Literature DB >> 2460859

Induction of anti-human immunodeficiency virus (HIV) neutralizing antibodies in rabbits immunized with recombinant HIV--hepatitis B surface antigen particles.

M L Michel1, M Mancini, E Sobczak, V Favier, D Guetard, E M Bahraoui, P Tiollais.   

Abstract

Fragments of the human immunodeficiency virus (HIV) envelope coding region have been fused with the hepatitis B virus envelope middle protein. In this system, HIV antigenic determinants are exposed at the surface of a highly antigenic structure, the hepatitis B surface antigen particle. Immunization of rabbits with these particles elicited antibodies directed against both parts of the hybrid protein. One of the rabbit antisera not only exhibited a neutralizing effect on the original HIV1 isolate but also on a divergent Zairian isolate. The HIV sequence in this recombinant is 84 amino acids long and contains conserved and variable domains and a region critical for interaction with the CD4 receptor. Such recombinant antigens could be primary elements in the design of a polyvalent vaccine.

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Year:  1988        PMID： 2460859      PMCID： PMC282332          DOI： 10.1073/pnas.85.21.7957

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor.

Authors:  L A Lasky; G Nakamura; D H Smith; C Fennie; C Shimasaki; E Patzer; P Berman; T Gregory; D J Capon
Journal:  Cell       Date:  1987-09-11       Impact factor: 41.582

2.  Presentation of two epitopes of the preS2 region of hepatitis B virus on live recombinant bacteria.

Authors:  A Charbit; E Sobczak; M L Michel; A Molla; P Tiollais; M Hofnung
Journal:  J Immunol       Date:  1987-09-01       Impact factor: 5.422

3.  New versatile cloning and sequencing vectors based on bacteriophage M13.

Authors:  M P Kieny; R Lathe; J P Lecocq
Journal:  Gene       Date:  1983-12       Impact factor: 3.688

4.  Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA.

Authors:  B A Parker; G R Stark
Journal:  J Virol       Date:  1979-08       Impact factor: 5.103

5.  A polypeptide containing 55 amino acid residues coded by the pre-S region of hepatitis B virus deoxyribonucleic acid bears the receptor for polymerized human as well as chimpanzee albumins.

Authors:  A Machida; S Kishimoto; H Ohnuma; K Baba; Y Ito; H Miyamoto; G Funatsu; K Oda; S Usuda; S Togami
Journal:  Gastroenterology       Date:  1984-05       Impact factor: 22.682

6.  Synthesis in animal cells of hepatitis B surface antigen particles carrying a receptor for polymerized human serum albumin.

Authors:  M L Michel; P Pontisso; E Sobczak; Y Malpièce; R E Streeck; P Tiollais
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

7.  Chemically synthesized peptides of hepatitis B surface antigen duplicate the d/y specificities and induce subtype-specific antibodies in chimpanzees.

Authors:  J L Gerin; H Alexander; J W Shih; R H Purcell; G Dapolito; R Engle; N Green; J G Sutcliffe; T M Shinnick; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

8.  Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

Authors:  G Urlaub; L A Chasin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

9.  Characterization of the RNA dependent DNA polymerase of a new human T-lymphotropic retrovirus (lymphadenopathy associated virus).

Authors:  M A Rey; B Spire; D Dormont; F Barre-Sinoussi; L Montagnier; J C Chermann
Journal:  Biochem Biophys Res Commun       Date:  1984-05-31       Impact factor: 3.575

10.  Location and chemical synthesis of a pre-S gene coded immunodominant epitope of hepatitis B virus.

Authors:  A R Neurath; S B Kent; N Strick
Journal:  Science       Date:  1984-04-27       Impact factor: 47.728
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  22 in total

Review 1.  Cellular and humoral antigenic epitopes in HIV and SIV.

Authors:  D F Nixon; K Broliden; G Ogg; P A Broliden
Journal:  Immunology       Date:  1992-08       Impact factor: 7.397

2.  Mutational analysis of hepatitis B surface antigen particle assembly and secretion.

Authors:  V Bruss; D Ganem
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

3.  Low-dose adenovirus vaccine encoding chimeric hepatitis B virus surface antigen-human papillomavirus type 16 E7 proteins induces enhanced E7-specific antibody and cytotoxic T-cell responses.

Authors:  Andrés Báez-Astúa; Elsa Herráez-Hernández; Natalio Garbi; Hilda A Pasolli; Victoria Juárez; Harald Zur Hausen; Angel Cid-Arregui
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

4.  Structural factors modulate the activity of antigenic poliovirus sequences expressed on hybrid hepatitis B surface antigen particles.

Authors:  F Delpeyroux; E Van Wezel; B Blondel; R Crainic
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

Review 5.  Gene vaccination for hepatitis C.

Authors:  G Inchauspé
Journal:  Springer Semin Immunopathol       Date:  1997

6.  Immunization with plasmid DNA encoding hepatitis C virus envelope E2 antigenic domains induces antibodies whose immune reactivity is linked to the injection mode.

Authors:  I Nakano; G Maertens; M E Major; L Vitvitski; J Dubuisson; A Fournillier; G De Martynoff; C Trepo; G Inchauspe
Journal:  J Virol       Date:  1997-09       Impact factor: 5.103

7.  Immunogenicity of peptide fusions to hepatitis B virus core antigen.

Authors:  S J Stahl; K Murray
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

8.  Antigenicity and immunogenicity of novel chimeric hepatitis B surface antigen particles with exposed hepatitis C virus epitopes.

Authors:  H J Netter; T B Macnaughton; W P Woo; R Tindle; E J Gowans
Journal:  J Virol       Date:  2001-03       Impact factor: 5.103

9.  Expression and characterization of virus-like particles containing rubella virus structural proteins.

Authors:  Z Qiu; D Ou; T C Hobman; S Gillam
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

10.  Human immunodeficiency virus type 1 major neutralizing determinant exposed on hepatitis B surface antigen particles is highly immunogenic in primates.

Authors:  K Schlienger; M Mancini; Y Rivière; D Dormont; P Tiollais; M L Michel
Journal:  J Virol       Date:  1992-04       Impact factor: 5.103
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