Literature DB >> 18061666

Lack of association of NQO1 and GSTP1 polymorphisms with multiple myeloma risk.

Valentina Maggini1, Gabriele Buda, Sara Galimberti, Alessandro Martino, Enrico Orciuolo, Fortunato Morabito, Roberto Bono, Roberto Barale, Mario Petrini, Anna Maria Rossi.   

Abstract

Individual differences in xenobiotica metabolising capacity can influence susceptibility to multiple myeloma. NQO1 and GSTT1 polymorphisms were recently reported as risk factors for multiple myeloma and GSTP1 genotype was found to be a prognostic marker for therapy outcome in multiple myeloma. The aim of this study was to determine whether specific defective alleles of NQO1 (P187S) and GSTP1 (I105V) genes are associated with increased risk of multiple myeloma. Individual genotypes of 128 patients affected by multiple myeloma and 245 healthy controls were determined and our results do not support any major role of NQO1 or GSTP1 polymorphisms in multiple myeloma pathogenesis.

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Year:  2007        PMID： 18061666     DOI： 10.1016/j.leukres.2007.10.008

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  5 in total

1.  Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil.

Authors:  Rubistenia Miranda Soares de Araújo; Cynthia Farias Vieira de Melo; Fidelis Manes Neto; Juarez Nóbrega da Silva; Leonardo Ferreira Soares; Marilia de Arruda Cardoso Smith; Edilson Carvalho Sousa; Rommel Mario Rodríguez Burbano; Arnaldo Correia de Medeiros; Eleonidas Moura Lima
Journal:  Tumour Biol       Date:  2014-01-23

Review 2.  The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer.

Authors:  Kenneth D Tew; Yefim Manevich; Christina Grek; Ying Xiong; Joachim Uys; Danyelle M Townsend
Journal:  Free Radic Biol Med       Date:  2011-04-22       Impact factor: 7.376

3.  Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India.

Authors:  Soumee Ghosh; Sudakshina Ghosh; Biswabandhu Bankura; Makhan Lal Saha; Suvendu Maji; Souvik Ghatak; Arup Kumar Pattanayak; Susanta Sadhukhan; Manalee Guha; Senthil Kumar Nachimuthu; Chinmay Kumar Panda; Biswanath Maity; Madhusudan Das
Journal:  Tumour Biol       Date:  2016-01-14

4.  Inherited polymorphisms in hyaluronan synthase 1 predict risk of systemic B-cell malignancies but not of breast cancer.

Authors:  Hemalatha Kuppusamy; Helga M Ogmundsdottir; Eva Baigorri; Amanda Warkentin; Hlif Steingrimsdottir; Vilhelmina Haraldsdottir; Michael J Mant; John Mackey; James B Johnston; Sophia Adamia; Andrew R Belch; Linda M Pilarski
Journal:  PLoS One       Date:  2014-06-20       Impact factor: 3.240

5.  The NQO1 polymorphism C609T (Pro187Ser) and cancer susceptibility: a comprehensive meta-analysis.

Authors:  B Lajin; A Alachkar
Journal:  Br J Cancer       Date:  2013-07-16       Impact factor: 7.640
  5 in total

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