| Literature DB >> 24453034 |
Rubistenia Miranda Soares de Araújo1, Cynthia Farias Vieira de Melo, Fidelis Manes Neto, Juarez Nóbrega da Silva, Leonardo Ferreira Soares, Marilia de Arruda Cardoso Smith, Edilson Carvalho Sousa, Rommel Mario Rodríguez Burbano, Arnaldo Correia de Medeiros, Eleonidas Moura Lima.
Abstract
Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. The results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher's exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (χ(2) = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.Entities:
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Year: 2014 PMID： 24453034 DOI： 10.1007/s13277-014-1656-z
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283