Dincer Yilmaz1, Necdet Dogan2, Aydin Ozkan3, Metin Sencimen2, Baris Eren Ora2, Ibrahim Mutlu2. 1. Ardahan Military Hospital, Ardahan, Turkey. 2. Gulhane Military Medical Academy, Dental Sciences Center, Department of Oral and Maxillofacial Surgery, Ankara, Turkey. 3. Land Forces Practice Center, Ankara, Turkey.
Abstract
PURPOSE: To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects. METHODS: Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically. RESULTS: Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone. CONCLUSION: The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.
PURPOSE: To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects. METHODS: Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically. RESULTS: Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone. CONCLUSION: The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.
Authors: Eduardo Borie; Daniel García Oliví; Iara Augusta Orsi; Katia Garlet; Benjamín Weber; Víctor Beltrán; Ramón Fuentes Journal: Int J Clin Exp Med Date: 2015-05-15
Authors: Helena Filipa Pereira; Ibrahim Fatih Cengiz; Filipe Samuel Silva; Rui Luís Reis; Joaquim Miguel Oliveira Journal: J Mater Sci Mater Med Date: 2020-03-02 Impact factor: 3.896
Authors: Tomasz Szponder; Joanna Wessely-Szponder; Aleksandra Sobczyńska-Rak; Beata Żylińska; Radosław P Radzki; Izabella Polkowska Journal: In Vivo Date: 2018 Nov-Dec Impact factor: 2.155