Literature DB >> 2476574

Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype.

R P Roos1, S Stein, M Routbort, A Senkowski, T Bodwell, R Wollmann.   

Abstract

DA strain of Theiler's murine encephalomyelitis virus produces a persistent demyelinating infection. We previously produced escape mutant viruses that are resistant to a neutralizing monoclonal antibody and have a mutation in VP1 amino acid residue 268 in a neutralization site (Y. Ohara, A. Senkowski, J. Fu, L. Klaman, J. Goodall, M. Toth, and R.P. Roos, J. Virol. 62:3527-3529, 1988). In contrast to wild-type DA strain, these escape mutants produce little if any demyelinating disease after inoculation into weanling mice.

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Year:  1989        PMID： 2476574      PMCID： PMC251072     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  13 in total

Review 1.  Viral infectious complementary-DNA studies may identify nonviral genes critical to central nervous system disease.

Authors:  Y Ohara; R P Roos
Journal:  Ann Neurol       Date:  1989-03       Impact factor: 10.422

Review 2.  The antibody response in Theiler's virus infection: new perspectives on multiple sclerosis.

Authors:  Y Ohara; R Roos
Journal:  Prog Med Virol       Date:  1987

3.  Trypsin-sensitive neutralization site on VP1 of Theiler's murine encephalomyelitis viruses.

Authors:  Y Ohara; A Senkowski; J L Fu; L Klaman; J Goodall; M Toth; R P Roos
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

4.  Persistent Theiler's murine encephalomyelitis virus infection in mice depends on plaque size.

Authors:  H L Lipton
Journal:  J Gen Virol       Date:  1980-01       Impact factor: 3.891

5.  A neutralization-resistant Theiler's virus variant produces an altered disease pattern in the mouse central nervous system.

Authors:  A Zurbriggen; R S Fujinami
Journal:  J Virol       Date:  1989-04       Impact factor: 5.103

6.  Isolation and characterization of two plaque size variants of Theiler's murine encephalomyelitis virus (DA strain).

Authors:  E L Oleszak; J L Leibowitz; M Rodriguez
Journal:  J Gen Virol       Date:  1988-09       Impact factor: 3.891

7.  Localization of a neutralization site of Theiler's murine encephalomyelitis viruses.

Authors:  S Nitayaphan; M M Toth; R P Roos
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

8.  Theiler's murine encephalomyelitis virus group includes two distinct genetic subgroups that differ pathologically and biologically.

Authors:  Y Lorch; A Friedmann; H L Lipton; M Kotler
Journal:  J Virol       Date:  1981-11       Impact factor: 5.103

9.  Poliovirus host range is determined by a short amino acid sequence in neutralization antigenic site I.

Authors:  M G Murray; J Bradley; X F Yang; E Wimmer; E G Moss; V R Racaniello
Journal:  Science       Date:  1988-07-08       Impact factor: 47.728

10.  Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice.

Authors:  A Martin; C Wychowski; T Couderc; R Crainic; J Hogle; M Girard
Journal:  EMBO J       Date:  1988-09       Impact factor: 11.598
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  25 in total

1.  Determinants of persistence and demyelination of the DA strain of Theiler's virus are found only in the VP1 gene.

Authors:  F Tangy; A McAllister; C Aubert; M Brahic
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

2.  A single amino acid change determines persistence of a chimeric Theiler's virus.

Authors:  N Jarousse; R A Grant; J M Hogle; L Zhang; A Senkowski; R P Roos; T Michiels; M Brahic; A McAllister
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103

3.  Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA viruses.

Authors:  M Rodriguez; R P Roos
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

4.  Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome.

Authors:  A Ramsingh; A Hixson; B Duceman; J Slack
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

5.  Hemagglutinin mutations related to attenuation and altered cell tropism of a virulent avian influenza A virus.

Authors:  M Philpott; C Hioe; M Sheerar; V S Hinshaw
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

6.  Role of VP2 amino acid 141 in tropism of Theiler's virus within the central nervous system.

Authors:  N Jarousse; C Martinat; S Syan; M Brahic; A McAllister
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

7.  Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.

Authors:  R P Roos; S Stein; Y Ohara; J L Fu; B L Semler
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

8.  Three-dimensional structure of Theiler virus.

Authors:  R A Grant; D J Filman; R S Fujinami; J P Icenogle; J M Hogle
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

9.  Mutations that affect the tropism of DA and GDVII strains of Theiler's virus in vitro influence sialic acid binding and pathogenicity.

Authors:  Karima Jnaoui; Muriel Minet; Thomas Michiels
Journal:  J Virol       Date:  2002-08       Impact factor: 5.103

10.  Prolonged replication in the mouse central nervous system of reoviruses isolated from persistently infected cell cultures.

Authors:  L A Morrison; B N Fields; T S Dermody
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103
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