Jimi Kim1, Hyejin Kim1, Jeonghee Lee1, Il Ju Choi2, Young-Il Kim2, Jeongseon Kim1. 1. Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, South Korea. 2. Center for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, South Korea.
Abstract
BACKGROUND: Chronic gastritis along with Helicobacter pylori (H. pylori) infection has been implicated in inflammatory response-related genes linked to the causation of gastric cancer. Glutathione S-transferase Pi (GSTP1) plays a role in regulating oxidative stress and detoxification against carcinogenesis. In this study, we aimed to determine whether an antioxidant-rich diet is associated with gastric cancer risk and identify how this association could be altered by GSTP1 genetic variants. METHODS: This study included 1,245 participants (415 cases and 830 controls) matched for age and sex. The dietary antioxidant capacity was estimated based on the oxygen radical absorbance capacity (ORAC) incorporated with a semiquantitative food frequency questionnaire. Five single nucleotide polymorphisms (SNPs) of GSTP1 (rs1695, rs749174, rs1871042, rs4891, and rs947895) were selected among the exome array genotype data. RESULTS: High dietary ORAC was inversely associated with gastric cancer (hydrophilic ORAC OR T3 vs . T1, 95% CI = 0.57, 0.39-0.82, P = 0.004; lipophilic ORAC = 0.66, 0.45-0.95, P = 0.021; total phenolics = 0.57, 0.39-0.83, P = 0.005). The polymorphism rs1871042 increased the risk of gastric cancer (OR, 95% CI = 1.55, 1.10-2.16, P = 0.01, CT+TT vs. CC). A remarkably reduced risk of gastric cancer was observed among those who had a high dietary ORAC according to rs1871042 polymorphism (hydrophilic ORAC OR T3 vs . T1, 95% CI = 0.36, 0.17-0.78, P for trend = 0.013; lipophilic ORAC = 0.58, 0.37-0.93, P for trend = 0.021; total phenolics = 0.38, 0.17-0.83, P for trend = 0.019). CONCLUSIONS: Our findings indicate that dietary ORAC intake may be inversely associated with the risk of gastric cancer altered by genetic variants of GSTP1, providing new intervention strategies for gastric cancer patients.
BACKGROUND: Chronic gastritis along with Helicobacter pylori (H. pylori) infection has been implicated in inflammatory response-related genes linked to the causation of gastric cancer. Glutathione S-transferase Pi (GSTP1) plays a role in regulating oxidative stress and detoxification against carcinogenesis. In this study, we aimed to determine whether an antioxidant-rich diet is associated with gastric cancer risk and identify how this association could be altered by GSTP1 genetic variants. METHODS: This study included 1,245 participants (415 cases and 830 controls) matched for age and sex. The dietary antioxidant capacity was estimated based on the oxygen radical absorbance capacity (ORAC) incorporated with a semiquantitative food frequency questionnaire. Five single nucleotide polymorphisms (SNPs) of GSTP1 (rs1695, rs749174, rs1871042, rs4891, and rs947895) were selected among the exome array genotype data. RESULTS: High dietary ORAC was inversely associated with gastric cancer (hydrophilic ORAC OR T3 vs . T1, 95% CI = 0.57, 0.39-0.82, P = 0.004; lipophilic ORAC = 0.66, 0.45-0.95, P = 0.021; total phenolics = 0.57, 0.39-0.83, P = 0.005). The polymorphism rs1871042 increased the risk of gastric cancer (OR, 95% CI = 1.55, 1.10-2.16, P = 0.01, CT+TT vs. CC). A remarkably reduced risk of gastric cancer was observed among those who had a high dietary ORAC according to rs1871042 polymorphism (hydrophilic ORAC OR T3 vs . T1, 95% CI = 0.36, 0.17-0.78, P for trend = 0.013; lipophilic ORAC = 0.58, 0.37-0.93, P for trend = 0.021; total phenolics = 0.38, 0.17-0.83, P for trend = 0.019). CONCLUSIONS: Our findings indicate that dietary ORAC intake may be inversely associated with the risk of gastric cancer altered by genetic variants of GSTP1, providing new intervention strategies for gastric cancer patients.
Authors: Carlos A Gonzalez; Leila Lujan-Barroso; H B Bueno-de-Mesquita; Mazda Jenab; Eric J Duell; Antonio Agudo; Anne Tjønneland; Marie Christine Boutron-Ruault; Françoise Clavel-Chapelon; Marina Touillaud; Birgit Teucher; Rudolf Kaaks; Heiner Boeing; Annika Steffen; Antonia Trichopoulou; Dimitrios Roukos; Tina Karapetyan; Domenico Palli; Giovanna Tagliabue; Amalia Mattiello; Rosario Tumino; Fulvio Ricceri; Peter D Siersema; Mattijs E Numans; Petra P H Peeters; Christine L Parr; Guri Skeie; Eiliv Lund; J Ramón Quirós; Emilio Sánchez-Cantalejo; Carmen Navarro; Aurelio Barricarte; Miren Dorronsoro; Roy Ehrnström; Sara Regner; Kay-Tee Khaw; Nick Wareham; Timothy J Key; Francesca L Crowe; Hendrik Blaker; Isabelle Romieu; Elio Riboli Journal: Int J Cancer Date: 2012-04-26 Impact factor: 7.396
Authors: A Romero; M Martín; B Oliva; J de la Torre; V Furio; M de la Hoya; J A García-Sáenz; A Moreno; J M Román; E Diaz-Rubio; T Caldés Journal: Ann Oncol Date: 2011-11-02 Impact factor: 32.976