| Literature DB >> 1436033 |
M M Shull1, I Ormsby, A B Kier, S Pawlowski, R J Diebold, M Yin, R Allen, C Sidman, G Proetzel, D Calvin.
Abstract
Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.Entities:
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Year: 1992 PMID： 1436033 PMCID： PMC3889166 DOI： 10.1038/359693a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962