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Literature DB >> 24792186

Unresolved questions from the analysis of mice lacking MCU expression.

Elizabeth Murphy¹, Xin Pan², Tiffany Nguyen³, Jie Liu², Kira M Holmström², Toren Finkel⁴.

Abstract

Entry of mitochondrial calcium is believed to play an essential role in regulating bioenergetics and initiating cell death pathways. We have recently described a mouse model lacking MCU expression. Surprisingly, these mice are viable and the cells and tissues from these animals do not exhibit any marked protection from cell death. Here, we discuss our findings as well as potential explanations for some of the more unexpected results. Published by Elsevier Inc.

Entities: CellLine Chemical Disease Gene Species

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Year: 2014 PMID： 24792186 PMCID： PMC4214067 DOI： 10.1016/j.bbrc.2014.04.144

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

13 in total

Review 1. Calcium-mediated cell death during myocardial reperfusion.

Authors: David Garcia-Dorado; Marisol Ruiz-Meana; Javier Inserte; Antonio Rodriguez-Sinovas; Hans Michael Piper
Journal: Cardiovasc Res Date: 2012-04-11 Impact factor: 10.787

2. Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion.

Authors: Jae-Sung Kim; Yingai Jin; John J Lemasters
Journal: Am J Physiol Heart Circ Physiol Date: 2006-01-06 Impact factor: 4.733

3. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.

Authors: Christopher P Baines; Robert A Kaiser; Nicole H Purcell; N Scott Blair; Hanna Osinska; Michael A Hambleton; Eric W Brunskill; M Richard Sayen; Roberta A Gottlieb; Gerald W Dorn; Jeffrey Robbins; Jeffery D Molkentin
Journal: Nature Date: 2005-03-31 Impact factor: 49.962

4. Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo.

Authors: G de J García-Rivas; K Carvajal; F Correa; C Zazueta
Journal: Br J Pharmacol Date: 2006-10-09 Impact factor: 8.739

5. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Authors: M M Shull; I Ormsby; A B Kier; S Pawlowski; R J Diebold; M Yin; R Allen; C Sidman; G Proetzel; D Calvin
Journal: Nature Date: 1992-10-22 Impact factor: 49.962

6. The identity and regulation of the mitochondrial permeability transition pore: where the known meets the unknown.

Authors: Magdalena Juhaszova; Su Wang; Dmitry B Zorov; H Bradley Nuss; Marc Gleichmann; Mark P Mattson; Steven J Sollott
Journal: Ann N Y Acad Sci Date: 2008-03 Impact factor: 5.691

7. Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.

Authors: S Yu; D Yu; E Lee; M Eckhaus; R Lee; Z Corria; D Accili; H Westphal; L S Weinstein
Journal: Proc Natl Acad Sci U S A Date: 1998-07-21 Impact factor: 11.205

8. CaMKII determines mitochondrial stress responses in heart.

Authors: Mei-Ling A Joiner; Olha M Koval; Jingdong Li; B Julie He; Chantal Allamargot; Zhan Gao; Elizabeth D Luczak; Duane D Hall; Brian D Fink; Biyi Chen; Jinying Yang; Steven A Moore; Thomas D Scholz; Stefan Strack; Peter J Mohler; William I Sivitz; Long-Sheng Song; Mark E Anderson
Journal: Nature Date: 2012-10-10 Impact factor: 49.962

9. Loss of Roquin induces early death and immune deregulation but not autoimmunity.

Authors: Arianna Bertossi; Martin Aichinger; Paola Sansonetti; Maciej Lech; Frauke Neff; Martin Pal; F Thomas Wunderlich; Hans-Joachim Anders; Ludger Klein; Marc Schmidt-Supprian
Journal: J Exp Med Date: 2011-08-15 Impact factor: 14.307

10. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

Authors: Xin Pan; Jie Liu; Tiffany Nguyen; Chengyu Liu; Junhui Sun; Yanjie Teng; Maria M Fergusson; Ilsa I Rovira; Michele Allen; Danielle A Springer; Angel M Aponte; Marjan Gucek; Robert S Balaban; Elizabeth Murphy; Toren Finkel
Journal: Nat Cell Biol Date: 2013-11-10 Impact factor: 28.824

55 in total

Review 1. The molecular era of the mitochondrial calcium uniporter.

Authors: Kimberli J Kamer; Vamsi K Mootha
Journal: Nat Rev Mol Cell Biol Date: 2015-08-19 Impact factor: 94.444

Review 2. Why don't mice lacking the mitochondrial Ca²⁺ uniporter experience an energy crisis?

Authors: Pei Wang; Celia Fernandez-Sanz; Wang Wang; Shey-Shing Sheu
Journal: J Physiol Date: 2018-10-11 Impact factor: 5.182

Review 3. The Mitochondrial Ca²⁺ Uniporter: Structure, Function, and Pharmacology.

Authors: Jyotsna Mishra; Bong Sook Jhun; Stephen Hurst; Jin O-Uchi; György Csordás; Shey-Shing Sheu
Journal: Handb Exp Pharmacol Date: 2017

4. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

Authors: Tyler P Rasmussen; Yuejin Wu; Mei-ling A Joiner; Olha M Koval; Nicholas R Wilson; Elizabeth D Luczak; Qinchuan Wang; Biyi Chen; Zhan Gao; Zhiyong Zhu; Brett A Wagner; Jamie Soto; Michael L McCormick; William Kutschke; Robert M Weiss; Liping Yu; Ryan L Boudreau; E Dale Abel; Fenghuang Zhan; Douglas R Spitz; Garry R Buettner; Long-Sheng Song; Leonid V Zingman; Mark E Anderson
Journal: Proc Natl Acad Sci U S A Date: 2015-07-07 Impact factor: 11.205

5. The mitochondrial Na⁺/Ca²⁺ exchanger is essential for Ca²⁺ homeostasis and viability.

Authors: Timothy S Luongo; Jonathan P Lambert; Polina Gross; Mary Nwokedi; Alyssa A Lombardi; Santhanam Shanmughapriya; April C Carpenter; Devin Kolmetzky; Erhe Gao; Jop H van Berlo; Emily J Tsai; Jeffery D Molkentin; Xiongwen Chen; Muniswamy Madesh; Steven R Houser; John W Elrod
Journal: Nature Date: 2017-04-26 Impact factor: 49.962

6. EMRE is essential for mitochondrial calcium uniporter activity in a mouse model.

Authors: Julia C Liu; Nicole C Syder; Nima S Ghorashi; Thomas B Willingham; Randi J Parks; Junhui Sun; Maria M Fergusson; Jie Liu; Kira M Holmström; Sara Menazza; Danielle A Springer; Chengyu Liu; Brian Glancy; Toren Finkel; Elizabeth Murphy
Journal: JCI Insight Date: 2020-02-27

7. Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death.

Authors: Sekyu Choi; Xianglan Quan; Sunhoe Bang; Heesuk Yoo; Jiyoung Kim; Jiwon Park; Kyu-Sang Park; Jongkyeong Chung
Journal: J Biol Chem Date: 2017-07-18 Impact factor: 5.157

Unresolved questions from the analysis of mice lacking MCU expression.

Review 1. Calcium-mediated cell death during myocardial reperfusion.

2. Reactive oxygen species, but not Ca2+ overloading, trigger pH- and mitochondrial permeability transition-dependent death of adult rat myocytes after ischemia-reperfusion.

3. Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death.

4. Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo.

5. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

6. The identity and regulation of the mitochondrial permeability transition pore: where the known meets the unknown.

7. Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene.

8. CaMKII determines mitochondrial stress responses in heart.

9. Loss of Roquin induces early death and immune deregulation but not autoimmunity.

10. The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.

Review 1. The molecular era of the mitochondrial calcium uniporter.

Review 2. Why don't mice lacking the mitochondrial Ca²⁺ uniporter experience an energy crisis?

Review 3. The Mitochondrial Ca²⁺ Uniporter: Structure, Function, and Pharmacology.

4. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.

5. The mitochondrial Na⁺/Ca²⁺ exchanger is essential for Ca²⁺ homeostasis and viability.

6. EMRE is essential for mitochondrial calcium uniporter activity in a mouse model.

7. Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death.

Review 8. Regulation of Mitochondrial ATP Production: Ca²⁺ Signaling and Quality Control.

Review 9. Mitochondrial Ca²⁺ uptake pathways.

10. Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila.

Review 1. Calcium-mediated cell death during myocardial reperfusion.

Review 1. The molecular era of the mitochondrial calcium uniporter.

Review 2. Why don't mice lacking the mitochondrial Ca2+ uniporter experience an energy crisis?

Review 3. The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.

Review 8. Regulation of Mitochondrial ATP Production: Ca2+ Signaling and Quality Control.

Review 9. Mitochondrial Ca2+ uptake pathways.

Review 2. Why don't mice lacking the mitochondrial Ca²⁺ uniporter experience an energy crisis?

Review 3. The Mitochondrial Ca²⁺ Uniporter: Structure, Function, and Pharmacology.

Review 8. Regulation of Mitochondrial ATP Production: Ca²⁺ Signaling and Quality Control.

Review 9. Mitochondrial Ca²⁺ uptake pathways.