Literature DB >> 2474830

Immunogenicity of peptide fusions to hepatitis B virus core antigen.

S J Stahl1, K Murray.   

Abstract

Several gene fusions have been constructed in which coding sequences for antigenic regions of the pre-S sequences of hepatitis B virus, hepatitis B surface antigen, and the envelope protein of human immunodeficiency virus were linked to the 3' end of that for the first 144 residues of hepatitis B core antigen. The sequences were expressed efficiently in Escherichia coli to give stable products that assembled to form particles morphologically similar to hepatitis B core antigen itself. The products exhibited the antigenic and immunogenic characteristics of both the hepatitis B core antigen epitopes and the epitopes carried by the additional sequences, thus illustrating the value of such proteins as immunological reagents and potential vaccines.

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Year:  1989        PMID： 2474830      PMCID： PMC297822          DOI： 10.1073/pnas.86.16.6283

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  39 in total

1.  Demonstration of hepatitis B e antigen (HBeAg) in association with intact Dane particles.

Authors:  H Ohori; S Onodera; N Ishida
Journal:  J Gen Virol       Date:  1979-05       Impact factor: 3.891

2.  Comparison of the nucleotide sequences of the initial transcribed regions of the tryptophan operons of Escherichia coli and Salmonella typhimurium.

Authors:  F Lee; K Bertrand; G Bennett; C Yanofsky
Journal:  J Mol Biol       Date:  1978-05-15       Impact factor: 5.469

3.  Expression in Escherichia coli of hepatitis B virus DNA sequences cloned in plasmid pBR322.

Authors:  C J Burrell; P Mackay; P J Greenaway; P H Hofschneider; K Murray
Journal:  Nature       Date:  1979-05-03       Impact factor: 49.962

4.  Alteration of hepatitis B antigen (HB Ag) determinants by reduction and alkylation.

Authors:  G R Dreesman; F B Hollinger; R M McCombs; J L Melnick
Journal:  J Gen Virol       Date:  1973-04       Impact factor: 3.891

5.  Calcium-dependent bacteriophage DNA infection.

Authors:  M Mandel; A Higa
Journal:  J Mol Biol       Date:  1970-10-14       Impact factor: 5.469

6.  Prediction of protein antigenic determinants from amino acid sequences.

Authors:  T P Hopp; K R Woods
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

7.  Production of immunologically active surface antigens of hepatitis B virus by Escherichia coli.

Authors:  P MacKay; M Pasek; M Magazin; R T Kovacic; B Allet; S Stahl; W Gilbert; H Schaller; S A Bruce; K Murray
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

8.  Expression of the hepatitis B virus surface, core and E antigen genes by stable rat and mouse cell lines.

Authors:  N M Gough; K Murray
Journal:  J Mol Biol       Date:  1982-11-25       Impact factor: 5.469

9.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

10.  Hepatitis B virus genes and their expression in E. coli.

Authors:  M Pasek; T Goto; W Gilbert; B Zink; H Schaller; P MacKay; G Leadbetter; K Murray
Journal:  Nature       Date:  1979-12-06       Impact factor: 49.962
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  34 in total

1.  The morphogenic linker peptide of HBV capsid protein forms a mobile array on the interior surface.

Authors:  Norman R Watts; James F Conway; Naiqian Cheng; Stephen J Stahl; David M Belnap; Alasdair C Steven; Paul T Wingfield
Journal:  EMBO J       Date:  2002-03-01       Impact factor: 11.598

2.  The affinities of monoclonal antibodies against core antigen of hepatitis B virus.

Authors:  U Apsalons; V Bichko
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

3.  Structural factors modulate the activity of antigenic poliovirus sequences expressed on hybrid hepatitis B surface antigen particles.

Authors:  F Delpeyroux; E Van Wezel; B Blondel; R Crainic
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

4.  Hepatitis B virus nucleocapsid assembly: primary structure requirements in the core protein.

Authors:  F Birnbaum; M Nassal
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

5.  Immunological properties of hepatitis B core antigen fusion proteins.

Authors:  M J Francis; G Z Hastings; A L Brown; K G Grace; D J Rowlands; F Brown; B E Clarke
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

6.  Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen.

Authors:  G Borisova; B Arya; A Dislers; O Borschukova; V Tsibinogin; D Skrastina; M A Eldarov; P Pumpens; K G Skryabin; E Grens
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103

7.  Immunogenicity of recombinant core particles of hepatitis B virus containing epitopes of human immunodeficiency virus 1 core antigen.

Authors:  R Ulrich; G P Borisova; E Gren; I Berzin; P Pumpen; R Eckert; V Ose; H Siakkou; E J Gren; R von Baehr
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

8.  Localization of the N terminus of hepatitis B virus capsid protein by peptide-based difference mapping from cryoelectron microscopy.

Authors:  J F Conway; N Cheng; A Zlotnick; S J Stahl; P T Wingfield; A C Steven
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205

9.  Chimeric hepatitis B virus core particles with parts or copies of the hepatitis C virus core protein.

Authors:  A Yoshikawa; T Tanaka; Y Hoshi; N Kato; K Tachibana; H Iizuka; A Machida; H Okamoto; M Yamasaki; Y Miyakawa
Journal:  J Virol       Date:  1993-10       Impact factor: 5.103

Review 10.  Use of hepadnavirus core proteins as vaccine platforms.

Authors:  David C Whitacre; Byung O Lee; David R Milich
Journal:  Expert Rev Vaccines       Date:  2009-11       Impact factor: 5.217
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