Literature DB >> 28194521

The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.

Jyotsna Mishra1, Bong Sook Jhun2, Stephen Hurst1, Jin O-Uchi3, György Csordás4, Shey-Shing Sheu5.   

Abstract

Mitochondrial Ca2+ uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca2+ uptake and our current understanding of mitochondrial Ca2+ homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca2+ uniporter complex.

Entities:  

Keywords:  Mitochondria; Mitochondrial Ca2+ uniporter; Mitochondrial Ca2+ uptake; Pharmacology

Mesh：

Substances：

Year:  2017        PMID： 28194521      PMCID： PMC5554456          DOI： 10.1007/164_2017_1

Source DB:  PubMed          Journal:  Handb Exp Pharmacol        ISSN： 0171-2004


  170 in total

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