Literature DB >> 24837194

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression.

Reinhard Kalb1, Sebastian Latwiel2, H Irem Baymaz3, Pascal W T C Jansen4, Christoph W Müller5, Michiel Vermeulen4, Jürg Müller1.   

Abstract

A key step in gene repression by Polycomb is trimethylation of histone H3 K27 by PCR2 to form H3K27me3. H3K27me3 provides a binding surface for PRC1. We show that monoubiquitination of histone H2A by PRC1-type complexes to form H2Aub creates a binding site for Jarid2-Aebp2-containing PRC2 and promotes H3K27 trimethylation on H2Aub nucleosomes. Jarid2, Aebp2 and H2Aub thus constitute components of a positive feedback loop establishing H3K27me3 chromatin domains.

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Year:  2014        PMID： 24837194     DOI： 10.1038/nsmb.2833

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  23 in total

1.  PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.

Authors:  Zhonghua Gao; Jin Zhang; Roberto Bonasio; Francesco Strino; Ayana Sawai; Fabio Parisi; Yuval Kluger; Danny Reinberg
Journal:  Mol Cell       Date:  2012-02-10       Impact factor: 17.970

2.  Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.

Authors:  Sarah J Whitcomb; Beat Fierz; Robert K McGinty; Matthew Holt; Takashi Ito; Tom W Muir; C David Allis
Journal:  J Biol Chem       Date:  2012-05-22       Impact factor: 5.157

3.  Histone methylation by PRC2 is inhibited by active chromatin marks.

Authors:  Frank W Schmitges; Archana B Prusty; Mahamadou Faty; Alexandra Stützer; Gondichatnahalli M Lingaraju; Jonathan Aiwazian; Ragna Sack; Daniel Hess; Ling Li; Shaolian Zhou; Richard D Bunker; Urs Wirth; Tewis Bouwmeester; Andreas Bauer; Nga Ly-Hartig; Kehao Zhao; Homan Chan; Justin Gu; Heinz Gut; Wolfgang Fischle; Jürg Müller; Nicolas H Thomä
Journal:  Mol Cell       Date:  2011-05-06       Impact factor: 17.970

4.  PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming.

Authors:  Zhuo Zhang; Amanda Jones; Chiao-Wang Sun; Chao Li; Chia-Wei Chang; Heui-Yun Joo; Qian Dai; Matthew R Mysliwiec; Li-Chen Wu; Yahong Guo; Wei Yang; Kaimao Liu; Kevin M Pawlik; Hediye Erdjument-Bromage; Paul Tempst; Youngsook Lee; Jinrong Min; Tim M Townes; Hengbin Wang
Journal:  Stem Cells       Date:  2011-02       Impact factor: 6.277

5.  A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb.

Authors:  Ana Raquel Pengelly; Ömer Copur; Herbert Jäckle; Alf Herzig; Jürg Müller
Journal:  Science       Date:  2013-02-08       Impact factor: 47.728

6.  A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities.

Authors:  Tetyana Klymenko; Bernadett Papp; Wolfgang Fischle; Thomas Köcher; Malgorzata Schelder; Cornelia Fritsch; Brigitte Wild; Matthias Wilm; Jürg Müller
Journal:  Genes Dev       Date:  2006-04-17       Impact factor: 11.361

Review 7.  Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put.

Authors:  Jeffrey A Simon; Robert E Kingston
Journal:  Mol Cell       Date:  2013-03-07       Impact factor: 17.970

8.  SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

Authors:  Ru Cao; Yi Zhang
Journal:  Mol Cell       Date:  2004-07-02       Impact factor: 17.970

Review 9.  The Polycomb complex PRC2 and its mark in life.

Authors:  Raphaël Margueron; Danny Reinberg
Journal:  Nature       Date:  2011-01-20       Impact factor: 49.962

10.  The role of the histone H2A ubiquitinase Sce in Polycomb repression.

Authors:  Luis Gutiérrez; Katarzyna Oktaba; Johanna C Scheuermann; Maria Cristina Gambetta; Nga Ly-Hartig; Jürg Müller
Journal:  Development       Date:  2011-11-17       Impact factor: 6.868
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  199 in total

Review 1.  Aberrant histone modifications induced by mutant ASXL1 in myeloid neoplasms.

Authors:  Shuhei Asada; Toshio Kitamura
Journal:  Int J Hematol       Date:  2018-12-05       Impact factor: 2.490

2.  Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation.

Authors:  Roubina Tatavosian; Samantha Kent; Kyle Brown; Tingting Yao; Huy Nguyen Duc; Thao Ngoc Huynh; Chao Yu Zhen; Brian Ma; Haobin Wang; Xiaojun Ren
Journal:  J Biol Chem       Date:  2018-12-04       Impact factor: 5.157

Review 3.  Polycomb and Trithorax Group Genes in Drosophila.

Authors:  Judith A Kassis; James A Kennison; John W Tamkun
Journal:  Genetics       Date:  2017-08       Impact factor: 4.562

Review 4.  Touch, act and go: landing and operating on nucleosomes.

Authors:  Valentina Speranzini; Simona Pilotto; Titia K Sixma; Andrea Mattevi
Journal:  EMBO J       Date:  2016-01-19       Impact factor: 11.598

5.  The Polycomb-Group Repressor MEDEA Attenuates Pathogen Defense.

Authors:  Shweta Roy; Priya Gupta; Mohit Pradip Rajabhoj; Ravi Maruthachalam; Ashis Kumar Nandi
Journal:  Plant Physiol       Date:  2018-06-28       Impact factor: 8.340

6.  BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase.

Authors:  Asad M Taherbhoy; Oscar W Huang; Andrea G Cochran
Journal:  Nat Commun       Date:  2015-07-07       Impact factor: 14.919

7.  Systematic discovery of Xist RNA binding proteins.

Authors:  Ci Chu; Qiangfeng Cliff Zhang; Simão Teixeira da Rocha; Ryan A Flynn; Maheetha Bharadwaj; J Mauro Calabrese; Terry Magnuson; Edith Heard; Howard Y Chang
Journal:  Cell       Date:  2015-04-02       Impact factor: 41.582

8.  Brief Communication: Featured Article: Histone H2A mono-ubiquitination and cellular transformation are inversely related in N-nitrosodiethylamine-induced hepatocellular carcinoma.

Authors:  Saikat Bhattacharya; Divya Reddy; Arvind Ingle; Bharat Khade; Sanjay Gupta
Journal:  Exp Biol Med (Maywood)       Date:  2016-05-06

Review 9.  H3K27 methylation: a promiscuous repressive chromatin mark.

Authors:  Elizabeth T Wiles; Eric U Selker
Journal:  Curr Opin Genet Dev       Date:  2016-12-08       Impact factor: 5.578

10.  Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation.

Authors:  Shu Meng; Gang Zhou; Qilin Gu; Palas K Chanda; Frank Ospino; John P Cooke
Journal:  Circ Res       Date:  2016-09-13       Impact factor: 17.367
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