Literature DB >> 27190257

Brief Communication: Featured Article: Histone H2A mono-ubiquitination and cellular transformation are inversely related in N-nitrosodiethylamine-induced hepatocellular carcinoma.

Saikat Bhattacharya1, Divya Reddy1, Arvind Ingle2, Bharat Khade1, Sanjay Gupta3.   

Abstract

Aberrant changes in histone post-translational modifications are encountered frequently in diseases like cancer. Although histone H3 post-translational modifications have been extensively studied in context of diseases, the functionally important histone H2A PTM H2A119ub (H2Aub) has not gained much attention. In this study, we report that H2Aub markedly decreases in hepatocellular carcinoma. Usp21, a H2A deubiquitinase, is probably responsible for decrease in H2Aub. In addition, the H2Aub levels showed an inverse correlation with H3S10 phosphorylation (H3S10p) and the proliferative state of the cells. Downregulation of H2Aub is also associated with increased expression of growth factor gene lipocalin 2. Interestingly, we show that treatment of cells with histone deacetylase inhibitor trichostatin A results in increase of H2Aub and decrease in H3S10p. Our work for the first time suggests the in vivo association of H3S10p, H4ac, and H2A119ub with cellular transformation.
© 2016 by the Society for Experimental Biology and Medicine.

Entities:  

Keywords:  Histone post-translational modifications; cancer; deubiquitination; epigenetics; histone deacetylase inhibitor; lipocalin 2

Mesh：

Substances：

Year:  2016        PMID： 27190257      PMCID： PMC5027941          DOI： 10.1177/1535370216649262

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  16 in total

1.  A novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity.

Authors:  Yun Li; Gary D Kao; Benjamin A Garcia; Jeffrey Shabanowitz; Donald F Hunt; Jun Qin; Caroline Phelan; Mitchell A Lazar
Journal:  Genes Dev       Date:  2006-09-15       Impact factor: 11.361

Review 2.  Regulation of chromatin by histone modifications.

Authors:  Andrew J Bannister; Tony Kouzarides
Journal:  Cell Res       Date:  2011-02-15       Impact factor: 25.617

3.  Phosphorylation of histone H3 at serine 10 is indispensable for neoplastic cell transformation.

Authors:  Hong Seok Choi; Bu Young Choi; Yong-Yeon Cho; Hideya Mizuno; Bong Seok Kang; Ann M Bode; Zigang Dong
Journal:  Cancer Res       Date:  2005-07-01       Impact factor: 12.701

4.  Overexpression of histone variant H2A.1 and cellular transformation are related in N-nitrosodiethylamine-induced sequential hepatocarcinogenesis.

Authors:  Satyajeet P Khare; Ajitkumar Sharma; Kedar K Deodhar; Sanjay Gupta
Journal:  Exp Biol Med (Maywood)       Date:  2011-01

5.  Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.

Authors:  M Göttlicher; S Minucci; P Zhu; O H Krämer; A Schimpf; S Giavara; J P Sleeman; F Lo Coco; C Nervi; P G Pelicci; T Heinzel
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

6.  Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines.

Authors:  Sakura Sakajiri; Takashi Kumagai; Norihiko Kawamata; Takayuki Saitoh; Jonathan W Said; H Phillip Koeffler
Journal:  Exp Hematol       Date:  2005-01       Impact factor: 3.084

7.  Characterization of histone H2A and H2B variants and their post-translational modifications by mass spectrometry.

Authors:  Débora Bonenfant; Michèle Coulot; Harry Towbin; Patrick Schindler; Jan van Oostrum
Journal:  Mol Cell Proteomics       Date:  2005-11-30       Impact factor: 5.911

8.  Lipocalin 2 promotes breast cancer progression.

Authors:  Jiang Yang; Diane R Bielenberg; Scott J Rodig; Robert Doiron; Matthew C Clifton; Andrew L Kung; Roland K Strong; David Zurakowski; Marsha A Moses
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-23       Impact factor: 11.205

9.  Disappearance of a structural chromatin protein A24 in mitosis: implications for molecular basis of chromatin condensation.

Authors:  S I Matsui; B K Seon; A A Sandberg
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

10.  Regulation of cell cycle progression and gene expression by H2A deubiquitination.

Authors:  Heui-Yun Joo; Ling Zhai; Chunying Yang; Shuyi Nie; Hediye Erdjument-Bromage; Paul Tempst; Chenbei Chang; Hengbin Wang
Journal:  Nature       Date:  2007-10-03       Impact factor: 49.962
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  4 in total

Review 1.  New Insights into the Epigenetics of Hepatocellular Carcinoma.

Authors:  Braira Wahid; Amjad Ali; Shazia Rafique; Muhammad Idrees
Journal:  Biomed Res Int       Date:  2017-03-19       Impact factor: 3.411

2.  A twenty gene-based gene set variation score reflects the pathological progression from cirrhosis to hepatocellular carcinoma.

Authors:  Yan Lin; Rong Liang; Jiazhou Ye; Qian Li; Ziyu Liu; Xing Gao; Xuemin Piao; Rongyun Mai; Donghua Zou; Lianying Ge
Journal:  Aging (Albany NY)       Date:  2019-12-06       Impact factor: 5.682

Review 3.  Hepigenetics: A Review of Epigenetic Modulators and Potential Therapies in Hepatocellular Carcinoma.

Authors:  Mohamed H Yousef; Hassan A N El-Fawal; Anwar Abdelnaser
Journal:  Biomed Res Int       Date:  2020-11-24       Impact factor: 3.411

Review 4.  Insights Into the Properties, Biological Functions, and Regulation of USP21.

Authors:  Tao An; Yanting Lu; Xu Yan; Jingjing Hou
Journal:  Front Pharmacol       Date:  2022-06-30       Impact factor: 5.988
  4 in total

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