Victor Ianculescu1, Laura Maria Ciolovan1, Ariane Dunant2, Philippe Vielh3, Chafika Mazouni4, Suzette Delaloge5, Clarisse Dromain1, Alexandru Blidaru6, Corinne Balleyguier7. 1. Radiology Department, Gustave Roussy, Villejuif, France. 2. Department of Statistics, Gustave Roussy, Villejuif, France. 3. Department of Biopathology, Gustave Roussy, Villejuif, France. 4. Department of Surgery, Gustave Roussy, Villejuif, France. 5. Department of Oncology, Gustave Roussy, Villejuif, France. 6. Department of Surgery, Bucharest Institute of Oncology, Bucharest, Romania. 7. Radiology Department, Gustave Roussy, Villejuif, France; UMR 8081, IR4M, Paris-Sud University, 91405 Orsay, France. Electronic address: corinne.balleyguier@gustaveroussy.fr.
Abstract
PURPOSE: To determine the diagnostic performance of Acoustic Radiation Force Impulse (ARFI) Virtual Touch IQ shear wave elastography in the discrimination of benign and malignant breast lesions. MATERIALS AND METHODS: Conventional B-mode and elasticity imaging were used to evaluate 110 breast lesions. Elastographic assessment of breast tissue abnormalities was done using a shear wave based technique, Virtual Touch IQ (VTIQ), implemented on a Siemens Acuson S3000 ultrasound machine. Tissue mechanical properties were interpreted as two-dimensional qualitative and quantitative colour maps displaying relative shear wave velocity. Wave speed measurements in m/s were possible at operator defined regions of interest. The pathologic diagnosis was established on samples obtained by ultrasound guided core biopsy or fine needle aspiration. RESULTS: BIRADS based B-mode evaluation of the 48 benign and 62 malignant lesions achieved 92% sensitivity and 62.5% specificity. Subsequently performed VTIQ elastography relying on visual interpretation of the colour overlay displaying relative shear wave velocities managed similar standalone diagnostic performance with 92% sensitivity and 64.6% specificity. Lesion and surrounding tissue shear wave speed values were calculated and a significant difference was found between the benign and malignant populations (Mann-Whitney U test, p<0.0001). By selecting a lesion cut-off value of 3.31m/s we achieved 80.4% sensitivity and 73% specificity. Applying this threshold only to BIRADS 4a masses, we reached overall levels of 92% sensitivity and 72.9% specificity. CONCLUSION: VTIQ qualitative and quantitative elastography has the potential to further characterise B-mode detected breast lesions, increasing specificity and reducing the number of unnecessary biopsies.
PURPOSE: To determine the diagnostic performance of Acoustic Radiation Force Impulse (ARFI) Virtual Touch IQ shear wave elastography in the discrimination of benign and malignant breast lesions. MATERIALS AND METHODS: Conventional B-mode and elasticity imaging were used to evaluate 110 breast lesions. Elastographic assessment of breast tissue abnormalities was done using a shear wave based technique, Virtual Touch IQ (VTIQ), implemented on a Siemens Acuson S3000 ultrasound machine. Tissue mechanical properties were interpreted as two-dimensional qualitative and quantitative colour maps displaying relative shear wave velocity. Wave speed measurements in m/s were possible at operator defined regions of interest. The pathologic diagnosis was established on samples obtained by ultrasound guided core biopsy or fine needle aspiration. RESULTS: BIRADS based B-mode evaluation of the 48 benign and 62 malignant lesions achieved 92% sensitivity and 62.5% specificity. Subsequently performed VTIQ elastography relying on visual interpretation of the colour overlay displaying relative shear wave velocities managed similar standalone diagnostic performance with 92% sensitivity and 64.6% specificity. Lesion and surrounding tissue shear wave speed values were calculated and a significant difference was found between the benign and malignant populations (Mann-Whitney U test, p<0.0001). By selecting a lesion cut-off value of 3.31m/s we achieved 80.4% sensitivity and 73% specificity. Applying this threshold only to BIRADS 4a masses, we reached overall levels of 92% sensitivity and 72.9% specificity. CONCLUSION: VTIQ qualitative and quantitative elastography has the potential to further characterise B-mode detected breast lesions, increasing specificity and reducing the number of unnecessary biopsies.
Authors: Xiao W Bo; Xiao L Li; Hui X Xu; Le H Guo; Dan D Li; Bo J Liu; Dan Wang; Ya P He; Xiao H Xu Journal: Br J Radiol Date: 2016 Impact factor: 3.039
Authors: Andrea B Rosskopf; Elias Bachmann; Jess G Snedeker; Christian W A Pfirrmann; Florian M Buck Journal: Skeletal Radiol Date: 2016-09-08 Impact factor: 2.199