Literature DB >> 2457118

Trypsin-sensitive neutralization site on VP1 of Theiler's murine encephalomyelitis viruses.

Y Ohara1, A Senkowski, J L Fu, L Klaman, J Goodall, M Toth, R P Roos.   

Abstract

We generated Theiler's murine encephalomyelitis virus mutants resistant to several neutralizing monoclonal antibodies (MAbs) having their epitopes near a trypsin cleavage site of VP1. Neutralization and Western blot (immunoblot) studies suggest that two of the MAbs have identical epitopes that partly overlap the epitope of a third MAb. Sequencing of RNA of the mutants localized the epitopes to a site near the carboxyl end of VP1. The limited diversity of nucleotide changes seen in the mutants and the immunodominance of the site suggest that the carboxyl end of VP1 may have an important function.

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Year:  1988        PMID： 2457118      PMCID： PMC253483     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  9 in total

1.  Relationship of Theiler's murine encephalomyelitis viruses to the cardiovirus genus of picornaviruses.

Authors:  S Nitayaphan; D Omilianowski; M M Toth; G D Parks; R R Rueckert; A C Palmenberg; R P Roos
Journal:  Intervirology       Date:  1986       Impact factor: 1.763

2.  Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses.

Authors:  D C Pevear; M Calenoff; E Rozhon; H L Lipton
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

3.  Neutralizing monoclonal antibodies to Theiler's murine encephalomyelitis viruses.

Authors:  S Nitayaphan; M M Toth; R P Roos
Journal:  J Virol       Date:  1985-02       Impact factor: 5.103

4.  Persistent Theiler's murine encephalomyelitis virus infection in mice depends on plaque size.

Authors:  H L Lipton
Journal:  J Gen Virol       Date:  1980-01       Impact factor: 3.891

5.  Localization of a neutralization site of Theiler's murine encephalomyelitis viruses.

Authors:  S Nitayaphan; M M Toth; R P Roos
Journal:  J Virol       Date:  1985-12       Impact factor: 5.103

6.  Critical role of an eight-amino acid sequence of VP1 in neutralization of poliovirus type 3.

Authors:  D M Evans; P D Minor; G S Schild; J W Almond
Journal:  Nature       Date:  1983 Aug 4-10       Impact factor: 49.962

7.  Theiler's murine encephalomyelitis virus group includes two distinct genetic subgroups that differ pathologically and biologically.

Authors:  Y Lorch; A Friedmann; H L Lipton; M Kotler
Journal:  J Virol       Date:  1981-11       Impact factor: 5.103

8.  Molecular cloning and sequence determination of DA strain of Theiler's murine encephalomyelitis viruses.

Authors:  Y Ohara; S Stein; J L Fu; L Stillman; L Klaman; R P Roos
Journal:  Virology       Date:  1988-05       Impact factor: 3.616

9.  Mutations affecting conformation or sequence of neutralizing epitopes identified by reactivity of viable plaques segregate from syn and ts domains of HSV-1(F) gB gene.

Authors:  K G Kousoulas; P E Pellett; L Pereira; B Roizman
Journal:  Virology       Date:  1984-06       Impact factor: 3.616
  9 in total
  13 in total

1.  Cytotropism of Theiler's murine encephalomyelitis viruses in oligodendrocyte-enriched cultures.

Authors:  Y Ohara; H Konno; Y Iwasaki; T Yamamoto; H Terunuma; H Suzuki
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

2.  Pathogenesis of early and late disease in mice infected with Theiler's virus, using intratypic recombinant GDVII/DA viruses.

Authors:  M Rodriguez; R P Roos
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

3.  Role of VP2 amino acid 141 in tropism of Theiler's virus within the central nervous system.

Authors:  N Jarousse; C Martinat; S Syan; M Brahic; A McAllister
Journal:  J Virol       Date:  1996-11       Impact factor: 5.103

4.  Strains from both Theiler's virus subgroups encode a determinant for demyelination.

Authors:  J Fu; M Rodriguez; R P Roos
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

5.  Theiler's murine encephalomyelitis virus neutralization escape mutants have a change in disease phenotype.

Authors:  R P Roos; S Stein; M Routbort; A Senkowski; T Bodwell; R Wollmann
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

6.  Major linear antibody epitopes and capsid proteins differentially induce protective immunity against Theiler's virus-induced demyelinating disease.

Authors:  H Yahikozawa; A Inoue; C S Koh; Y K Choe; B S Kim
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

7.  Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.

Authors:  R P Roos; S Stein; Y Ohara; J L Fu; B L Semler
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

8.  Lymphocyte recognition elements on the VP1 protein of Theiler's virus.

Authors:  E J Usherwood; I C Johnston; L J Lovelidge; P Tonks; A A Nash
Journal:  Immunology       Date:  1995-06       Impact factor: 7.397

Review 9.  Neuropathogenesis of Theiler's murine encephalomyelitis virus infection, an animal model for multiple sclerosis.

Authors:  Ikuo Tsunoda; Robert S Fujinami
Journal:  J Neuroimmune Pharmacol       Date:  2009-11-06       Impact factor: 4.147

10.  Analysis of antibody responses to predominant linear epitopes of Theiler's murine encephalomyelitis virus.

Authors:  A Inoue; Y K Choe; B S Kim
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103
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