Literature DB >> 24482163

Generation of closed transverse fractures in small animals.

Anthony De Giacomo1, Elise F Morgan1, Louis C Gerstenfeld1.   

Abstract

The most common procedure that has been developed for use in rats and mice to model fracture healing is described. The nature of the regenerative processes that may be assessed and the types of research questions that may be addressed with this model are briefly outlined. The detailed surgical protocol to generate closed simple transverse fractures is presented, and general considerations when setting up an experiment using this model are described.

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Year:  2014        PMID： 24482163      PMCID： PMC4464673          DOI： 10.1007/978-1-62703-989-5_3

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  31 in total

1.  Genetic variation in the patterns of skeletal progenitor cell differentiation and progression during endochondral bone formation affects the rate of fracture healing.

Authors:  Karl J Jepsen; Christopher Price; Lee J Silkman; Fred H Nicholls; Phillip Nasser; Bin Hu; Nicole Hadi; Michael Alapatt; Stephanie N Stapleton; Sanjeev Kakar; Thomas A Einhorn; Louis C Gerstenfeld
Journal:  J Bone Miner Res       Date:  2008-08       Impact factor: 6.741

2.  Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing.

Authors:  T Kon; T J Cho; T Aizawa; M Yamazaki; N Nooh; D Graves; L C Gerstenfeld; T A Einhorn
Journal:  J Bone Miner Res       Date:  2001-06       Impact factor: 6.741

3.  Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats.

Authors:  R A Meyer; P J Tsahakis; D F Martin; D M Banks; M E Harrow; G M Kiebzak
Journal:  J Orthop Res       Date:  2001-05       Impact factor: 3.494

4.  Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair.

Authors:  Xinping Zhang; Edward M Schwarz; Donald A Young; J Edward Puzas; Randy N Rosier; Regis J O'Keefe
Journal:  J Clin Invest       Date:  2002-06       Impact factor: 14.808

5.  Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects.

Authors:  Yan-yiu Yu; Chelsea Bahney; Diane Hu; Ralph S Marcucio; Theodore Miclau
Journal:  J Vis Exp       Date:  2012-04-11       Impact factor: 1.355

6.  Mechanical characterization of external fixator stiffness for a rat femoral fracture model.

Authors:  Bettina Willie; Kyle Adkins; Xing Zheng; Ulrich Simon; Lutz Claes
Journal:  J Orthop Res       Date:  2009-05       Impact factor: 3.494

7.  Cyclo-oxygenase 2 function is essential for bone fracture healing.

Authors:  Ann Marie Simon; Michaele Beth Manigrasso; J Patrick O'Connor
Journal:  J Bone Miner Res       Date:  2002-06       Impact factor: 6.741

8.  Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing.

Authors:  Louis C Gerstenfeld; Daniel J Sacks; Megan Pelis; Zachary D Mason; Dana T Graves; Mauricio Barrero; Michael S Ominsky; Paul J Kostenuik; Elise F Morgan; Thomas A Einhorn
Journal:  J Bone Miner Res       Date:  2009-02       Impact factor: 6.741

9.  Effect of age on vascularization during fracture repair.

Authors:  Chuanyong Lu; Erik Hansen; Anna Sapozhnikova; Diane Hu; Theodore Miclau; Ralph S Marcucio
Journal:  J Orthop Res       Date:  2008-10       Impact factor: 3.494

10.  Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures.

Authors:  Sanjeev Kakar; Thomas A Einhorn; Siddharth Vora; Lincoln J Miara; Gregory Hon; Nathan A Wigner; Daniel Toben; Kimberly A Jacobsen; Maisa O Al-Sebaei; Michael Song; Philip C Trackman; Elise F Morgan; Louis C Gerstenfeld; George L Barnes
Journal:  J Bone Miner Res       Date:  2007-12       Impact factor: 6.741
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  5 in total

Review 1.  A comprehensive review of mouse diaphyseal femur fracture models.

Authors:  Zachary J Gunderson; Zachery R Campbell; Todd O McKinley; Roman M Natoli; Melissa A Kacena
Journal:  Injury       Date:  2020-04-18       Impact factor: 2.586

2.  Correlation between RUST assessments of fracture healing to structural and biomechanical properties.

Authors:  Margaret E Cooke; Amira I Hussein; Kyle E Lybrand; Alexander Wulff; Erin Simmons; Jeffrey H Choi; Jody Litrenta; William M Ricci; Jason W Nascone; Robert V O'Toole; Elise F Morgan; Louis C Gerstenfeld; Paul Tornetta
Journal:  J Orthop Res       Date:  2017-09-20       Impact factor: 3.494

3.  A methodology for the generation and non-destructive characterisation of transverse fractures in long bones.

Authors:  Fernando Y Zapata-Cornelio; Zhongmin Jin; David C Barton; Alison C Jones; Ruth K Wilcox
Journal:  Bone Rep       Date:  2018-04-25

4.  A segmental defect adaptation of the mouse closed femur fracture model for the analysis of severely impaired bone healing.

Authors:  Amandeep Kaur; Subburaman Mohan; Charles H Rundle
Journal:  Animal Model Exp Med       Date:  2020-05-01

5.  Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy.

Authors:  C D Collier; B S Hausman; S H Zulqadar; E S Din; J M Anderson; O Akkus; E M Greenfield
Journal:  Bone Rep       Date:  2020-02-05
  5 in total

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