Literature DB >> 19884379

Hydrolysis and inhibition profiles of beta-lactamases from molecular classes A to D with doripenem, imipenem, and meropenem.

Anne Marie Queenan1, Wenchi Shang, Robert Flamm, Karen Bush.   

Abstract

The stability of doripenem to hydrolysis by beta-lactamases from molecular classes A to D was compared to the stability for imipenem and meropenem. Doripenem was stable to hydrolysis by extended-spectrum beta-lactamases and AmpC type beta-lactamases and demonstrated high affinity for the AmpC enzymes. For the serine carbapenemases SME-3 and KPC-2 and metallo-beta-lactamases IMP-1 and VIM-2, doripenem hydrolysis was generally 2- to 150-fold slower than imipenem hydrolysis. SPM-1 hydrolyzed meropenem and doripenem fourfold faster than imipenem.

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Year:  2009        PMID： 19884379      PMCID： PMC2798497          DOI： 10.1128/AAC.01004-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  In vitro antimicrobial activity of doripenem, a new carbapenem.

Authors:  Yigong Ge; Matthew A Wikler; Daniel F Sahm; Renée S Blosser-Middleton; James A Karlowsky
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191

2.  Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria.

Authors:  K Bush; J S Freudenberger; R B Sykes
Journal:  Antimicrob Agents Chemother       Date:  1982-09       Impact factor: 5.191

3.  Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction.

Authors:  Y Cheng; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858

4.  Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.

Authors:  R B Sykes; D P Bonner; K Bush; N H Georgopapadakou
Journal:  Antimicrob Agents Chemother       Date:  1982-01       Impact factor: 5.191

5.  Doripenem versus Pseudomonas aeruginosa in vitro: activity against characterized isolates, mutants, and transconjugants and resistance selection potential.

Authors:  Shazad Mushtaq; Yigong Ge; David M Livermore
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

6.  Carbapenem-resistant strain of Klebsiella oxytoca harboring carbapenem-hydrolyzing beta-lactamase KPC-2.

Authors:  Hesna Yigit; Anne Marie Queenan; J Kamile Rasheed; James W Biddle; Antonio Domenech-Sanchez; Sebastian Alberti; Karen Bush; Fred C Tenover
Journal:  Antimicrob Agents Chemother       Date:  2003-12       Impact factor: 5.191

7.  Resistance caused by decreased penetration of beta-lactam antibiotics into Enterobacter cloacae.

Authors:  K Bush; S K Tanaka; D P Bonner; R B Sykes
Journal:  Antimicrob Agents Chemother       Date:  1985-04       Impact factor: 5.191

8.  Biochemical characterization of the acquired metallo-beta-lactamase SPM-1 from Pseudomonas aeruginosa.

Authors:  Tanya A Murphy; Alan M Simm; Mark A Toleman; Ronald N Jones; Timothy R Walsh
Journal:  Antimicrob Agents Chemother       Date:  2003-02       Impact factor: 5.191

9.  A comparative study of class-D beta-lactamases.

Authors:  P Ledent; X Raquet; B Joris; J Van Beeumen; J M Frère
Journal:  Biochem J       Date:  1993-06-01       Impact factor: 3.857

10.  Comparative activities of doripenem versus isolates, mutants, and transconjugants of Enterobacteriaceae and Acinetobacter spp. with characterized beta-lactamases.

Authors:  Shazad Mushtaq; Yigong Ge; David M Livermore
Journal:  Antimicrob Agents Chemother       Date:  2004-04       Impact factor: 5.191
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  47 in total

1.  In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin against multidrug-resistant Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli.

Authors:  Carl Urban; Noriel Mariano; James J Rahal
Journal:  Antimicrob Agents Chemother       Date:  2010-04-05       Impact factor: 5.191

2.  A novel New Delhi metallo-β-lactamase variant, NDM-14, isolated in a Chinese Hospital possesses increased enzymatic activity against carbapenems.

Authors:  Dayang Zou; Yong Huang; Xiangna Zhao; Wei Liu; Derong Dong; Huan Li; Xuesong Wang; Simo Huang; Xiao Wei; Xiabei Yan; Zhan Yang; Yigang Tong; Liuyu Huang; Jing Yuan
Journal:  Antimicrob Agents Chemother       Date:  2015-02-02       Impact factor: 5.191

3.  Biochemical analysis of metallo-β-lactamase NDM-3 from a multidrug-resistant Escherichia coli strain isolated in Japan.

Authors:  Tatsuya Tada; Tohru Miyoshi-Akiyama; Kayo Shimada; Teruo Kirikae
Journal:  Antimicrob Agents Chemother       Date:  2014-03-31       Impact factor: 5.191

Review 4.  Development of novel antibacterial drugs to combat multiple resistant organisms.

Authors:  Matteo Bassetti; Elda Righi
Journal:  Langenbecks Arch Surg       Date:  2015-02-11       Impact factor: 3.445

Review 5.  Molecular mechanisms of antibiotic resistance.

Authors:  Jessica M A Blair; Mark A Webber; Alison J Baylay; David O Ogbolu; Laura J V Piddock
Journal:  Nat Rev Microbiol       Date:  2014-12-01       Impact factor: 60.633

6.  Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal.

Authors:  Basudha Shrestha; Tatsuya Tada; Tohru Miyoshi-Akiyama; Kayo Shimada; Hiroshi Ohara; Teruo Kirikae; Bharat M Pokhrel
Journal:  Antimicrob Agents Chemother       Date:  2015-07-13       Impact factor: 5.191

7.  Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics.

Authors:  Carolina Alvarez-Ortega; Irith Wiegand; Jorge Olivares; Robert E W Hancock; José Luis Martínez
Journal:  Antimicrob Agents Chemother       Date:  2010-08-02       Impact factor: 5.191

8.  NDM-8 metallo-β-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal.

Authors:  Tatsuya Tada; Tohru Miyoshi-Akiyama; Rajan K Dahal; Manoj K Sah; Hiroshi Ohara; Teruo Kirikae; Bharat M Pokhrel
Journal:  Antimicrob Agents Chemother       Date:  2013-03-04       Impact factor: 5.191

9.  Characterization of porin expression in Klebsiella pneumoniae Carbapenemase (KPC)-producing K. pneumoniae identifies isolates most susceptible to the combination of colistin and carbapenems.

Authors:  Jae H Hong; Cornelius J Clancy; Shaoji Cheng; Ryan K Shields; Liang Chen; Yohei Doi; Yanan Zhao; David S Perlin; Barry N Kreiswirth; M Hong Nguyen
Journal:  Antimicrob Agents Chemother       Date:  2013-03-04       Impact factor: 5.191

10.  IMP-51, a novel IMP-type metallo-β-lactamase with increased doripenem- and meropenem-hydrolyzing activities, in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.

Authors:  Tatsuya Tada; Pham Hong Nhung; Tohru Miyoshi-Akiyama; Kayo Shimada; Doan Mai Phuong; Nguyen Quoc Anh; Norio Ohmagari; Teruo Kirikae
Journal:  Antimicrob Agents Chemother       Date:  2015-08-17       Impact factor: 5.191
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