Literature DB >> 2432188

Alzheimer neurofibrillary tangles contain phosphorylated and hidden neurofilament epitopes.

M C Haugh, A Probst, J Ulrich, J Kahn, B H Anderton.   

Abstract

Three monoclonal antibodies to neurofilaments (RT97, BF10 and 147), two of which also recognised neurofibrillary tangles (RT97 and BF10), have all been shown to be specific for phosphorylated epitopes. Treatment of histological sections with alkaline phosphatase prior to immunostaining resulted in reduction of axonal neurofilament staining with all three whilst the neurofibrillary tangles staining with BF10 was unaffected. Antibody 147 was found to recognise weakly some neurofibrillary tangles following alkaline phosphatase treatment. The results presented confirm the presence of structurally abnormal but phosphorylated neurofilaments in neurofibrillary tangles.

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Year:  1986        PMID： 2432188      PMCID： PMC1029067          DOI： 10.1136/jnnp.49.11.1213

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  29 in total

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Authors:  H M Wiśniewski; H K Narang; R D Terry
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Journal:  Brain Res       Date:  1984-11-19       Impact factor: 3.252

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Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

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Journal:  Lancet       Date:  1979-03-17       Impact factor: 79.321

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Journal:  J Cell Biol       Date:  1985-06       Impact factor: 10.539
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  25 in total

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Authors:  M A Wrzolek; P A Merz; R Kascsak; I Grundke-Iqbal; K Iqbal; R Rubenstein; M Tonna-DeMasi; N L Goller; P Mehta; H M Wisniewski
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

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Authors:  G E Dale; A Probst; P Luthert; J Martin; B H Anderton; P N Leigh
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3.  Age-related accumulation of amyloid inclusions in adrenal cortical cells.

Authors:  L Eriksson; P Westermark
Journal:  Am J Pathol       Date:  1990-02       Impact factor: 4.307

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Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

5.  The neurofilament antibody RT97 recognises a developmentally regulated phosphorylation epitope on microtubule-associated protein 1B.

Authors:  M Johnstone; R G Goold; I Fischer; P R Gordon-Weeks
Journal:  J Anat       Date:  1997-08       Impact factor: 2.610

6.  Neurofibrillary tangles in Alzheimer's disease and progressive supranuclear palsy: antigenic similarities and differences. Microtubule-associated protein tau antigenicity is prominent in all types of tangles.

Authors:  C Bancher; H Lassmann; H Budka; I Grundke-Iqbal; K Iqbal; G Wiche; F Seitelberger; H M Wisniewski
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

7.  A monoclonal antibody that recognizes a phosphorylated epitope in Alzheimer neurofibrillary tangles, neurofilaments and tau proteins immunostains granulovacuolar degeneration.

Authors:  D W Dickson; H Ksiezak-Reding; P Davies; S H Yen
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

8.  Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes.

Authors:  J Ulrich; M Haugh; B H Anderton; A Probst; C Lautenschlager; B His
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

9.  Progressive medullary failure associated with neurofibrillary degeneration.

Authors:  H G Lidov; L W Duchen; P K Thomas; D C Thrush
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-05       Impact factor: 10.154

10.  New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies.

Authors:  P N Leigh; A Probst; G E Dale; D P Power; J P Brion; A Dodson; B H Anderton
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088
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