Literature DB >> 24570297

Proactive pharmaceutical care interventions decrease patients' nonadherence to osteoporosis medication.

A G G Stuurman-Bieze1, E G Hiddink, J F M van Boven, S Vegter.   

Abstract

UNLABELLED: Using a protocolled intervention program, pharmacists can decrease nonadherence to osteoporosis medication, by continuous monitoring and tailored counseling sessions, starting at treatment initiation. In the usual care group, 32.8% of patients initiating osteoporosis medication discontinued or were nonadherent, compared to 19.0% of patients in the intervention group.
PURPOSE: While community pharmacies have been shown to offer a promising platform for osteoporosis management in patients with osteoporosis, more research is needed to determine pharmacists' effects on improving adherence. The aim of this study was to determine the effects of a community pharmacists' intervention program on the 1-year discontinuation and nonadherence rates of patients initiating osteoporosis medication.
METHODS: This intervention study included 937 patients, recruited from 13 Dutch community pharmacies, initiating osteoporosis medication. The intervention group (N = 495), received the Medication Monitoring and Optimization (MeMO) intervention, comprising of continuous monitoring of patients' adherence to their osteoporosis medication and tailored counseling sessions with nonadherent patients. Results were compared to an internal (n = 442) reference group, receiving usual pharmacy care. Primary study outcomes were therapy discontinuation and nonadherence; results were adjusted for potential confounders using Cox proportional hazard analysis. Secondary outcome was patients' satisfaction.
RESULTS: In the usual care group, 32.8% of patients initiating osteoporosis medication discontinued or were nonadherent, compared to 19.0% of patients in the intervention group (P < 0.001). Ninety-three percent of the respondents were satisfied with the pharmacies' services provided. Notably, 31% mentioned that the pharmacy was the only place where they received information on various aspects of administration and acting of their medication.
CONCLUSION: Pharmacists can decrease nonadherence and discontinuation with osteoporosis medication by providing tailored counseling sessions and continuous monitoring of drug use. Pharmaceutical care programs, such as MeMO, contribute to more optimal use of osteoporosis medication.

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Year:  2014        PMID: 24570297     DOI: 10.1007/s00198-014-2659-8

Source DB:  PubMed          Journal:  Osteoporos Int        ISSN: 0937-941X            Impact factor:   4.507


  19 in total

1.  The clinical and economic burden of non-adherence with oral bisphosphonates in osteoporotic patients.

Authors:  Mickaël Hiligsmann; Véronique Rabenda; Olivier Bruyère; Jean-Yves Reginster
Journal:  Health Policy       Date:  2010-02-13       Impact factor: 2.980

2.  Effects of pharmaceutical care on adherence and persistence to bisphosphonates in postmenopausal osteoporotic women.

Authors:  P S M Lai; S S Chua; Y Y Chew; S P Chan
Journal:  J Clin Pharm Ther       Date:  2010-10-26       Impact factor: 2.512

3.  An evaluation of managing and educating patients on the risk of glucocorticoid-induced osteoporosis.

Authors:  Randy P McDonough; William R Doucette; Patty Kumbera; Donald G Klepser
Journal:  Value Health       Date:  2005 Jan-Feb       Impact factor: 5.725

4.  Proactive pharmaceutical care interventions improve patients' adherence to lipid-lowering medication.

Authors:  Ada G G Stuurman-Bieze; Eric G Hiddink; Job F M van Boven; Stefan Vegter
Journal:  Ann Pharmacother       Date:  2013-11-18       Impact factor: 3.154

Review 5.  Quality of life in patients with osteoporosis.

Authors:  Paul Lips; Natasja M van Schoor
Journal:  Osteoporos Int       Date:  2004-12-18       Impact factor: 4.507

Review 6.  Poor bisphosphonate adherence for treatment of osteoporosis increases fracture risk: systematic review and meta-analysis.

Authors:  I Imaz; P Zegarra; J González-Enríquez; B Rubio; R Alcazar; J M Amate
Journal:  Osteoporos Int       Date:  2009-12-05       Impact factor: 4.507

Review 7.  Interventions to improve adherence and persistence with osteoporosis medications: a systematic literature review.

Authors:  T Gleeson; M D Iversen; J Avorn; A M Brookhart; J N Katz; E Losina; F May; A R Patrick; W H Shrank; D H Solomon
Journal:  Osteoporos Int       Date:  2009-06-05       Impact factor: 4.507

8.  Community pharmacist-initiated screening program for osteoporosis: randomized controlled trial.

Authors:  N Yuksel; S R Majumdar; C Biggs; R T Tsuyuki
Journal:  Osteoporos Int       Date:  2009-06-05       Impact factor: 4.507

9.  The population-based prescription database IADB.nl: its development, usefulness in outcomes research and challenges.

Authors:  Sipke T Visser; Catharina C M Schuiling-Veninga; Jens H J Bos; Lolkje T W de Jong-van den Berg; Maarten J Postma
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10.  Treatment persistence with once-monthly ibandronate and patient support vs. once-weekly alendronate: results from the PERSIST study.

Authors:  A Cooper; J Drake; E Brankin
Journal:  Int J Clin Pract       Date:  2006-06-19       Impact factor: 2.503

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  18 in total

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Authors:  Ayesha Jaleel; Kenneth G Saag; Maria I Danila
Journal:  Ther Adv Musculoskelet Dis       Date:  2018-07-10       Impact factor: 5.346

2.  Patient-reported reasons for nonadherence to recommended osteoporosis pharmacotherapy.

Authors:  Sylvie F Hall; Stephanie W Edmonds; Yiyue Lou; Peter Cram; Douglas W Roblin; Kenneth G Saag; Nicole C Wright; Michael P Jones; Fredric D Wolinsky
Journal:  J Am Pharm Assoc (2003)       Date:  2017-06-08

3.  One-year outcomes of an osteoporosis liaison services program initiated within a healthcare system.

Authors:  C-B Chang; R-S Yang; L-Y Chang; J-K Peng; K-S Tsai; W-J Huang; T-H Yang; D-C Chan
Journal:  Osteoporos Int       Date:  2021-05-06       Impact factor: 4.507

Review 4.  Supporting patients to get the best from their osteoporosis treatment: a rapid realist review of what works, for whom, and in what circumstance.

Authors:  Z Paskins; O Babatunde; A Sturrock; L S Toh; R Horne; I Maidment
Journal:  Osteoporos Int       Date:  2022-06-11       Impact factor: 5.071

5.  Evaluation of a Multimodal, Direct-to-Patient Educational Intervention Targeting Barriers to Osteoporosis Care: A Randomized Clinical Trial.

Authors:  Maria I Danila; Ryan C Outman; Elizabeth J Rahn; Amy S Mudano; David T Redden; Peng Li; Jeroan J Allison; Fred A Anderson; Allison Wyman; Susan L Greenspan; Andrea Z LaCroix; Jeri W Nieves; Stuart L Silverman; Ethel S Siris; Nelson B Watts; Michael J Miller; Jeffrey R Curtis; Amy H Warriner; Nicole C Wright; Kenneth G Saag
Journal:  J Bone Miner Res       Date:  2018-02-26       Impact factor: 6.741

6.  Exploring the current and future role of the pharmacists in osteoporosis screening and management in Malaysia.

Authors:  L S Toh; P S M Lai; S Othman; A Shah; C P L Dang; B Y Low; K T Wong; C Anderson
Journal:  Int J Clin Pharm       Date:  2018-01-29

Review 7.  Interventional tools to improve medication adherence: review of literature.

Authors:  Elísio Costa; Anna Giardini; Magda Savin; Enrica Menditto; Elaine Lehane; Olga Laosa; Sergio Pecorelli; Alessandro Monaco; Alessandra Marengoni
Journal:  Patient Prefer Adherence       Date:  2015-09-14       Impact factor: 2.711

8.  Long-term persistence with anti-osteoporosis drugs after fracture.

Authors:  C Klop; P M J Welsing; P J M Elders; J A Overbeek; P C Souverein; A M Burden; H A W van Onzenoort; H G M Leufkens; J W J Bijlsma; F de Vries
Journal:  Osteoporos Int       Date:  2015-03-31       Impact factor: 4.507

9.  Use of path modeling to inform a clinical decision support application to encourage osteoporosis medication use.

Authors:  Michael J Miller; Tzuchen Jou; Maria I Danila; Amy S Mudano; Elizabeth J Rahn; Ryan C Outman; Kenneth G Saag
Journal:  Res Social Adm Pharm       Date:  2020-09-20

10.  Trends in antithrombotic drug use and adherence to non-vitamin K oral anticoagulants in the Netherlands.

Authors:  Susan Hanemaaijer; Fong Sodihardjo; Annemieke Horikx; Michel Wensing; Peter A G M De Smet; Marcel L Bouvy; Martina Teichert
Journal:  Int J Clin Pharm       Date:  2015-08-05
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