at 12 weeks (p = 0.92). CONCLUSION: The osseointegration of biomimetic and electrolytic implants was equivalent to a positive control at 12 weeks.
Authors: Ole Reigstad; Carina Johansson; Victoria Stenport; Ann Wennerberg; Astor Reigstad; Magne Røkkum Journal: J Biomed Mater Res B Appl Biomater Date: 2011-06-06 Impact factor: 3.368
Authors: F Barrère; C M van der Valk; G Meijer; R A J Dalmeijer; K de Groot; P Layrolle Journal: J Biomed Mater Res B Appl Biomater Date: 2003-10-15 Impact factor: 3.368