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Literature DB >> 26285678

The molecular era of the mitochondrial calcium uniporter.

Kimberli J Kamer^1,2, Vamsi K Mootha^2,3,4.

Abstract

The mitochondrial calcium uniporter is an evolutionarily conserved calcium channel, and its biophysical properties and relevance to cell death, bioenergetics and signalling have been investigated for decades. However, the genes encoding this channel have only recently been discovered, opening up a new 'molecular era' in the study of its biology. We now know that the uniporter is not a single protein but rather a macromolecular complex consisting of pore-forming and regulatory subunits. We review recent studies that harnessed the power of molecular biology and genetics to characterize the mechanism of action of the uniporter, its evolution and its contribution to physiology and human disease.

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Year: 2015 PMID： 26285678 DOI： 10.1038/nrm4039

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

71 in total

1. Calcium--a life and death signal.

Authors: M J Berridge; M D Bootman; P Lipp
Journal: Nature Date: 1998-10-15 Impact factor: 49.962

2. Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes.

Authors: Ilaria Drago; Diego De Stefani; Rosario Rizzuto; Tullio Pozzan
Journal: Proc Natl Acad Sci U S A Date: 2012-07-20 Impact factor: 11.205

3. A mitochondrial protein compendium elucidates complex I disease biology.

Authors: David J Pagliarini; Sarah E Calvo; Betty Chang; Sunil A Sheth; Scott B Vafai; Shao-En Ong; Geoffrey A Walford; Canny Sugiana; Avihu Boneh; William K Chen; David E Hill; Marc Vidal; James G Evans; David R Thorburn; Steven A Carr; Vamsi K Mootha
Journal: Cell Date: 2008-07-11 Impact factor: 41.582

4. Ca2+ transport by coupled Trypanosoma cruzi mitochondria in situ.

Authors: R Docampo; A E Vercesi
Journal: J Biol Chem Date: 1989-01-05 Impact factor: 5.157

Review 5. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.

Authors: Thomas Gaj; Charles A Gersbach; Carlos F Barbas
Journal: Trends Biotechnol Date: 2013-05-09 Impact factor: 19.536

6. Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish.

Authors: Julien Prudent; Nikolay Popgeorgiev; Benjamin Bonneau; Julien Thibaut; Rudy Gadet; Jonathan Lopez; Philippe Gonzalo; Ruth Rimokh; Stephen Manon; Corinne Houart; Philippe Herbomel; Abdel Aouacheria; Germain Gillet
Journal: Nat Commun Date: 2013 Impact factor: 14.919

7. Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes.

Authors: L S Jouaville; F Ichas; E L Holmuhamedov; P Camacho; J D Lechleiter
Journal: Nature Date: 1995-10-05 Impact factor: 49.962

8. Block by ruthenium red of the ryanodine-activated calcium release channel of skeletal muscle.

Authors: J Ma
Journal: J Gen Physiol Date: 1993-12 Impact factor: 4.086

9. SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

Authors: Nicholas E Hoffman; Harish C Chandramoorthy; Santhanam Shanmughapriya; Xueqian Q Zhang; Sandhya Vallem; Patrick J Doonan; Karthik Malliankaraman; Shuchi Guo; Sudarsan Rajan; John W Elrod; Walter J Koch; Joseph Y Cheung; Muniswamy Madesh
Journal: Mol Biol Cell Date: 2014-01-15 Impact factor: 4.138

10. Mitochondrial calcium uniporter MCU supports cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry and Ca2+-dependent gene expression in response to receptor stimulation.

Authors: Krishna Samanta; Sophie Douglas; Anant B Parekh
Journal: PLoS One Date: 2014-07-08 Impact factor: 3.240

132 in total

1. Mitochondrial Ca²⁺ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.

Authors: Zhiwei Dong; Santhanam Shanmughapriya; Dhanendra Tomar; Naveed Siddiqui; Solomon Lynch; Neeharika Nemani; Sarah L Breves; Xueqian Zhang; Aparna Tripathi; Palaniappan Palaniappan; Massimo F Riitano; Alison M Worth; Ajay Seelam; Edmund Carvalho; Ramasamy Subbiah; Fabián Jaña; Jonathan Soboloff; Yizhi Peng; Joseph Y Cheung; Suresh K Joseph; Jeffrey Caplan; Sudarsan Rajan; Peter B Stathopulos; Muniswamy Madesh
Journal: Mol Cell Date: 2017-03-02 Impact factor: 17.970

2. Cryo-EM structure of a mitochondrial calcium uniporter.

Authors: Jiho Yoo; Mengyu Wu; Ying Yin; Mark A Herzik; Gabriel C Lander; Seok-Yong Lee
Journal: Science Date: 2018-06-28 Impact factor: 47.728

Review 3. Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome: Hemizygous deletion of several mitochondrial genes in the 22q11.2 genomic region can lead to symptoms associated with neuropsychiatric disease.

Authors: Prakash Devaraju; Stanislav S Zakharenko
Journal: Bioessays Date: 2017-01-03 Impact factor: 4.345

4. The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.

Authors: Ngang Heok Tang; Kyung Won Kim; Suhong Xu; Stephen M Blazie; Brian A Yee; Gene W Yeo; Yishi Jin; Andrew D Chisholm
Journal: Curr Biol Date: 2020-01-23 Impact factor: 10.834

5. Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism.

Authors: Kimberli J Kamer; Wei Jiang; Virendar K Kaushik; Vamsi K Mootha; Zenon Grabarek
Journal: Proc Natl Acad Sci U S A Date: 2019-02-12 Impact factor: 11.205

6. Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death.

Authors: Hong Z Yin; Hwai-Lee Wang; Sung G Ji; Yuliya V Medvedeva; Guilian Tian; Afsheen K Bazrafkan; Niki Z Maki; Yama Akbari; John H Weiss
Journal: J Neuropathol Exp Neurol Date: 2019-07-01 Impact factor: 3.685

The molecular era of the mitochondrial calcium uniporter.

1. Calcium--a life and death signal.

2. Mitochondrial Ca2+ uptake contributes to buffering cytoplasmic Ca2+ peaks in cardiomyocytes.

3. A mitochondrial protein compendium elucidates complex I disease biology.

4. Ca2+ transport by coupled Trypanosoma cruzi mitochondria in situ.

Review 5. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.

6. Bcl-wav and the mitochondrial calcium uniporter drive gastrula morphogenesis in zebrafish.

7. Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes.

8. Block by ruthenium red of the ryanodine-activated calcium release channel of skeletal muscle.

9. SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death.

10. Mitochondrial calcium uniporter MCU supports cytoplasmic Ca2+ oscillations, store-operated Ca2+ entry and Ca2+-dependent gene expression in response to receptor stimulation.

1. Mitochondrial Ca²⁺ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity.

2. Cryo-EM structure of a mitochondrial calcium uniporter.

Review 3. Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome: Hemizygous deletion of several mitochondrial genes in the 22q11.2 genomic region can lead to symptoms associated with neuropsychiatric disease.

4. The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.

5. Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism.

6. Rapid Intramitochondrial Zn2+ Accumulation in CA1 Hippocampal Pyramidal Neurons After Transient Global Ischemia: A Possible Contributor to Mitochondrial Disruption and Cell Death.

Review 7. Ca²⁺ as a therapeutic target in cancer.

Review 8. Mitochondrial energetics and calcium coupling in the heart.

9. Structural Insights into Mitochondrial Calcium Uniporter Regulation by Divalent Cations.

10. Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila.

Review 5. ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.

Review 3. Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome: Hemizygous deletion of several mitochondrial genes in the 22q11.2 genomic region can lead to symptoms associated with neuropsychiatric disease.

Review 7. Ca2+ as a therapeutic target in cancer.

Review 8. Mitochondrial energetics and calcium coupling in the heart.

Review 7. Ca²⁺ as a therapeutic target in cancer.