Cristiano T Mostarda1, Bruno Rodrigues2, Oscar Albuquerque de Moraes3, Ivana C Moraes-Silva1, Paula Barros Olinto Arruda1, Ruymar Cardoso1, Katia Bilhar Scapini1, Fernando Dos Santos1, Kátia De Angelis4, Maria Cláudia Irigoyen5. 1. Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil. 2. Human Movement Laboratory, Universidade São Judas Tadeu UST, São Paulo/SP, Brazil. 3. Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil; Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo/SP, Brazil. 4. Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), São Paulo/SP, Brazil. 5. Hypertension Unit, Heart Institute (InCor), Medical School of University of São Paulo, São Paulo/SP, Brazil. Electronic address: hipirigoyen@incor.usp.br.
Abstract
AIMS: We evaluated the effects of low intensity resistance training (RT) on left ventricular (LV) function, baroreflex sensitivity (BRS), and cardiovascular autonomic control of streptozotocin-induced diabetic rats. METHODS: Male Wistar rats were divided into (n=8 each group): sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). Trained groups underwent low intensity RT (40%-50% 1 repetition maximum) for 10 weeks. Echocardiographic evaluation, arterial pressure (AP), heart rate (HR), BRS, and autonomic measurements were performed. RESULTS: Diabetes induced an increase in glycemia and a reduction in body weight in diabetics when compared with control animals. Diabetic rats displayed cardiac dysfunction, reduced systolic AP and HR, impaired BRS and autonomic derangement when compared to control rats. RT improved ejection fraction (SD: 68%±1.3% vs. TD: 75%±3.0%) and velocity of circumferential fiber shortening (SD: 0.32±0.02 vs. TD: 0.40±0.01 circ/seg.10(-4)). Trained diabetic rats presented increased AP (+10.2%), HR (+10.4%), and BRS after RT protocol. CONCLUSIONS: Low intensity RT induced an increase in systolic function in diabetic rats. This may be due to positive LV remodeling and BRS improvement, which may have played an important role in the attenuation of hemodynamic impairment and cardiac autonomic neuropathy in streptozotocin-diabetic rats.
AIMS: We evaluated the effects of low intensity resistance training (RT) on left ventricular (LV) function, baroreflex sensitivity (BRS), and cardiovascular autonomic control of streptozotocin-induced diabeticrats. METHODS: Male Wistar rats were divided into (n=8 each group): sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). Trained groups underwent low intensity RT (40%-50% 1 repetition maximum) for 10 weeks. Echocardiographic evaluation, arterial pressure (AP), heart rate (HR), BRS, and autonomic measurements were performed. RESULTS:Diabetes induced an increase in glycemia and a reduction in body weight in diabetics when compared with control animals. Diabeticrats displayed cardiac dysfunction, reduced systolic AP and HR, impaired BRS and autonomic derangement when compared to control rats. RT improved ejection fraction (SD: 68%±1.3% vs. TD: 75%±3.0%) and velocity of circumferential fiber shortening (SD: 0.32±0.02 vs. TD: 0.40±0.01 circ/seg.10(-4)). Trained diabeticrats presented increased AP (+10.2%), HR (+10.4%), and BRS after RT protocol. CONCLUSIONS: Low intensity RT induced an increase in systolic function in diabeticrats. This may be due to positive LV remodeling and BRS improvement, which may have played an important role in the attenuation of hemodynamic impairment and cardiac autonomic neuropathy in streptozotocin-diabeticrats.
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