Casparis S1, Borm J M1, Tomic M A1, Burkhardt A2, Locher M C1. 1. Faculty, Oral Surgery, Center of Dental Medicine, University of Zurich , Switzerland . 2. Faculty, Institute of Pathology , Reutlingen, Germany .
Abstract
INTRODUCTION: The Oral CDx® brush biopsy (BB) method is a computer-assisted sample analysis that detects abnormal cells in all cell layers of the epithelium of the oral mucosa. METHOD: We took 263 oral BBs from 200 patients with potentially malignant disorders. RESULTS: We received 204 negative results and 39 atypical, 7 positive and 13 inadequate results. SBs were taken in 56 cases. Therefore, the sensitivity for the detection of abnormal cells was 90% and the specificity was 44.1%. The positive predictive value accounted for 47.2% and the NPV accounted for 88.2%. DISCUSSION AND CONCLUSION: For the results of sensitivity and specificity of the Oral CDx® BB, there is still space for improvement but they are already high. Additional methods like DNA-image cytometry may enhance the results. But it is a simple and noninvasive method which does not need a special effort either from the patient or from the clinicians.
INTRODUCTION: The Oral CDx® brush biopsy (BB) method is a computer-assisted sample analysis that detects abnormal cells in all cell layers of the epithelium of the oral mucosa. METHOD: We took 263 oral BBs from 200 patients with potentially malignant disorders. RESULTS: We received 204 negative results and 39 atypical, 7 positive and 13 inadequate results. SBs were taken in 56 cases. Therefore, the sensitivity for the detection of abnormal cells was 90% and the specificity was 44.1%. The positive predictive value accounted for 47.2% and the NPV accounted for 88.2%. DISCUSSION AND CONCLUSION: For the results of sensitivity and specificity of the Oral CDx® BB, there is still space for improvement but they are already high. Additional methods like DNA-image cytometry may enhance the results. But it is a simple and noninvasive method which does not need a special effort either from the patient or from the clinicians.
Authors: Fangyi Gu; Eduardo Cortes Gomez; Jianhong Chen; Matthew F Buas; Nicolas F Schlecht; Karen Hulme; Shweta Vishwas Kulkarni; Prashant K Singh; Richard O'Connor; Christine B Ambrosone; Anurag K Singh; Jianmin Wang Journal: J Circadian Rhythms Date: 2021-06-17