B Bartali1, E Devore, F Grodstein, J H Kang. 1. B. Bartali, New England Research Institutes, Epidemiology, 9 Galen St., Watertown, MA, Email: bbartali@neriscience.com, Phone number: 617-972-8350, Fax number: 617-924-0968.
Abstract
BACKGROUND: Vitamin D may play a role in preserving cognitive function. However, there is a paucity of prospective studies on the relationship between vitamin D and cognition with aging. The aim of this study was to examine the association between plasma levels of vitamin D and subsequent cognitive function. METHODS: This is a prospective study including 1,185 women aged 60-70 years from the Nurses' Health Study, who had plasma 25-hydroxy-vitamin D levels measured in 1989-1990 and completed an initial Telephone Interview of Cognitive Status approximately 9 years later. Subsequently, three follow-up cognitive assessments were conducted at 1.5-2.0 years intervals. We used multivariable-adjusted linear regression to model initial cognitive function, and mixed linear regression to model change in cognitive function over time. RESULTS: Lower vitamin D levels were associated with significantly worse cognitive function 9 years later. For example, the mean global composite score averaging all the cognitive tests was 0.20 lower (95% Confidence Interval (CI):-0.33,-0.08; p-trend=0.009) in women in the lowest quintile (median=14.1 ng/mL) compared with women in the highest quintile of vitamin D (median=38.4 ng/mL). The observed differences were equivalent to the effect estimates we found for women who were approximately 4-6 years apart in age. However, vitamin D levels were not significantly associated with subsequent cognitive decline during 6 years of follow-up. CONCLUSIONS: Higher levels of plasma vitamin D in women aged 60-70 years were associated with better cognitive function about a decade later but were not associated with cognitive decline during 6 years of follow-up.
BACKGROUND:Vitamin D may play a role in preserving cognitive function. However, there is a paucity of prospective studies on the relationship between vitamin D and cognition with aging. The aim of this study was to examine the association between plasma levels of vitamin D and subsequent cognitive function. METHODS: This is a prospective study including 1,185 women aged 60-70 years from the Nurses' Health Study, who had plasma 25-hydroxy-vitamin D levels measured in 1989-1990 and completed an initial Telephone Interview of Cognitive Status approximately 9 years later. Subsequently, three follow-up cognitive assessments were conducted at 1.5-2.0 years intervals. We used multivariable-adjusted linear regression to model initial cognitive function, and mixed linear regression to model change in cognitive function over time. RESULTS: Lower vitamin D levels were associated with significantly worse cognitive function 9 years later. For example, the mean global composite score averaging all the cognitive tests was 0.20 lower (95% Confidence Interval (CI):-0.33,-0.08; p-trend=0.009) in women in the lowest quintile (median=14.1 ng/mL) compared with women in the highest quintile of vitamin D (median=38.4 ng/mL). The observed differences were equivalent to the effect estimates we found for women who were approximately 4-6 years apart in age. However, vitamin D levels were not significantly associated with subsequent cognitive decline during 6 years of follow-up. CONCLUSIONS: Higher levels of plasma vitamin D in women aged 60-70 years were associated with better cognitive function about a decade later but were not associated with cognitive decline during 6 years of follow-up.
Authors: Robert S Wilson; Julie A Schneider; Lisa L Barnes; Laurel A Beckett; Neelum T Aggarwal; Elizabeth J Cochran; Elizabeth Berry-Kravis; Julie Bach; Jacob H Fox; Denis A Evans; David A Bennett Journal: Arch Neurol Date: 2002-07
Authors: May A Beydoun; Sharmin Hossain; Marie T Fanelli-Kuczmarski; Hind A Beydoun; Jose-Atilio Canas; Michele K Evans; Alan B Zonderman Journal: J Clin Endocrinol Metab Date: 2018-04-01 Impact factor: 5.958
Authors: Andrea L C Schneider; Di Zhao; Pamela L Lutsey; Rebecca F Gottesman; A Richey Sharrett; Andreea M Rawlings; Alvaro Alonso; David Knopman; Thomas H Mosley; Elizabeth Selvin; Erin D Michos Journal: Neuroepidemiology Date: 2018-08-09 Impact factor: 3.282
Authors: Caroline S Duchaine; Denis Talbot; Mohamed Nafti; Yves Giguère; Sylvie Dodin; André Tourigny; Pierre-Hugues Carmichael; Danielle Laurin Journal: Can J Public Health Date: 2020-02-03
Authors: Virginie Lam; Matthew A Albrecht; Ryusuke Takechi; Prachya Prasopsang; Ya Ping Lee; Jonathan K Foster; John C L Mamo Journal: Eur J Nutr Date: 2015-07-01 Impact factor: 5.614
Authors: Margot J Overman; Neil Pendleton; Terence W O'Neill; Gyorgy Bartfai; Felipe F Casanueva; Joseph D Finn; Gianni Forti; Giulia Rastrelli; Aleksander Giwercman; Thang S Han; Ilpo T Huhtaniemi; Krzysztof Kula; Michael E J Lean; Margus Punab; David M Lee; Elon S Correa; Tomas Ahern; Sabine M P Verschueren; Leen Antonio; Evelien Gielen; Martin K Rutter; Dirk Vanderschueren; Frederick C W Wu; Jos Tournoy Journal: Eur J Nutr Date: 2016-07-01 Impact factor: 5.614
Authors: Janis D Harse; Kun Zhu; Romola S Bucks; Michael Hunter; Ee Mun Lim; Brian R Cooke; John P Walsh; Kevin Murray Journal: Int J Environ Res Public Health Date: 2021-12-31 Impact factor: 3.390