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Literature DB >> 2441560

A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration.

D W Dickson, H Ksiezak-Reding, P Davies, S H Yen.

Abstract

A monoclonal antibody, raised against extracts from Alzheimer brain, that recognizes a phosphorylated epitope in high molecular weight neurofilament proteins and tau proteins also immunostains Alzheimer neurofibrillary tangles, neurites in senile plaques and granulovacuolar degeneration. This result suggest that granulovacuolar degeneration may contain phosphorylated proteins, possibly due to autophagy of phosphorylated perikaryal proteins that appear to be increased in Alzheimer's disease.

Entities: Disease Gene

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Substances：

Year: 1987 PMID： 2441560 DOI： 10.1007/bf00686619

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

19 in total

1. Two monoclonal antibodies recognize Alzheimer's neurofibrillary tangles, neurofilament, and microtubule-associated proteins.

Authors: H Ksiezak-Reding; S H Yen
Journal: J Neurochem Date: 1987-02 Impact factor: 5.372

2. Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.

Authors: M C Haugh; A Probst; J Ulrich; J Kahn; B H Anderton
Journal: J Neurol Neurosurg Psychiatry Date: 1986-11 Impact factor: 10.154

3. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

Authors: I Grundke-Iqbal; K Iqbal; Y C Tung; M Quinlan; H M Wisniewski; L I Binder
Journal: Proc Natl Acad Sci U S A Date: 1986-07 Impact factor: 11.205

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Authors: M L Shelanski; F Gaskin; C R Cantor
Journal: Proc Natl Acad Sci U S A Date: 1973-03 Impact factor: 11.205

5. The fine structure of some intraganglionic alterations. Neurofibrillary tangles, granulovacuolar bodies and "rod-like" structures as seen in Guam amyotrophic lateral sclerosis and parkinsonism-dementia complex.

Authors: A Hirano; H M Dembitzer; L T Kurland; H M Zimmerman
Journal: J Neuropathol Exp Neurol Date: 1968-04 Impact factor: 3.685

6. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

7. Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants.

Authors: B H Anderton; D Breinburg; M J Downes; P J Green; B E Tomlinson; J Ulrich; J N Wood; J Kahn
Journal: Nature Date: 1982-07-01 Impact factor: 49.962

8. Immunohistological study of granulovacuolar degeneration using monoclonal antibodies to neurofilaments.

Authors: J Kahn; B H Anderton; A Probst; J Ulrich; M M Esiri
Journal: J Neurol Neurosurg Psychiatry Date: 1985-09 Impact factor: 10.154

9. Monoclonal antibodies to Alzheimer neurofibrillary tangles. 1. Identification of polypeptides.

Authors: S H Yen; A Crowe; D W Dickson
Journal: Am J Pathol Date: 1985-08 Impact factor: 4.307

10. Ballooned neurons in select neurodegenerative diseases contain phosphorylated neurofilament epitopes.

Authors: D W Dickson; S H Yen; K I Suzuki; P Davies; J H Garcia; A Hirano
Journal: Acta Neuropathol Date: 1986 Impact factor: 17.088

29 in total

1. Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments.

Authors: M E King; N Ghoshal; J S Wall; L I Binder; H Ksiezak-Reding
Journal: Am J Pathol Date: 2001-04 Impact factor: 4.307

2. Immunocytochemistry of neurofibrillary tangles with antibodies to subregions of tau protein: identification of hidden and cleaved tau epitopes and a new phosphorylation site.

Authors: D W Dickson; H Ksiezak-Reding; W K Liu; P Davies; A Crowe; S H Yen
Journal: Acta Neuropathol Date: 1992 Impact factor: 17.088

3. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover.

Authors: Xiongwei Zhu; Rudy J Castellani; Paula I Moreira; Gjumrakch Aliev; Justin C Shenk; Sandra L Siedlak; Peggy L R Harris; Hisashi Fujioka; Lawrence M Sayre; Pamela A Szweda; Luke I Szweda; Mark A Smith; George Perry
Journal: Free Radic Biol Med Date: 2011-11-12 Impact factor: 7.376

4. Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death.

Authors: C Stadelmann; T L Deckwerth; A Srinivasan; C Bancher; W Brück; K Jellinger; H Lassmann
Journal: Am J Pathol Date: 1999-11 Impact factor: 4.307

5. Meningioangiomatosis: an immunocytochemical study.

Authors: J J Goates; D W Dickson; D S Horoupian
Journal: Acta Neuropathol Date: 1991 Impact factor: 17.088

6. The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.

Authors: Jerzy Wegiel; Karol Dowjat; Wojciech Kaczmarski; Izabela Kuchna; Krzysztof Nowicki; Janusz Frackowiak; Bozena Mazur Kolecka; Jarek Wegiel; Wayne P Silverman; Barry Reisberg; Mony Deleon; Thomas Wisniewski; Cheng-Xin Gong; Fei Liu; Tatyana Adayev; Mo-Chou Chen-Hwang; Yu-Wen Hwang
Journal: Acta Neuropathol Date: 2008-08-12 Impact factor: 17.088

7. Phosphorylated tau immunoreactivity of granulovacuolar bodies (GVB) of Alzheimer's disease: localization of two amino terminal tau epitopes in GVB.

Authors: D W Dickson; W K Liu; Y Kress; J Ku; O DeJesus; S H Yen
Journal: Acta Neuropathol Date: 1993 Impact factor: 17.088