| Literature DB >> 24709918 |
Wu Hong1, Jinbo Fan, Chengmei Yuan, Chen Zhang, Yingyan Hu, Daihui Peng, Yong Wang, Jia Huang, Zezhi Li, Shunying Yu, Xiaohua Liu, Zhiguo Wu, Jun Chen, Zhenghui Yi, Lin Xu, Yiru Fang.
Abstract
The aim of the current study was to investigate whether the levels of mRNA expression of brain-derived neurotrophin factor (BDNF) and a related gene MEK1 were more obviously decreased in treatment-resistant depression (TRD). In total, 50 patients with major depressive disorder (including 26 with TRD and 24 with treatment-responsive depression) and 48 healthy controls were enrolled. BDNF and MEK1 mRNA levels in blood samples from all patients and controls were measured using reverse transcriptase-PCR. BDNF and MEK1 mRNA levels were significantly reduced in patients with major depressive disorder when compared with healthy controls (BDNF: P<0.01; MEK1: P<0.001), as well as among treatment-resistant depressive patients as compared with treatment-responsive depressive patients (BDNF: P<0.001; MEK1: P<0.01). Our findings support the hypothesis that BDNF and MEK1 mRNA expression levels are more obviously decreased in patients with TRD.Entities:
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Year: 2014 PMID： 24709918 PMCID： PMC4465888 DOI： 10.1097/WNR.0000000000000165
Source DB: PubMed Journal: Neuroreport ISSN： 0959-4965 Impact factor: 1.837