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Literature DB >> 24823649

Reading RNA methylation codes through methyl-specific binding proteins.

Abstract

N (6)-methyladenosine (m (6)A) is a prevalent modification of eukaryotic mRNAs. It regulates yeast cell fate and is essential to the development and fertility of metazoans. Although its presence in mRNA has been known since the early 1970s, the function of m (6)A remained a mystery until the spate of discoveries in the past three years. Here, we focus on the discovery of m (6)A "readers" (proteins that specifically recognize m (6)A), and their functions in tuning mRNA stability, as well as the broader significance of such m (6)A-dependent regulation of gene expression.

Entities: Chemical Species

Keywords: N6-methyladenosine; RNA methylation; RNA stability; RNA-binding protein; YTH domain; YTHDF2; gene expression regulation; m6A; reversible RNA modification

Mesh：

Substances：

Year: 2014 PMID： 24823649 PMCID： PMC4156498 DOI： 10.4161/rna.28829

Source DB: PubMed Journal: RNA Biol ISSN： 1547-6286 Impact factor: 4.652

28 in total

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Authors: Adrian Bird
Journal: Genes Dev Date: 2002-01-01 Impact factor: 11.361

2. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies.

Authors: Ujwal Sheth; Roy Parker
Journal: Science Date: 2003-05-02 Impact factor: 47.728

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Journal: Int J Biochem Date: 1992-03

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Authors: Mary J Clancy; Mary Eileen Shambaugh; Candace S Timpte; Joseph A Bokar
Journal: Nucleic Acids Res Date: 2002-10-15 Impact factor: 16.971

6. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase.

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Journal: RNA Date: 1997-11 Impact factor: 4.942

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Journal: Mol Cell Biol Date: 1992-03 Impact factor: 4.272

8. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor.

Authors: Silin Zhong; Hongying Li; Zsuzsanna Bodi; James Button; Laurent Vespa; Michel Herzog; Rupert G Fray
Journal: Plant Cell Date: 2008-05-27 Impact factor: 11.277

9. Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid.

Authors: C M Wei; B Moss
Journal: Biochemistry Date: 1977-04-19 Impact factor: 3.162

10. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.

Authors: Jianzhao Liu; Yanan Yue; Dali Han; Xiao Wang; Ye Fu; Liang Zhang; Guifang Jia; Miao Yu; Zhike Lu; Xin Deng; Qing Dai; Weizhong Chen; Chuan He
Journal: Nat Chem Biol Date: 2013-12-06 Impact factor: 15.040

55 in total

1. N(6)-methyladenosine Modulates Messenger RNA Translation Efficiency.

Authors: Xiao Wang; Boxuan Simen Zhao; Ian A Roundtree; Zhike Lu; Dali Han; Honghui Ma; Xiaocheng Weng; Kai Chen; Hailing Shi; Chuan He
Journal: Cell Date: 2015-06-04 Impact factor: 41.582

2. A Unified Model for the Function of YTHDF Proteins in Regulating m⁶A-Modified mRNA.

Authors: Sara Zaccara; Samie R Jaffrey
Journal: Cell Date: 2020-06-02 Impact factor: 41.582

Review 3. Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system.

Authors: Kun Zhao; Chuan-Xi Yang; Peng Li; Wei Sun; Xiang-Qing Kong
Journal: J Zhejiang Univ Sci B Date: 2020-07 Impact factor: 3.066

4. ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.

Authors: Chong Tang; Rachel Klukovich; Hongying Peng; Zhuqing Wang; Tian Yu; Ying Zhang; Huili Zheng; Arne Klungland; Wei Yan
Journal: Proc Natl Acad Sci U S A Date: 2017-12-26 Impact factor: 11.205

Review 5. The Clothes Make the mRNA: Past and Present Trends in mRNP Fashion.

Authors: Guramrit Singh; Gabriel Pratt; Gene W Yeo; Melissa J Moore
Journal: Annu Rev Biochem Date: 2015-03-11 Impact factor: 23.643

6. Selective termination of lncRNA transcription promotes heterochromatin silencing and cell differentiation.

Authors: Leila Touat-Todeschini; Yuichi Shichino; Mathieu Dangin; Nicolas Thierry-Mieg; Benoit Gilquin; Edwige Hiriart; Ravi Sachidanandam; Emeline Lambert; Janine Brettschneider; Michael Reuter; Jan Kadlec; Ramesh Pillai; Akira Yamashita; Masayuki Yamamoto; André Verdel
Journal: EMBO J Date: 2017-08-01 Impact factor: 11.598