BACKGROUND: Early detection of infectious complications is urgently needed in the era of DRG-based compensation. This work assessed the diagnostic accuracy of c-reactive protein (CRP) level in the detection of infectious complications after laparoscopic colorectal resection. METHODS: Laparoscopic colorectal resections were identified from a prospective database. Complications were graded according to the Dindo-Clavien classification. Surgical site infections were defined according to the Centers of Disease Control. CRP level was routinely measured until postoperative day (POD) 7. Uni- and multivariate analysis were performed. Diagnostic accuracy was evaluated using receiver operating curves. RESULTS: 355 patients were operated for diverticulosis (88.7%), neoplasia (6.8%), and other causes (4.5%). Mean age and body mass index were 59.8 ± 13.7 years and 26.5 ± 15 kg/m(2). Left, right, and total laparoscopic colectomies were performed in 316, 33, and 6 patients. Complications occurred in 85 patients and 16 patients (4.5%) were reoperated. Fifty-one patients (14.4%) suffered from infectious complications at a median of 6 POD, while 9 anastomoses leaked (2.7%). In multivariate analysis, presence of an abscess at surgery was predictive of an infectious complication (OR 2.5, 95% CI 1.1-5.3), as were a body mass index >30 kg/m(2) and operative time >160 min in a bootstrap analysis. Overall, CRP peaked on POD 2 and declined thereafter. Most infectious complications were apparent starting on POD 6. A CRP <56 mg/l on POD 4 had a negative predictive value of 100% (95% CI 94.9-100%) to rule out infectious complications. Above 56 mg/l, sensitivity was 100% (95% CI 0.8-1) and specificity 49% (95% CI 0.4-0.6) for the development of infectious complications in the absence of clinical signs. This translated into a remarkable diagnostic accuracy of 78% (95% CI 0.7-0.9). CONCLUSION: Monitoring CRP level in laparoscopic colorectal surgery demonstrated a high diagnostic accuracy for infectious complications, thus allowing for safe and early discharge.
BACKGROUND: Early detection of infectious complications is urgently needed in the era of DRG-based compensation. This work assessed the diagnostic accuracy of c-reactive protein (CRP) level in the detection of infectious complications after laparoscopic colorectal resection. METHODS: Laparoscopic colorectal resections were identified from a prospective database. Complications were graded according to the Dindo-Clavien classification. Surgical site infections were defined according to the Centers of Disease Control. CRP level was routinely measured until postoperative day (POD) 7. Uni- and multivariate analysis were performed. Diagnostic accuracy was evaluated using receiver operating curves. RESULTS: 355 patients were operated for diverticulosis (88.7%), neoplasia (6.8%), and other causes (4.5%). Mean age and body mass index were 59.8 ± 13.7 years and 26.5 ± 15 kg/m(2). Left, right, and total laparoscopic colectomies were performed in 316, 33, and 6 patients. Complications occurred in 85 patients and 16 patients (4.5%) were reoperated. Fifty-one patients (14.4%) suffered from infectious complications at a median of 6 POD, while 9 anastomoses leaked (2.7%). In multivariate analysis, presence of an abscess at surgery was predictive of an infectious complication (OR 2.5, 95% CI 1.1-5.3), as were a body mass index >30 kg/m(2) and operative time >160 min in a bootstrap analysis. Overall, CRP peaked on POD 2 and declined thereafter. Most infectious complications were apparent starting on POD 6. A CRP <56 mg/l on POD 4 had a negative predictive value of 100% (95% CI 94.9-100%) to rule out infectious complications. Above 56 mg/l, sensitivity was 100% (95% CI 0.8-1) and specificity 49% (95% CI 0.4-0.6) for the development of infectious complications in the absence of clinical signs. This translated into a remarkable diagnostic accuracy of 78% (95% CI 0.7-0.9). CONCLUSION: Monitoring CRP level in laparoscopic colorectal surgery demonstrated a high diagnostic accuracy for infectious complications, thus allowing for safe and early discharge.
Authors: Rene Warschkow; Ulrich Beutner; Thomas Steffen; Sascha A Müller; Bruno M Schmied; Ulrich Güller; Ignazio Tarantino Journal: Ann Surg Date: 2012-08 Impact factor: 12.969
Authors: Shukri F Khuri; William G Henderson; Ralph G DePalma; Cecilia Mosca; Nancy A Healey; Dharam J Kumbhani Journal: Ann Surg Date: 2005-09 Impact factor: 12.969
Authors: Olivier Facy; Brice Paquette; David Orry; Nicolas Santucci; Paul Rat; Patrick Rat; Christine Binquet; Pablo Ortega-Deballon Journal: Int J Colorectal Dis Date: 2017-04-06 Impact factor: 2.571
Authors: Jennifer Straatman; Annelieke M K Harmsen; Miguel A Cuesta; Johannes Berkhof; Elise P Jansma; Donald L van der Peet Journal: PLoS One Date: 2015-07-15 Impact factor: 3.240
Authors: Jennifer Straatman; Miguel A Cuesta; Jurriaan B Tuynman; Alexander A F A Veenhof; Willem A Bemelman; Donald L van der Peet Journal: Surg Endosc Date: 2017-12-27 Impact factor: 4.584
Authors: Mateusz Wierdak; Magdalena Pisarska; Beata Kuśnierz-Cabala; Michał Kisielewski; Piotr Major; Jan S Witowski; Piotr Ceranowicz; Marcin Strzałka; Andrzej Budzyński; Michał Pędziwiatr Journal: Wideochir Inne Tech Maloinwazyjne Date: 2018-05-16 Impact factor: 1.195