Literature DB >> 2084706

Genetic heterogeneity of the human glutathione transferases: a complex of gene families.

P Board1, M Coggan, P Johnston, V Ross, T Suzuki, G Webb.   

Abstract

The glutathione transferases (GSTs) are involved in the metabolism of a wide range of compounds of both exogenous and endogenous origin. There is evidence that deficiency of GST may increase sensitivity to certain environmentally derived carcinogens. In contrast, elevated expression has been implicated in resistance to therapeutic drugs. The GSTs are the products of several gene families. This review summarizes the present knowledge of the genetic interrelationships between the various isoenzymes, their deficiencies and the physical locations of their genes.

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Year:  1990        PMID： 2084706     DOI： 10.1016/0163-7258(90)90054-6

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  52 in total

1.  A study of glutathione S-transferase pi expression in central nervous system of subjects with amyotrophic lateral sclerosis using RNA extraction from formalin-fixed, paraffin-embedded material.

Authors:  Ewa Usarek; Beata Gajewska; Beata Kaźmierczak; Magdalena Kuźma; Dorota Dziewulska; Anna Barańczyk-Kuźma
Journal:  Neurochem Res       Date:  2005-08       Impact factor: 3.996

2.  GST M1 polymorphism associates with DNA oxidative damage and mortality among hemodialysis patients.

Authors:  Yi-Sheng Lin; Szu-Chun Hung; Yau-Huei Wei; Der-Cherng Tarng
Journal:  J Am Soc Nephrol       Date:  2008-12-03       Impact factor: 10.121

3.  GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia.

Authors:  Martin Stanulla; Elke Schäffeler; Stefan Arens; Anke Rathmann; André Schrauder; Karl Welte; Michel Eichelbaum; Ulrich M Zanger; Martin Schrappe; Matthias Schwab
Journal:  Int J Hematol       Date:  2005-01       Impact factor: 2.490

4.  Gene-environment interactions associated with CYP1A1 MspI and GST polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population.

Authors:  Soya Sisy Sam; Vinod Thomas; K S Reddy; Gopalakrishnan Surianarayanan; Adithan Chandrasekaran
Journal:  J Cancer Res Clin Oncol       Date:  2009-12-10       Impact factor: 4.553

5.  Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil.

Authors:  Rubistenia Miranda Soares de Araújo; Cynthia Farias Vieira de Melo; Fidelis Manes Neto; Juarez Nóbrega da Silva; Leonardo Ferreira Soares; Marilia de Arruda Cardoso Smith; Edilson Carvalho Sousa; Rommel Mario Rodríguez Burbano; Arnaldo Correia de Medeiros; Eleonidas Moura Lima
Journal:  Tumour Biol       Date:  2014-01-23

Review 6.  When less is more: gene loss as an engine of evolutionary change.

Authors:  M V Olson
Journal:  Am J Hum Genet       Date:  1999-01       Impact factor: 11.025

7.  Expression of xenobiotic metabolizing enzymes in tumours of the urinary bladder.

Authors:  G I Murray; V E Taylor; J A McKay; R J Weaver; S W Ewen; W T Melvin; M D Burke
Journal:  Int J Exp Pathol       Date:  1995-08       Impact factor: 1.925

8.  GSTM1 null polymorphism at the glutathione S-transferase M1 locus: phenotype and genotype studies in patients with primary biliary cirrhosis.

Authors:  M H Davies; E Elias; S Acharya; W Cotton; G C Faulder; A A Fryer; R C Strange
Journal:  Gut       Date:  1993-04       Impact factor: 23.059

9.  Xenobiotic metabolising enzyme expression in colonic neoplasia.

Authors:  J A McKay; G I Murray; R J Weaver; S W Ewen; W T Melvin; M D Burke
Journal:  Gut       Date:  1993-09       Impact factor: 23.059

10.  Cytochrome P450 expression in oesophageal cancer.

Authors:  G I Murray; D Shaw; R J Weaver; J A McKay; S W Ewen; W T Melvin; M D Burke
Journal:  Gut       Date:  1994-05       Impact factor: 23.059
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