Caroline S Duchaine1,2,3,4,5, Denis Talbot1,2,3, Mohamed Nafti1,3, Yves Giguère2,6, Sylvie Dodin2,6,7, André Tourigny1,2,3,4,5, Pierre-Hugues Carmichael1,2,5, Danielle Laurin8,9,10,11,12,13. 1. Centre d'excellence sur le vieillissement de Québec, 1050 Chemin Sainte-Foy, Local L2-32, Quebec, QC, G1S 4L8, Canada. 2. CHU de Québec-Université Laval Research Centre, Quebec, QC, Canada. 3. Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec, QC, Canada. 4. Institut sur le vieillissement et la participation sociale des aînés de l'Université Laval, Quebec, Canada. 5. Centre de recherche sur les soins et les services de première ligne de l'Université Laval, CIUSSS-CN, Quebec, QC, Canada. 6. Faculty of Medicine, Laval University, Quebec, QC, Canada. 7. Institut sur la nutrition et les aliments fonctionnels, Laval University, Quebec, Canada. 8. Centre d'excellence sur le vieillissement de Québec, 1050 Chemin Sainte-Foy, Local L2-32, Quebec, QC, G1S 4L8, Canada. Danielle.Laurin@pha.ulaval.ca. 9. CHU de Québec-Université Laval Research Centre, Quebec, QC, Canada. Danielle.Laurin@pha.ulaval.ca. 10. Institut sur le vieillissement et la participation sociale des aînés de l'Université Laval, Quebec, Canada. Danielle.Laurin@pha.ulaval.ca. 11. Centre de recherche sur les soins et les services de première ligne de l'Université Laval, CIUSSS-CN, Quebec, QC, Canada. Danielle.Laurin@pha.ulaval.ca. 12. Institut sur la nutrition et les aliments fonctionnels, Laval University, Quebec, Canada. Danielle.Laurin@pha.ulaval.ca. 13. Faculty of Pharmacy, Laval University, Quebec, QC, Canada. Danielle.Laurin@pha.ulaval.ca.
Abstract
OBJECTIVE: Vitamin D could prevent cognitive decline because of its neuroprotective, anti-inflammatory and antioxidant properties. This study aimed to evaluate the associations of plasma 25-hydroxyvitamin D (25(OH)D) concentrations with global cognitive function and incident dementia, including Alzheimer's disease (AD). METHODS: The Canadian Study of Health and Aging is a 10-year cohort study of a representative sample of individuals aged 65 years or older. A total of 661 subjects initially without dementia with frozen blood samples and follow-up data were included. Global cognitive function was measured using the validated Modified Mini-Mental State (3MS) examination. A consensus diagnosis of all-cause dementia and AD was made between the physician and the neuropsychologist according to published criteria. Cognitive decline for a 5-year increase in age at specific 25(OH)D concentrations was obtained using linear mixed models with repeated measures. Hazard ratios of incident dementia and AD were obtained using semi-parametric proportional hazards models with age as time scale. RESULTS: Over a mean follow-up of 5.4 years, 141 subjects developed dementia of which 100 were AD. Overall, no significant association was found between 25(OH)D and cognitive decline, dementia or AD. Higher 25(OH)D concentrations were associated with an increased risk of dementia and AD in women, but not in men. CONCLUSION: This study does not support a protective effect of vitamin D status on cognitive function. Further research is needed to clarify the relation by sex.
OBJECTIVE:Vitamin D could prevent cognitive decline because of its neuroprotective, anti-inflammatory and antioxidant properties. This study aimed to evaluate the associations of plasma 25-hydroxyvitamin D (25(OH)D) concentrations with global cognitive function and incident dementia, including Alzheimer's disease (AD). METHODS: The Canadian Study of Health and Aging is a 10-year cohort study of a representative sample of individuals aged 65 years or older. A total of 661 subjects initially without dementia with frozen blood samples and follow-up data were included. Global cognitive function was measured using the validated Modified Mini-Mental State (3MS) examination. A consensus diagnosis of all-cause dementia and AD was made between the physician and the neuropsychologist according to published criteria. Cognitive decline for a 5-year increase in age at specific 25(OH)D concentrations was obtained using linear mixed models with repeated measures. Hazard ratios of incident dementia and AD were obtained using semi-parametric proportional hazards models with age as time scale. RESULTS: Over a mean follow-up of 5.4 years, 141 subjects developed dementia of which 100 were AD. Overall, no significant association was found between 25(OH)D and cognitive decline, dementia or AD. Higher 25(OH)D concentrations were associated with an increased risk of dementia and AD in women, but not in men. CONCLUSION: This study does not support a protective effect of vitamin D status on cognitive function. Further research is needed to clarify the relation by sex.
Entities:
Keywords:
25-hydroxyvitamin D; Alzheimer disease; Cognitive impairment; Prospective study
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